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- W2046617191 abstract "Metabolomic associates a quantitative analysis method of metabolites contained in biological samples to a multivariate statistical analysis and allows either to establish metabolic profiles as in pathology (obesity, muscular dystrophy, diabete), or to identify biological markers. PURPOSE: The objective of this study is the exploration by 1H NMR spectroscopy of mice metabolome of mice having performed an exhaustive exercise either at the critical velocity (Vc) which delineate the solicitation of the aerobic metabolism or the peak velocity (vPeak). MATERIALS AND METHODS: Mice were divided into 3 groups: 10 control mice, 7 Vc mice exercising at Vc and 13 Vpeak mice exercising at Vpeak, 2h before sacrifice. Blood was drawn at the eye corner, deproteinized with of trichloroacetic acid. The urine was collected, either in the cage before sacrifice, either directly in the bladder after sacrifice. The 1D proton spectra of blood or urine samples were obtained using a Varian spectrometer at 500 MHz. The spectra were divided into 0.01ppm buckets. Their intensities were analyzed by partial least square analysis (PLS) using the Simca-P + software. RESULTS: Using blood and urine samples, the three groups could be discriminated with a PLS analysis with a clear cut off between control mice and Vc or Vpeak mice. Among the most discriminating metabolites in blood, glucose, dimethylamine are characterizing the control mice. In urine, lactate allantoin and trans-aconitate citrate hippurate and carnitine were the most discriminating metabolites. At Vpeak (37 ± 30min) and Vc (60 ± 31 min) mice use of aerobic glycolysis first and proteolysis is necessary to a prolonged exercise over an hour duration CONCLUSION: metabolomic combined with exercise allows revealing the alteration of metabolism more sensitive than in non exercise mice." @default.
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- W2046617191 date "2010-05-01" @default.
- W2046617191 modified "2023-10-14" @default.
- W2046617191 title "Metabolomic By Nmr Spectroscopy For Investigation Of Metabolism After Physical Exercise In A Mouse Model" @default.
- W2046617191 doi "https://doi.org/10.1249/01.mss.0000386537.43953.84" @default.
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