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- W2046617660 abstract "Cadmium (Cd) is one of the environmental pollutants that affect various tissues and organs including testis. Harmful effect of cadmium on testis is known to be germ cell degeneration and impairment of testicular steroidogenesis. In the present study, the effect of diallyl sulfide (DAS), a sulfur-containing volatile compound present in garlic, and zinc (Zn) was investigated on cadmium-induced testicular toxicity in rats. Male adult Wistar rats treated with cadmium (2.5 mg/kg body wt, five times a week for 4 weeks) showed decreased body weight, paired testicular weight, relative testicular weight, serum testosterone, luteinizing hormone, follicle-stimulating hormone, and testicular total antioxidant capacity (TAC) and protein levels. Testicular steroidogenic enzymes, such as 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-hydroxysteroid dehydrogenase (17β-HSD), and marker enzymes, such as sorbitol dehydrogenase (SDH), lactate dehydrogenase (LDH), acid phosphatase (ACP), alkaline phosphatase (ALP), and glucose-6-phosphate dehydrogenase (G6PD), showed a significant decrease in activities whereas that of γ-glutamyl transferase was significantly increased after cadmium exposure. The results have revealed that concurrent treatment with DAS or zinc restored key steroidogenic enzymes, SDH, LDH, and G6PD and increased testicular weight significantly. DAS restored the TAC level and increased testosterone level and relative testicular weight significantly. Zinc restored testicular protein level and body weight. It can be concluded that cadmium causes testicular toxicity and inhibits androgen production in adult male rats probably by affecting pituitary gonadotrophins and that concurrent administration of DAS or zinc provides protection against cadmium-induced testicular toxicity. © 2008 Wiley Periodicals, Inc. J Biochem Mol Toxicol 22:345–353, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20247" @default.
- W2046617660 created "2016-06-24" @default.
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- W2046617660 date "2008-09-01" @default.
- W2046617660 modified "2023-09-27" @default.
- W2046617660 title "Effects of diallyl sulfide and zinc on testicular steroidogenesis in cadmium-treated male rats" @default.
- W2046617660 cites W1182003361 @default.
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- W2046617660 cites W1775749144 @default.
- W2046617660 cites W1923689774 @default.
- W2046617660 cites W1963787678 @default.
- W2046617660 cites W1975280296 @default.
- W2046617660 cites W1979733152 @default.
- W2046617660 cites W1982044211 @default.
- W2046617660 cites W1983045184 @default.
- W2046617660 cites W1984617585 @default.
- W2046617660 cites W1985690685 @default.
- W2046617660 cites W1986357882 @default.
- W2046617660 cites W1986752439 @default.
- W2046617660 cites W1987018263 @default.
- W2046617660 cites W1987987034 @default.
- W2046617660 cites W1995266939 @default.
- W2046617660 cites W1995649386 @default.
- W2046617660 cites W1995751234 @default.
- W2046617660 cites W1997768813 @default.
- W2046617660 cites W2003051737 @default.
- W2046617660 cites W2007975766 @default.
- W2046617660 cites W2010348287 @default.
- W2046617660 cites W2014310881 @default.
- W2046617660 cites W2017311339 @default.
- W2046617660 cites W2020418108 @default.
- W2046617660 cites W2035009390 @default.
- W2046617660 cites W2039670554 @default.
- W2046617660 cites W2041349273 @default.
- W2046617660 cites W2041750631 @default.
- W2046617660 cites W2047957142 @default.
- W2046617660 cites W2050378713 @default.
- W2046617660 cites W2051319109 @default.
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- W2046617660 cites W2075635449 @default.
- W2046617660 cites W2081568627 @default.
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- W2046617660 doi "https://doi.org/10.1002/jbt.20247" @default.
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