FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046643048> ?p ?o ?g. }

• W2046643048 endingPage "518" @default.
• W2046643048 startingPage "511" @default.
• W2046643048 abstract "Alzheimer's disease (AD) and several other neurological disorders have been linked to the overactivation of glutamatergic transmission and excitotoxicity as a common pathway of neuronal injury. The beta-amyloid peptide (Abeta) is centrally related to the pathogenesis of AD, and previous reports have demonstrated that the blockade of glutamate receptors prevents Abeta-induced neuronal death. We show that taurine, a beta-amino acid found at high concentrations in the brain, protects chick retinal neurons in culture against the neurotoxicity of Abeta and glutamate receptor agonists. The protective effect of taurine is not mediated by interaction with glutamate receptors, as demonstrated by binding studies using radiolabeled glutamate receptor ligands. The neuroprotective action of taurine is blocked by picrotoxin, an antagonist of GABA(A) receptors. GABA and the GABA(A) receptor agonists phenobarbital and melatonin also protect neurons against Abeta-induced neurotoxicity. These results suggest that activation of GABA receptors decreases neuronal vulnerability to excitotoxic damage and that pharmacological manipulation of the excitatory and inhibitory neurotransmitter tonus may protect neurons against a variety of insults. GABAergic transmission may represent a promising target for the treatment of AD and other neurological disorders in which excitotoxicity plays a relevant role." @default.
• W2046643048 created "2016-06-24" @default.
• W2046643048 creator A5033602118 @default.
• W2046643048 creator A5048153996 @default.
• W2046643048 creator A5069440026 @default.
• W2046643048 creator A5070851422 @default.
• W2046643048 creator A5071662320 @default.
• W2046643048 creator A5087245774 @default.
• W2046643048 date "2004-03-01" @default.
• W2046643048 modified "2023-10-04" @default.
• W2046643048 title "Taurine prevents the neurotoxicity of β‐amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders" @default.
• W2046643048 cites W1532004838 @default.
• W2046643048 cites W1586784857 @default.
• W2046643048 cites W1654554888 @default.
• W2046643048 cites W1680162993 @default.
• W2046643048 cites W1897469256 @default.
• W2046643048 cites W1968236166 @default.
• W2046643048 cites W1972265008 @default.
• W2046643048 cites W1976784386 @default.
• W2046643048 cites W1978030967 @default.
• W2046643048 cites W1981226125 @default.
• W2046643048 cites W1988340492 @default.
• W2046643048 cites W1988367141 @default.
• W2046643048 cites W1989578603 @default.
• W2046643048 cites W1991284582 @default.
• W2046643048 cites W1991379393 @default.
• W2046643048 cites W2000243807 @default.
• W2046643048 cites W2003785254 @default.
• W2046643048 cites W2003894983 @default.
• W2046643048 cites W2004828074 @default.
• W2046643048 cites W2013705874 @default.
• W2046643048 cites W2016981332 @default.
• W2046643048 cites W2018241752 @default.
• W2046643048 cites W2019263514 @default.
• W2046643048 cites W2022516842 @default.
• W2046643048 cites W2022785521 @default.
• W2046643048 cites W2023531011 @default.
• W2046643048 cites W2025014038 @default.
• W2046643048 cites W2036042937 @default.
• W2046643048 cites W2039282223 @default.
• W2046643048 cites W2042563090 @default.
• W2046643048 cites W2048132881 @default.
• W2046643048 cites W2050279035 @default.
• W2046643048 cites W2052327095 @default.
• W2046643048 cites W2056015172 @default.
• W2046643048 cites W2056328685 @default.
• W2046643048 cites W2056505363 @default.
• W2046643048 cites W2058245542 @default.
• W2046643048 cites W2069638185 @default.
• W2046643048 cites W2081294540 @default.
• W2046643048 cites W2086233259 @default.
• W2046643048 cites W2094411486 @default.
• W2046643048 cites W2109171315 @default.
• W2046643048 cites W2115978010 @default.
• W2046643048 cites W2116837408 @default.
• W2046643048 cites W2128304152 @default.
• W2046643048 cites W2135573968 @default.
• W2046643048 cites W2137358718 @default.
• W2046643048 cites W2138224217 @default.
• W2046643048 cites W2148999943 @default.
• W2046643048 cites W2286080646 @default.
• W2046643048 cites W2316145923 @default.
• W2046643048 cites W2413356897 @default.
• W2046643048 cites W4293247451 @default.
• W2046643048 doi "https://doi.org/10.1096/fj.03-0739com" @default.
• W2046643048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15003996" @default.
• W2046643048 hasPublicationYear "2004" @default.
• W2046643048 type Work @default.
• W2046643048 sameAs 2046643048 @default.
• W2046643048 citedByCount "211" @default.
• W2046643048 countsByYear W20466430482012 @default.
• W2046643048 countsByYear W20466430482013 @default.
• W2046643048 countsByYear W20466430482014 @default.
• W2046643048 countsByYear W20466430482015 @default.
• W2046643048 countsByYear W20466430482016 @default.
• W2046643048 countsByYear W20466430482017 @default.
• W2046643048 countsByYear W20466430482018 @default.
• W2046643048 countsByYear W20466430482019 @default.
• W2046643048 countsByYear W20466430482020 @default.
• W2046643048 countsByYear W20466430482021 @default.
• W2046643048 countsByYear W20466430482022 @default.
• W2046643048 countsByYear W20466430482023 @default.
• W2046643048 crossrefType "journal-article" @default.
• W2046643048 hasAuthorship W2046643048A5033602118 @default.
• W2046643048 hasAuthorship W2046643048A5048153996 @default.
• W2046643048 hasAuthorship W2046643048A5069440026 @default.
• W2046643048 hasAuthorship W2046643048A5070851422 @default.
• W2046643048 hasAuthorship W2046643048A5071662320 @default.
• W2046643048 hasAuthorship W2046643048A5087245774 @default.
• W2046643048 hasConcept C126322002 @default.
• W2046643048 hasConcept C169760540 @default.
• W2046643048 hasConcept C170493617 @default.
• W2046643048 hasConcept C17077164 @default.
• W2046643048 hasConcept C185592680 @default.
• W2046643048 hasConcept C25498285 @default.
• W2046643048 hasConcept C2776108384 @default.
• W2046643048 hasConcept C2779177108 @default.
• W2046643048 hasConcept C2779491297 @default.

• next