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- W2046647573 abstract "The response to centrally administered β-endorphin has been characterized by decreasing sympathetic nervous activity and decreased cardiovascular tone. We investigated the effect of the central administration of both mu and kappa opioid receptor agonist and antagonists on cardiovascular responses. The administration of the mu agonist, DAMGO (0.2 nmol) increased the mean arterial pressure (MAP) and stimulated iliac vasoconstriction while higher doses (2 and 20 nmol) decreased MAP and stimulated iliac vasodilation. The administration of the kappa receptor agonist, Dynorphin decreased the MAP and stimulated superior mesenteric vasodilation. β-Funaltrexamine reduced MAP and superior mesenteric vasodilation while nor-binaltorphimine increased MAP and iliac and superior mesenteric vasoconstriction. We conclude that mu receptor activation decrease or increase MAP depending on the mu agonist concentration. However, kappa receptor activation is consistently associated with a decrease in MAP." @default.
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- W2046647573 date "2003-05-01" @default.
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- W2046647573 title "Cardiovascular responses to central administration of mu and kappa opioid receptor agonist and antagonist in normal rats" @default.
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- W2046647573 doi "https://doi.org/10.1016/s0196-9781(03)00122-0" @default.
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