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• W2046647681 abstract "The present study evaluated the expression of key molecules and the status of DNA in both oral squamous cell carcinoma (OSCC) and adjacent tissues to establish a molecular surgical boundary and provide a cancer progression model. Biopsy samples from 50 OSCC patients were divided into T (cancer), P1 (0–0.5 cm), P2 (0.5–1 cm), P3 (1–1.5 cm) and P4 (1.5–2 cm) groups based on the distances from the visible boundary of the primary focus. Twenty samples of normal mucosa were used as controls. We used immunohistochemical staining and flow cytometry to evaluate p53, p21 CIP1/WAF1 , eIF4E and Ki-67 expression and to determine DNA status, respectively. Sub-mucosal invasion was present in the P1 and P2 groups as determined by haematoxylin and eosin staining. Mutant p53 expression decreased gradually from cancerous to normal mucosae, whereas p21 CIP1/WAF1 expression displayed an opposite trend. eIF4E expression decreased from cancerous to normal mucosae. Ki-67 expression, the heteroploidy ratio, S-phase fraction and proliferative index decreased gradually with the distance from the tumour centre. Based on these results, we suggest that the resection boundary in OSCC surgery should be beyond 2 cm from the tumour. Additionally, the adjacent tissues of the primary focus could be used as a model for assessing cancer progression. Surgical removal of apparently normal tissue adjacent to oral squamous cell carcinoma (OSCC) tumors could improve patient outcomes. OSCC is the most common oral cancer and survival rates are only around 50%, mainly due to local recurrence. Long-Jiang Li, at Sichuan University, Chengdu, China, and colleagues, examined 50 biopsy samples from patients treated for OSCC and found that tissues up to 2 cm away from the visible border of the tumor could be pre-cancerous. A gradual decrease in the expression of cancer-related molecules from the tumor to surrounding tissue suggests that some cells, despite their normal appearance, have begun to transform into tumor-forming cells. By determining the molecular boundary of OSCC tumors, these findings help to establish a safer surgical margin which fully removes precancerous tissue and thus lowers the risk of recurrence." @default.
• W2046647681 created "2016-06-24" @default.
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• W2046647681 date "2015-04-03" @default.
• W2046647681 modified "2023-10-18" @default.
• W2046647681 title "Expression of p53, p21 CIP1/WAF1 and eIF4E in the adjacent tissues of oral squamous cell carcinoma: establishing the molecular boundary and a cancer progression model" @default.
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• W2046647681 doi "https://doi.org/10.1038/ijos.2015.5" @default.
• W2046647681 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4582560" @default.
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