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• W2046647913 abstract "SUMMARY Even with hormone- and HER2-targeted anticancer agents, intrinsic and acquired resistance is a common occurrence in estrogen receptor-positive and HER2-positive breast cancers, respectively. As for triple-negative breast cancer, its relative uncommonness, aggressiveness and impressive heterogeneity have been only a few of the challenges researchers and clinicians face in making strides against this disease. This article reviews the involvement of the PI3K pathway in these resistance mechanisms. It also summarizes preclinical and clinical data suggesting the potential of combination therapy with PI3K inhibitors in preventing resistance and restoring sensitivity to hormone-targeted, HER2-targeted agents and chemotherapy." @default.
• W2046647913 created "2016-06-24" @default.
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• W2046647913 date "2014-07-01" @default.
• W2046647913 modified "2023-09-27" @default.
• W2046647913 title "What is the potential of using PI3K inhibitors in the management of breast cancer in the clinic?" @default.
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• W2046647913 doi "https://doi.org/10.2217/bmt.14.26" @default.
• W2046647913 hasPublicationYear "2014" @default.
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