FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046657684> ?p ?o ?g. }

• W2046657684 endingPage "381" @default.
• W2046657684 startingPage "375" @default.
• W2046657684 abstract "The stability of a number of enzymes which have a very short half-life as assessed by measurements in vivo, namely ornithine decarboxylase, serine dehydratase, tyrosine aminotransferase and 5-aminolevulinate synthase, and the stability of enzymes with a moderate half-life i.e. glutamate dehydrogenase, alanine aminotransferase and lactate dehydrogenase, were studied in whole liver and in tissue fractions thereof. While in general the measurements in vitro are in agreement with the data obtained in vivo, indicating the power of the simple technique herein described, there was enough variation in stability to indicate that in addition to their intrinsic basic stability due to the particular genetically determined structure of the protein, environmental factors must play an important role in the half-life of these enzymes. For example, tyrosine aminotransferase and particularly serine dehydratase are less stable in the tissue than in the homogenate and supernatant fractions and consequently are less stable in vitro than in vivo. Lactate dehydrogenase and alanine amino-transferase are stable for as long as 18 h in the homogenate and supernatant; however alanine aminotransferase activity in tissues decreases after 6 h incubation. The half-life of inactivation in the homogenate for glutamate dehydrogenase is 3–4 h. Interestingly, the activity in the tissue increases up to 6 h, while with longer periods of incubation the bulk of the enzyme leaked out into the medium and remained constant for 24 h. Experiments with “washed-residue” fractions show that the enzyme is inactivated by cytosol components. No clear difference between inactivation in vitro before and after starvation, following a high-protein diet or after injection of inhibitors was found for any of the enzymes studied." @default.
• W2046657684 created "2016-06-24" @default.
• W2046657684 creator A5011456955 @default.
• W2046657684 creator A5040234310 @default.
• W2046657684 creator A5081151384 @default.
• W2046657684 date "1974-05-01" @default.
• W2046657684 modified "2023-10-14" @default.
• W2046657684 title "Comparative Studies in vivo and in vitro of Rat-Liver Enzymes" @default.
• W2046657684 cites W1427746131 @default.
• W2046657684 cites W1549293240 @default.
• W2046657684 cites W1564577776 @default.
• W2046657684 cites W17931924 @default.
• W2046657684 cites W1850986032 @default.
• W2046657684 cites W1965674955 @default.
• W2046657684 cites W1974061246 @default.
• W2046657684 cites W2019670695 @default.
• W2046657684 cites W2040812758 @default.
• W2046657684 cites W2051585680 @default.
• W2046657684 cites W2060710842 @default.
• W2046657684 cites W2075423986 @default.
• W2046657684 cites W2085374716 @default.
• W2046657684 cites W2104104631 @default.
• W2046657684 cites W2109483673 @default.
• W2046657684 cites W2118419827 @default.
• W2046657684 cites W2202733537 @default.
• W2046657684 cites W2281134048 @default.
• W2046657684 cites W2402635661 @default.
• W2046657684 cites W2417154503 @default.
• W2046657684 cites W2499505205 @default.
• W2046657684 doi "https://doi.org/10.1111/j.1432-1033.1974.tb03494.x" @default.
• W2046657684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4151857" @default.
• W2046657684 hasPublicationYear "1974" @default.
• W2046657684 type Work @default.
• W2046657684 sameAs 2046657684 @default.
• W2046657684 citedByCount "16" @default.
• W2046657684 countsByYear W20466576842018 @default.
• W2046657684 crossrefType "journal-article" @default.
• W2046657684 hasAuthorship W2046657684A5011456955 @default.
• W2046657684 hasAuthorship W2046657684A5040234310 @default.
• W2046657684 hasAuthorship W2046657684A5081151384 @default.
• W2046657684 hasBestOaLocation W20466576841 @default.
• W2046657684 hasConcept C132154277 @default.
• W2046657684 hasConcept C150903083 @default.
• W2046657684 hasConcept C153911025 @default.
• W2046657684 hasConcept C170493617 @default.
• W2046657684 hasConcept C181199279 @default.
• W2046657684 hasConcept C185592680 @default.
• W2046657684 hasConcept C202751555 @default.
• W2046657684 hasConcept C207001950 @default.
• W2046657684 hasConcept C25642318 @default.
• W2046657684 hasConcept C2776317432 @default.
• W2046657684 hasConcept C2776414213 @default.
• W2046657684 hasConcept C2776491826 @default.
• W2046657684 hasConcept C2777202666 @default.
• W2046657684 hasConcept C2777318727 @default.
• W2046657684 hasConcept C2779856020 @default.
• W2046657684 hasConcept C2781374117 @default.
• W2046657684 hasConcept C515207424 @default.
• W2046657684 hasConcept C55493867 @default.
• W2046657684 hasConcept C61174792 @default.
• W2046657684 hasConcept C86803240 @default.
• W2046657684 hasConceptScore W2046657684C132154277 @default.
• W2046657684 hasConceptScore W2046657684C150903083 @default.
• W2046657684 hasConceptScore W2046657684C153911025 @default.
• W2046657684 hasConceptScore W2046657684C170493617 @default.
• W2046657684 hasConceptScore W2046657684C181199279 @default.
• W2046657684 hasConceptScore W2046657684C185592680 @default.
• W2046657684 hasConceptScore W2046657684C202751555 @default.
• W2046657684 hasConceptScore W2046657684C207001950 @default.
• W2046657684 hasConceptScore W2046657684C25642318 @default.
• W2046657684 hasConceptScore W2046657684C2776317432 @default.
• W2046657684 hasConceptScore W2046657684C2776414213 @default.
• W2046657684 hasConceptScore W2046657684C2776491826 @default.
• W2046657684 hasConceptScore W2046657684C2777202666 @default.
• W2046657684 hasConceptScore W2046657684C2777318727 @default.
• W2046657684 hasConceptScore W2046657684C2779856020 @default.
• W2046657684 hasConceptScore W2046657684C2781374117 @default.
• W2046657684 hasConceptScore W2046657684C515207424 @default.
• W2046657684 hasConceptScore W2046657684C55493867 @default.
• W2046657684 hasConceptScore W2046657684C61174792 @default.
• W2046657684 hasConceptScore W2046657684C86803240 @default.
• W2046657684 hasIssue "2" @default.
• W2046657684 hasLocation W20466576841 @default.
• W2046657684 hasLocation W20466576842 @default.
• W2046657684 hasOpenAccess W2046657684 @default.
• W2046657684 hasPrimaryLocation W20466576841 @default.
• W2046657684 hasRelatedWork W1043451614 @default.
• W2046657684 hasRelatedWork W130010948 @default.
• W2046657684 hasRelatedWork W1973592190 @default.
• W2046657684 hasRelatedWork W1978059193 @default.
• W2046657684 hasRelatedWork W2032431389 @default.
• W2046657684 hasRelatedWork W2050078075 @default.
• W2046657684 hasRelatedWork W2374599087 @default.
• W2046657684 hasRelatedWork W2392887527 @default.
• W2046657684 hasRelatedWork W2401495086 @default.
• W2046657684 hasRelatedWork W752283992 @default.
• W2046657684 hasVolume "44" @default.
• W2046657684 isParatext "false" @default.

• next