Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046658051> ?p ?o ?g. }
- W2046658051 endingPage "1641" @default.
- W2046658051 startingPage "1635" @default.
- W2046658051 abstract "Cerebral hypoperfusion is a common feature of vascular dementia and has recently been recognized to contribute to the progression of cognitive decline. The present study aimed to investigate the effects of Bushen Huoxue decoction (BHD), a two‑herb Chinese Medicine, on cognitive impairment in a rat model of cerebral hypoperfusion induced by permanent occlusion of bilateral common carotid arteries (2VO). The results demonstrated that BHD significantly attenuated learning and spatial memory deficits in the Morris water maze test in a dose‑dependent manner. Transmission electron microscopy observation revealed that the reduction of synapse density in hippocampal CA1 and cortex parietal isolated from rats with 2VO was partially restored by BHD treatment. In addition, the expression levels of a number of antioxidants, including superoxide dismutase, catalase (CAT), glutathine and glutathione peroxidase‑1 (GPx‑1) increased, whereas malondialdehyde decreased in the hippocampi of rats with 2VO following BHD treatment. Polymerase chain reaction and western blot analysis further confirmed that the GPx‑1 and CAT expression increased in the BHD treatment group. In conclusion the results suggested that BHD has therapeutic potential to treat vascular dementia, which may be associated with synapse density and anti‑oxidant activities in the hippocampus." @default.
- W2046658051 created "2016-06-24" @default.
- W2046658051 creator A5007664752 @default.
- W2046658051 creator A5009235748 @default.
- W2046658051 creator A5011349887 @default.
- W2046658051 creator A5024525336 @default.
- W2046658051 creator A5037781435 @default.
- W2046658051 creator A5043111866 @default.
- W2046658051 creator A5070099567 @default.
- W2046658051 creator A5070822333 @default.
- W2046658051 creator A5071972213 @default.
- W2046658051 creator A5085222557 @default.
- W2046658051 date "2014-06-26" @default.
- W2046658051 modified "2023-10-14" @default.
- W2046658051 title "Bushen Huoxue decoction improves cognitive decline in rats with cerebral hypoperfusion" @default.
- W2046658051 cites W1519306389 @default.
- W2046658051 cites W1586864671 @default.
- W2046658051 cites W1733078847 @default.
- W2046658051 cites W1848036686 @default.
- W2046658051 cites W1900968643 @default.
- W2046658051 cites W1912107779 @default.
- W2046658051 cites W1967061503 @default.
- W2046658051 cites W1995756267 @default.
- W2046658051 cites W1997890651 @default.
- W2046658051 cites W2001632769 @default.
- W2046658051 cites W2003535757 @default.
- W2046658051 cites W2007804566 @default.
- W2046658051 cites W2013739229 @default.
- W2046658051 cites W2015418819 @default.
- W2046658051 cites W2015933608 @default.
- W2046658051 cites W2016550542 @default.
- W2046658051 cites W2027362156 @default.
- W2046658051 cites W2029186905 @default.
- W2046658051 cites W2043838674 @default.
- W2046658051 cites W2044799784 @default.
- W2046658051 cites W2056492953 @default.
- W2046658051 cites W2063220512 @default.
- W2046658051 cites W2066030554 @default.
- W2046658051 cites W2076880790 @default.
- W2046658051 cites W2086523759 @default.
- W2046658051 cites W2089346722 @default.
- W2046658051 cites W2097033739 @default.
- W2046658051 cites W2102198125 @default.
- W2046658051 cites W2104233676 @default.
- W2046658051 cites W2109273933 @default.
- W2046658051 cites W2127578307 @default.
- W2046658051 cites W2147162166 @default.
- W2046658051 cites W2169473035 @default.
- W2046658051 cites W2172074865 @default.
- W2046658051 cites W4210993281 @default.
- W2046658051 cites W4320801180 @default.
- W2046658051 doi "https://doi.org/10.3892/mmr.2014.2355" @default.
- W2046658051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24968700" @default.
- W2046658051 hasPublicationYear "2014" @default.
- W2046658051 type Work @default.
- W2046658051 sameAs 2046658051 @default.
- W2046658051 citedByCount "9" @default.
- W2046658051 countsByYear W20466580512016 @default.
- W2046658051 countsByYear W20466580512018 @default.
- W2046658051 countsByYear W20466580512019 @default.
- W2046658051 countsByYear W20466580512020 @default.
- W2046658051 countsByYear W20466580512022 @default.
- W2046658051 countsByYear W20466580512023 @default.
- W2046658051 crossrefType "journal-article" @default.
- W2046658051 hasAuthorship W2046658051A5007664752 @default.
- W2046658051 hasAuthorship W2046658051A5009235748 @default.
- W2046658051 hasAuthorship W2046658051A5011349887 @default.
- W2046658051 hasAuthorship W2046658051A5024525336 @default.
- W2046658051 hasAuthorship W2046658051A5037781435 @default.
- W2046658051 hasAuthorship W2046658051A5043111866 @default.
- W2046658051 hasAuthorship W2046658051A5070099567 @default.
- W2046658051 hasAuthorship W2046658051A5070822333 @default.
- W2046658051 hasAuthorship W2046658051A5071972213 @default.
- W2046658051 hasAuthorship W2046658051A5085222557 @default.
- W2046658051 hasBestOaLocation W20466580511 @default.
- W2046658051 hasConcept C126322002 @default.
- W2046658051 hasConcept C134018914 @default.
- W2046658051 hasConcept C190409667 @default.
- W2046658051 hasConcept C2775838275 @default.
- W2046658051 hasConcept C2776151105 @default.
- W2046658051 hasConcept C2777952318 @default.
- W2046658051 hasConcept C2778401633 @default.
- W2046658051 hasConcept C2778760513 @default.
- W2046658051 hasConcept C2779134260 @default.
- W2046658051 hasConcept C2779483572 @default.
- W2046658051 hasConcept C2780749935 @default.
- W2046658051 hasConcept C2781161787 @default.
- W2046658051 hasConcept C2984863031 @default.
- W2046658051 hasConcept C2984915365 @default.
- W2046658051 hasConcept C42219234 @default.
- W2046658051 hasConcept C44752575 @default.
- W2046658051 hasConcept C71924100 @default.
- W2046658051 hasConcept C98274493 @default.
- W2046658051 hasConceptScore W2046658051C126322002 @default.
- W2046658051 hasConceptScore W2046658051C134018914 @default.
- W2046658051 hasConceptScore W2046658051C190409667 @default.
- W2046658051 hasConceptScore W2046658051C2775838275 @default.
- W2046658051 hasConceptScore W2046658051C2776151105 @default.