FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046667138> ?p ?o ?g. }

• W2046667138 abstract "Topoisomerase IIalpha (Topo IIalpha) is an essential nuclear enzyme with a role in the maintenance of DNA topology. Topo IIalpha is a target for several anticancer drugs and the levels of activity of this enzyme have been implicated in the development of drug resistance. Our objective was to identify regulatory transcription factors involved in drug-induced down-regulation of Topo IIalpha. A breast cancer cell line was subjected to a pulsed exposure of doxorubicin and resistant clones propagated. Whole-cell extracts were studied by immunoblotting and RT-PCR for drug-induced changes in the amounts Topo IIalpha, Sp1, Sp3, NF-Y and MDR1. Topo IIalpha levels were reduced in six out of eight cell lines. Of these, three showed concomitant changes in the expression of Sp1 and NF-YA. Thus, we provide the first evidence for roles of Sp1 and NF-Y in bringing about the drug-induced down-regulation of Topo IIalpha gene expression." @default.
• W2046667138 created "2016-06-24" @default.
• W2046667138 creator A5005021921 @default.
• W2046667138 creator A5005590357 @default.
• W2046667138 creator A5043903784 @default.
• W2046667138 creator A5055147773 @default.
• W2046667138 date "2004-04-01" @default.
• W2046667138 modified "2023-09-27" @default.
• W2046667138 title "Down-regulation of human topoisomerase IIα correlates with altered expression of transcriptional regulators NF-YA and Sp1" @default.
• W2046667138 cites W1485126530 @default.
• W2046667138 cites W1512813342 @default.
• W2046667138 cites W1542132500 @default.
• W2046667138 cites W1971175458 @default.
• W2046667138 cites W1982477267 @default.
• W2046667138 cites W1984824591 @default.
• W2046667138 cites W1986621896 @default.
• W2046667138 cites W1987388786 @default.
• W2046667138 cites W2018862418 @default.
• W2046667138 cites W2023528629 @default.
• W2046667138 cites W2028908766 @default.
• W2046667138 cites W2030663566 @default.
• W2046667138 cites W2041816036 @default.
• W2046667138 cites W2043435962 @default.
• W2046667138 cites W2049104063 @default.
• W2046667138 cites W2057714371 @default.
• W2046667138 cites W2062671754 @default.
• W2046667138 cites W2085043108 @default.
• W2046667138 cites W2088622701 @default.
• W2046667138 cites W2090421237 @default.
• W2046667138 cites W2094747148 @default.
• W2046667138 cites W2103375481 @default.
• W2046667138 cites W2221459232 @default.
• W2046667138 cites W2340724358 @default.
• W2046667138 doi "https://doi.org/10.1097/00001813-200404000-00008" @default.
• W2046667138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15057140" @default.
• W2046667138 hasPublicationYear "2004" @default.
• W2046667138 type Work @default.
• W2046667138 sameAs 2046667138 @default.
• W2046667138 citedByCount "9" @default.
• W2046667138 countsByYear W20466671382012 @default.
• W2046667138 crossrefType "journal-article" @default.
• W2046667138 hasAuthorship W2046667138A5005021921 @default.
• W2046667138 hasAuthorship W2046667138A5005590357 @default.
• W2046667138 hasAuthorship W2046667138A5043903784 @default.
• W2046667138 hasAuthorship W2046667138A5055147773 @default.
• W2046667138 hasConcept C101762097 @default.
• W2046667138 hasConcept C104317684 @default.
• W2046667138 hasConcept C138885662 @default.
• W2046667138 hasConcept C147897179 @default.
• W2046667138 hasConcept C150194340 @default.
• W2046667138 hasConcept C153911025 @default.
• W2046667138 hasConcept C179926584 @default.
• W2046667138 hasConcept C181199279 @default.
• W2046667138 hasConcept C27153228 @default.
• W2046667138 hasConcept C2776694085 @default.
• W2046667138 hasConcept C2781303535 @default.
• W2046667138 hasConcept C41895202 @default.
• W2046667138 hasConcept C502942594 @default.
• W2046667138 hasConcept C54355233 @default.
• W2046667138 hasConcept C55493867 @default.
• W2046667138 hasConcept C57467964 @default.
• W2046667138 hasConcept C81885089 @default.
• W2046667138 hasConcept C86339819 @default.
• W2046667138 hasConcept C86803240 @default.
• W2046667138 hasConcept C95444343 @default.
• W2046667138 hasConceptScore W2046667138C101762097 @default.
• W2046667138 hasConceptScore W2046667138C104317684 @default.
• W2046667138 hasConceptScore W2046667138C138885662 @default.
• W2046667138 hasConceptScore W2046667138C147897179 @default.
• W2046667138 hasConceptScore W2046667138C150194340 @default.
• W2046667138 hasConceptScore W2046667138C153911025 @default.
• W2046667138 hasConceptScore W2046667138C179926584 @default.
• W2046667138 hasConceptScore W2046667138C181199279 @default.
• W2046667138 hasConceptScore W2046667138C27153228 @default.
• W2046667138 hasConceptScore W2046667138C2776694085 @default.
• W2046667138 hasConceptScore W2046667138C2781303535 @default.
• W2046667138 hasConceptScore W2046667138C41895202 @default.
• W2046667138 hasConceptScore W2046667138C502942594 @default.
• W2046667138 hasConceptScore W2046667138C54355233 @default.
• W2046667138 hasConceptScore W2046667138C55493867 @default.
• W2046667138 hasConceptScore W2046667138C57467964 @default.
• W2046667138 hasConceptScore W2046667138C81885089 @default.
• W2046667138 hasConceptScore W2046667138C86339819 @default.
• W2046667138 hasConceptScore W2046667138C86803240 @default.
• W2046667138 hasConceptScore W2046667138C95444343 @default.
• W2046667138 hasLocation W20466671381 @default.
• W2046667138 hasLocation W20466671382 @default.
• W2046667138 hasOpenAccess W2046667138 @default.
• W2046667138 hasPrimaryLocation W20466671381 @default.
• W2046667138 hasRelatedWork W1523914420 @default.
• W2046667138 hasRelatedWork W1991111392 @default.
• W2046667138 hasRelatedWork W2051030376 @default.
• W2046667138 hasRelatedWork W2056013470 @default.
• W2046667138 hasRelatedWork W2060074596 @default.
• W2046667138 hasRelatedWork W2117350062 @default.
• W2046667138 hasRelatedWork W2374726964 @default.
• W2046667138 hasRelatedWork W2516413931 @default.
• W2046667138 hasRelatedWork W2986610122 @default.
• W2046667138 hasRelatedWork W2083042705 @default.
• W2046667138 isParatext "false" @default.

• next