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- W20466723 abstract "textabstractOver the last ten years hyperthermia has been introduced as an experimentaltherapy that is available to the clinician in the treatment of malignantdisease. Intensive experimental and clinical research is continuing intovarious aspects of treatment.Since the importance of enviromental factors in hyperthemic cellulardestruction was realised, a largestudies aimed at ellucidating thenumber of investigators have undertakenrole of hyperthermia on cells under theinfluence of such factors as nutrition, oxygenation and hydrogen ionconcentration. Investigations are continuing into temperature/timerelationships for killing of both normal and malignant tissues, while otherstudies are focusing attention on heat dose fractionation and thermal inducedthermal resistance.Efforts have been made to achieve greater understanding of the structureand functioional limitations of tumor microcirculation, of disturbancesbrought about in it during hyperthermia, and the resultant changes occurring inoxygenation and acid base balance at the local level.Additional studies are in progress with the aim of investigating the role ofhyperthermia in potentiating damage to normal and malignant tissues broughtabout by radiotherapy and the sequential effects of the two modalities. Theeffects of combined chemotherapy and thermotherapy are also under intensiveinvestigation" @default.
- W20466723 created "2016-06-24" @default.
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- W20466723 date "1983-03-23" @default.
- W20466723 modified "2023-09-24" @default.
- W20466723 title "Hyperthermia : physiological changes associated with whole body hyperthermia for cancer treatment" @default.
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