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- W2046677458 abstract "3,p<0.001). Nine (9%) clozapine patients and no healthy controls or non-clozapine patients, had LVEF <50%. In the clozapine group, multivariate analysis showed elevated neutrophil countand low HDL-cholesterolasthe onlyindependentassociationswithimpairedLS. Platelet count, D-dimer and fibrinogen levels did not differ between controls and patients with schizophrenia.Incontrast,theoverallcoagulationpotential(54.0� 12.6vs45.9� 9.1,p¼0.002), overallhaemostaticpotential(12.6� 5.8vs7.2� 3.7,p<0.001),andoverall fibrinolyticpotential (76.6� 9.8% vs 84.9� 6.4%,p<0.001) were all significantly different in patients with schizophrenia compared to controls and were unaffected by clozapine use. Conclusion: Asymptomatic LV impairment is common in patients with schizophrenia receiving long-term clozapine, and is associated with neutrophilia and low plasma HDL suggesting an inflammatory link. There is also a hypercoagulable and hypofibrinolytic state in patients with schizophrenia unrelated to specific clozapine use. Disclosure of Interest: V. Chow: None Declared, T. Yeoh: None Declared, A. C. C. Ng: None Declared, T. Pasqualon: None Declared, E. Scott: None Declared, T. Chung: None Declared, L. Thomas: None Declared, J. Curnow Consultancy for: Haematology consultative services to Novartis for the clozaril patient monitoring service, D. Celermajer: None Declared, L. Kritharides: None Declared" @default.
- W2046677458 created "2016-06-24" @default.
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- W2046677458 date "2014-03-01" @default.
- W2046677458 modified "2023-09-27" @default.
- W2046677458 title "PT054 The safety and efficacy of prednisolone in preventing re-accumulation of ascites among EMF patients at Mulago Hospital: A randomised clinical trial(pilot)" @default.
- W2046677458 doi "https://doi.org/10.1016/j.gheart.2014.03.1856" @default.
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