Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046680400> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2046680400 endingPage "13" @default.
- W2046680400 startingPage "8" @default.
- W2046680400 abstract "Article AbstractCognitive impairment is a core feature of schizophrenia that is present across the course of the illness. However, due to complexities of studying cognitive decline in patients prior to the onset of illness, the longitudinal course is not fully understood. The cognitive effects in patients with schizophrenia are robust, with a 1.5 to 2.5 standard deviation gap between patients and healthy controls on composite scores. People with schizophrenia manifest a prior history of cognitive impairment in the premorbid phases of the illness. Examination of school records suggests that children who will eventually develop schizophrenia begin school at a level of functioning that is a full grade behind their peers, with the gap increasing by the time they finish high school. Epidemiologic work suggests that there are both static cognitive impairments and developmental lags in these patients during childhood, well before the illness is fully manifest. Although there was initial promise of improved cognitive function with second-generation antipsychotic treatment, more recent studies have suggested no differences among antipsychotics, with the initial appearance of improvement very likely attributable to practice effects, inappropriate medication dosing, and poor study design. Two large, prominent studies evaluating first- and second-generation antipsychotics suggested that, although there was slight to modest improvement in cognitive function for all treatments, there were no differences among medications, regardless of the generation of the agents. In summary, patients who develop schizophrenia, on average, demonstrate cognitive impairment beginning as early as the first grade, with deterioration seen across school years. Further, these patients had substantial cognitive deficits after the initiation of psychosis. Finally, while antipsychotic treatment improves symptoms, antipsychotics have little impact on cognition, and there appear to be no differences in the degree of cognitive improvement between first- and second-generation agents." @default.
- W2046680400 created "2016-06-24" @default.
- W2046680400 creator A5026643447 @default.
- W2046680400 date "2014-05-01" @default.
- W2046680400 modified "2023-10-14" @default.
- W2046680400 title "The Longitudinal Course of Cognitive Impairment in Schizophrenia" @default.
- W2046680400 doi "https://doi.org/10.4088/jcp.13065su1.02" @default.
- W2046680400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24919165" @default.
- W2046680400 hasPublicationYear "2014" @default.
- W2046680400 type Work @default.
- W2046680400 sameAs 2046680400 @default.
- W2046680400 citedByCount "89" @default.
- W2046680400 countsByYear W20466804002014 @default.
- W2046680400 countsByYear W20466804002015 @default.
- W2046680400 countsByYear W20466804002016 @default.
- W2046680400 countsByYear W20466804002017 @default.
- W2046680400 countsByYear W20466804002018 @default.
- W2046680400 countsByYear W20466804002019 @default.
- W2046680400 countsByYear W20466804002020 @default.
- W2046680400 countsByYear W20466804002021 @default.
- W2046680400 countsByYear W20466804002022 @default.
- W2046680400 countsByYear W20466804002023 @default.
- W2046680400 crossrefType "journal-article" @default.
- W2046680400 hasAuthorship W2046680400A5026643447 @default.
- W2046680400 hasBestOaLocation W20466804001 @default.
- W2046680400 hasConcept C118552586 @default.
- W2046680400 hasConcept C134362201 @default.
- W2046680400 hasConcept C15744967 @default.
- W2046680400 hasConcept C169900460 @default.
- W2046680400 hasConcept C2776412080 @default.
- W2046680400 hasConcept C2776674806 @default.
- W2046680400 hasConcept C2780494398 @default.
- W2046680400 hasConcept C70410870 @default.
- W2046680400 hasConcept C71924100 @default.
- W2046680400 hasConceptScore W2046680400C118552586 @default.
- W2046680400 hasConceptScore W2046680400C134362201 @default.
- W2046680400 hasConceptScore W2046680400C15744967 @default.
- W2046680400 hasConceptScore W2046680400C169900460 @default.
- W2046680400 hasConceptScore W2046680400C2776412080 @default.
- W2046680400 hasConceptScore W2046680400C2776674806 @default.
- W2046680400 hasConceptScore W2046680400C2780494398 @default.
- W2046680400 hasConceptScore W2046680400C70410870 @default.
- W2046680400 hasConceptScore W2046680400C71924100 @default.
- W2046680400 hasIssue "suppl 2" @default.
- W2046680400 hasLocation W20466804001 @default.
- W2046680400 hasLocation W20466804002 @default.
- W2046680400 hasOpenAccess W2046680400 @default.
- W2046680400 hasPrimaryLocation W20466804001 @default.
- W2046680400 hasRelatedWork W2038698792 @default.
- W2046680400 hasRelatedWork W2044398915 @default.
- W2046680400 hasRelatedWork W2110640372 @default.
- W2046680400 hasRelatedWork W2157772778 @default.
- W2046680400 hasRelatedWork W2292275194 @default.
- W2046680400 hasRelatedWork W2474679401 @default.
- W2046680400 hasRelatedWork W2903287184 @default.
- W2046680400 hasRelatedWork W3174036944 @default.
- W2046680400 hasRelatedWork W403513690 @default.
- W2046680400 hasRelatedWork W4248764635 @default.
- W2046680400 hasVolume "75" @default.
- W2046680400 isParatext "false" @default.
- W2046680400 isRetracted "false" @default.
- W2046680400 magId "2046680400" @default.
- W2046680400 workType "article" @default.