Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046688695> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2046688695 endingPage "367" @default.
- W2046688695 startingPage "364" @default.
- W2046688695 abstract "Early forms of high-density lipoproteins (HDL), nascent HDL, are formed by the interaction of apolipoprotein AI with macrophage and hepatic ATP-binding cassette transporter member 1. Various plasma activities convert nascent to mature HDL, comprising phosphatidylcholine (PC) and cholesterol, which are selectively removed by hepatic receptors. This process is important in reducing the cholesterol burden of arterial wall macrophages, an important cell type in all stages of atherosclerosis. Interaction of apolipoprotein AI with dimyristoyl (DM)PC forms reconstituted (r)HDL, which is a good model of nascent HDL. rHDL have been used as an antiathersclerosis therapy that enhances reverse cholesterol transport in humans and animal models. Thus, identification of the structure of rHDL would inform about that of nascent HDL and how rHDL improves reverse cholesterol transport in an atheroprotective way. Early studies of rHDL suggested a discoidal structure, which included pairs of antiparallel helices of apolipoprotein AI circumscribing a phospholipid bilayer. Another rHDL model based on small angle neutron scattering supported a double superhelical structure. Herein, we report a cryo-electron microscopy-based model of a large rHDL formed spontaneously from apolipoprotein AI, cholesterol, and excess DMPC and isolated to near homogeneity. After reconstruction we obtained an rHDL structure comprising DMPC, cholesterol, and apolipoprotein AI (423:74:1 mol/mol) forming a discoidal particle 360 Å in diameter and 45 Å thick; these dimensions are consistent with the stoichiometry of the particles. Given that cryo-electron microscopy directly observes projections of individual rHDL particles in different orientations, we can unambiguously state that rHDL particles are protein bounded discoidal bilayers." @default.
- W2046688695 created "2016-06-24" @default.
- W2046688695 creator A5083384406 @default.
- W2046688695 creator A5091206818 @default.
- W2046688695 date "1970-05-01" @default.
- W2046688695 modified "2023-09-26" @default.
- W2046688695 title "Reassembly in vitro of a serum high-density lipoprotein" @default.
- W2046688695 cites W1561164143 @default.
- W2046688695 cites W1579655741 @default.
- W2046688695 cites W1988738419 @default.
- W2046688695 cites W1998518729 @default.
- W2046688695 cites W2038547942 @default.
- W2046688695 cites W2061129195 @default.
- W2046688695 cites W2073062158 @default.
- W2046688695 cites W2181301753 @default.
- W2046688695 cites W2320288428 @default.
- W2046688695 cites W2344308696 @default.
- W2046688695 cites W2394848232 @default.
- W2046688695 cites W4253654177 @default.
- W2046688695 cites W4322696518 @default.
- W2046688695 doi "https://doi.org/10.1016/0005-2795(70)90029-2" @default.
- W2046688695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4989610" @default.
- W2046688695 hasPublicationYear "1970" @default.
- W2046688695 type Work @default.
- W2046688695 sameAs 2046688695 @default.
- W2046688695 citedByCount "73" @default.
- W2046688695 countsByYear W20466886952013 @default.
- W2046688695 countsByYear W20466886952014 @default.
- W2046688695 countsByYear W20466886952015 @default.
- W2046688695 countsByYear W20466886952016 @default.
- W2046688695 countsByYear W20466886952023 @default.
- W2046688695 crossrefType "journal-article" @default.
- W2046688695 hasAuthorship W2046688695A5083384406 @default.
- W2046688695 hasAuthorship W2046688695A5091206818 @default.
- W2046688695 hasConcept C110459506 @default.
- W2046688695 hasConcept C115260700 @default.
- W2046688695 hasConcept C121332964 @default.
- W2046688695 hasConcept C12554922 @default.
- W2046688695 hasConcept C142089489 @default.
- W2046688695 hasConcept C185592680 @default.
- W2046688695 hasConcept C192157962 @default.
- W2046688695 hasConcept C2776330855 @default.
- W2046688695 hasConcept C2778163477 @default.
- W2046688695 hasConcept C2778918659 @default.
- W2046688695 hasConcept C2780072125 @default.
- W2046688695 hasConcept C41625074 @default.
- W2046688695 hasConcept C55493867 @default.
- W2046688695 hasConcept C62520636 @default.
- W2046688695 hasConcept C62746215 @default.
- W2046688695 hasConcept C8010536 @default.
- W2046688695 hasConcept C86803240 @default.
- W2046688695 hasConceptScore W2046688695C110459506 @default.
- W2046688695 hasConceptScore W2046688695C115260700 @default.
- W2046688695 hasConceptScore W2046688695C121332964 @default.
- W2046688695 hasConceptScore W2046688695C12554922 @default.
- W2046688695 hasConceptScore W2046688695C142089489 @default.
- W2046688695 hasConceptScore W2046688695C185592680 @default.
- W2046688695 hasConceptScore W2046688695C192157962 @default.
- W2046688695 hasConceptScore W2046688695C2776330855 @default.
- W2046688695 hasConceptScore W2046688695C2778163477 @default.
- W2046688695 hasConceptScore W2046688695C2778918659 @default.
- W2046688695 hasConceptScore W2046688695C2780072125 @default.
- W2046688695 hasConceptScore W2046688695C41625074 @default.
- W2046688695 hasConceptScore W2046688695C55493867 @default.
- W2046688695 hasConceptScore W2046688695C62520636 @default.
- W2046688695 hasConceptScore W2046688695C62746215 @default.
- W2046688695 hasConceptScore W2046688695C8010536 @default.
- W2046688695 hasConceptScore W2046688695C86803240 @default.
- W2046688695 hasIssue "2" @default.
- W2046688695 hasLocation W20466886951 @default.
- W2046688695 hasLocation W20466886952 @default.
- W2046688695 hasOpenAccess W2046688695 @default.
- W2046688695 hasPrimaryLocation W20466886951 @default.
- W2046688695 hasRelatedWork W1975826912 @default.
- W2046688695 hasRelatedWork W1996118670 @default.
- W2046688695 hasRelatedWork W2023418526 @default.
- W2046688695 hasRelatedWork W2065777224 @default.
- W2046688695 hasRelatedWork W2071712542 @default.
- W2046688695 hasRelatedWork W2090795111 @default.
- W2046688695 hasRelatedWork W2122673417 @default.
- W2046688695 hasRelatedWork W2271298233 @default.
- W2046688695 hasRelatedWork W2417273016 @default.
- W2046688695 hasRelatedWork W2784780221 @default.
- W2046688695 hasVolume "207" @default.
- W2046688695 isParatext "false" @default.
- W2046688695 isRetracted "false" @default.
- W2046688695 magId "2046688695" @default.
- W2046688695 workType "article" @default.