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- W2046691399 endingPage "e0118434" @default.
- W2046691399 startingPage "e0118434" @default.
- W2046691399 abstract "Ebolaviruses can cause severe hemorrhagic fever that is characterized by rapid viral replication, coagulopathy, inflammation, and high lethality rates. Although there is no clinically proven vaccine or treatment for Ebola virus infection, a virus-like particle (VLP) vaccine is effective in mice, guinea pigs, and non-human primates when given pre-infection. In this work, we report that VLPs protect Ebola virus-infected mice when given 24 hours post-infection. Analysis of cytokine expression in serum revealed a decrease in pro-inflammatory cytokine and chemokine levels in mice given VLPs post-exposure compared to infected, untreated mice. Using knockout mice, we show that VLP-mediated post-exposure protection requires perforin, B cells, macrophages, conventional dendritic cells (cDCs), and either CD4+ or CD8+ T cells. Protection was Ebola virus-specific, as marburgvirus VLPs did not protect Ebola virus-infected mice. Increased antibody production in VLP-treated mice correlated with protection, and macrophages were required for this increased production. However, NK cells, IFN-gamma, and TNF-alpha were not required for post-exposure-mediated protection. These data suggest that a non-replicating Ebola virus vaccine can provide post-exposure protection and that the mechanisms of immune protection in this setting require both increased antibody production and generation of cytotoxic T cells." @default.
- W2046691399 created "2016-06-24" @default.
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- W2046691399 date "2015-03-18" @default.
- W2046691399 modified "2023-09-25" @default.
- W2046691399 title "Mechanisms of Immunity in Post-Exposure Vaccination against Ebola Virus Infection" @default.
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- W2046691399 cites W1921161048 @default.
- W2046691399 cites W1963612974 @default.
- W2046691399 cites W1966742128 @default.
- W2046691399 cites W1974991710 @default.
- W2046691399 cites W1982830459 @default.
- W2046691399 cites W1986492410 @default.
- W2046691399 cites W1997936078 @default.
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- W2046691399 cites W2024533319 @default.
- W2046691399 cites W2024814551 @default.
- W2046691399 cites W2028303888 @default.
- W2046691399 cites W2028463307 @default.
- W2046691399 cites W2030292647 @default.
- W2046691399 cites W2033815173 @default.
- W2046691399 cites W2041402370 @default.
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- W2046691399 cites W2048186359 @default.
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- W2046691399 cites W2096397419 @default.
- W2046691399 cites W2103863906 @default.
- W2046691399 cites W2103992594 @default.
- W2046691399 cites W2107370389 @default.
- W2046691399 cites W2108394482 @default.
- W2046691399 cites W2109457824 @default.
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- W2046691399 cites W2125615308 @default.
- W2046691399 cites W2125684318 @default.
- W2046691399 cites W2128406623 @default.
- W2046691399 cites W2130268772 @default.
- W2046691399 cites W2136287414 @default.
- W2046691399 cites W2141122594 @default.
- W2046691399 cites W2141797473 @default.
- W2046691399 cites W2148892550 @default.
- W2046691399 cites W2149902587 @default.
- W2046691399 cites W2155376686 @default.
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- W2046691399 cites W2161222943 @default.
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- W2046691399 cites W23995963 @default.
- W2046691399 cites W2868963225 @default.
- W2046691399 cites W4235411503 @default.
- W2046691399 cites W4238915259 @default.
- W2046691399 cites W4250007760 @default.
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- W2046691399 doi "https://doi.org/10.1371/journal.pone.0118434" @default.
- W2046691399 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4364937" @default.
- W2046691399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25785602" @default.
- W2046691399 hasPublicationYear "2015" @default.
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