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• W2046702983 abstract "Guerrero JM, Reiter RJ, Poeggeler B, Chen L-D, Tan D-X. Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide. J Pineal Res. 1994:16:210–214. The present paper reports that nitric oxide (NO) released by sodium nitroprusside (SNP) is a potent activator of rat pineal cyclic GMP production without affecting cyclic AMP synthesis. Other drugs such as isoproterenol, vasoactive intestinal peptide, and peptide histidine isoleucine were ineffective in stimulating cyclic GMP production, but activated cyclic AMP production. However, L-arginine, the physiological precursor of NO, did not activate either cyclic GMP or NO synthesis. Because L-arginine failed to activate cyclic GMP production, results suggest that NO is not produced in the pineal gland, but behaves as a potent regulator of this cyclic nucleotide." @default.
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• W2046702983 date "1994-05-01" @default.
• W2046702983 modified "2023-10-18" @default.
• W2046702983 title "Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide" @default.
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• W2046702983 doi "https://doi.org/10.1111/j.1600-079x.1994.tb00104.x" @default.
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