FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046705160> ?p ?o ?g. }

• W2046705160 endingPage "946" @default.
• W2046705160 startingPage "933" @default.
• W2046705160 abstract "In Candida albicans, the transcription factor Upc2 is central to the regulation of ergosterol biosynthesis. UPC2-activating mutations contribute to azole resistance, whereas disruption increases azole susceptibility. In the present study, we investigated the relationship of UPC2 to fluconazole susceptibility, particularly in azole-resistant strains. In addition to the reduced fluconazole MIC previously observed with UPC2 disruption, we observed a lower minimum fungicidal concentration (MFC) for a upc2Δ/Δ mutant than for its azole-susceptible parent, SC5314. Moreover, the upc2Δ/Δ mutant was unable to grow on a solid medium containing 10 μg/ml fluconazole and exhibited increased susceptibility and a clear zone of inhibition by Etest. Time-kill analysis showed higher fungistatic activity against the upc2Δ/Δ mutant than against SC5314. UPC2 disruption in strains carrying specific resistance mutations also resulted in reduced MICs and MFCs. UPC2 disruption in a highly azole resistant clinical isolate containing multiple resistance mechanisms likewise resulted in a reduced MIC and MFC. This mutant was unable to grow on a solid medium containing 10 μg/ml fluconazole and exhibited increased susceptibility and a clear zone of inhibition by Etest. Time-kill analysis showed increased fungistatic activity against the upc2Δ/Δ mutant in the resistant background. Microarray analysis showed attenuated induction by fluconazole of genes involved in sterol biosynthesis, iron transport, or iron homeostasis in the absence of UPC2. Taken together, these data demonstrate that the UPC2 transcriptional network is universally essential for azole resistance in C. albicans and represents an attractive target for enhancing azole antifungal activity." @default.
• W2046705160 created "2016-06-24" @default.
• W2046705160 creator A5016456903 @default.
• W2046705160 creator A5059280370 @default.
• W2046705160 creator A5067297104 @default.
• W2046705160 creator A5080833703 @default.
• W2046705160 creator A5082260796 @default.
• W2046705160 date "2014-07-01" @default.
• W2046705160 modified "2023-10-14" @default.
• W2046705160 title "<i>UPC2</i> Is Universally Essential for Azole Antifungal Resistance in Candida albicans" @default.
• W2046705160 cites W1893975279 @default.
• W2046705160 cites W1905535572 @default.
• W2046705160 cites W1964581982 @default.
• W2046705160 cites W1969365827 @default.
• W2046705160 cites W1971071885 @default.
• W2046705160 cites W1972208703 @default.
• W2046705160 cites W1979749196 @default.
• W2046705160 cites W1989849863 @default.
• W2046705160 cites W1990474165 @default.
• W2046705160 cites W2001756812 @default.
• W2046705160 cites W2004111147 @default.
• W2046705160 cites W2004193133 @default.
• W2046705160 cites W2008837893 @default.
• W2046705160 cites W2011877381 @default.
• W2046705160 cites W2012100139 @default.
• W2046705160 cites W2026687517 @default.
• W2046705160 cites W2029796144 @default.
• W2046705160 cites W2044666681 @default.
• W2046705160 cites W2058240781 @default.
• W2046705160 cites W2072883087 @default.
• W2046705160 cites W2097771377 @default.
• W2046705160 cites W2098563304 @default.
• W2046705160 cites W2102213954 @default.
• W2046705160 cites W2104107099 @default.
• W2046705160 cites W2107013040 @default.
• W2046705160 cites W2107043911 @default.
• W2046705160 cites W2107739336 @default.
• W2046705160 cites W2109056652 @default.
• W2046705160 cites W2109476076 @default.
• W2046705160 cites W2115769369 @default.
• W2046705160 cites W2116296015 @default.
• W2046705160 cites W2117461892 @default.
• W2046705160 cites W2118236446 @default.
• W2046705160 cites W2123559285 @default.
• W2046705160 cites W2125823722 @default.
• W2046705160 cites W2126656381 @default.
• W2046705160 cites W2127080406 @default.
• W2046705160 cites W2129494864 @default.
• W2046705160 cites W2135182325 @default.
• W2046705160 cites W2140936126 @default.
• W2046705160 cites W2144149632 @default.
• W2046705160 cites W2147739065 @default.
• W2046705160 cites W2149000422 @default.
• W2046705160 cites W2149220964 @default.
• W2046705160 cites W2157149808 @default.
• W2046705160 cites W2157937554 @default.
• W2046705160 cites W2158345992 @default.
• W2046705160 cites W2162171804 @default.
• W2046705160 cites W2169755129 @default.
• W2046705160 cites W2336541137 @default.
• W2046705160 doi "https://doi.org/10.1128/ec.00221-13" @default.
• W2046705160 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4135735" @default.
• W2046705160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24659578" @default.
• W2046705160 hasPublicationYear "2014" @default.
• W2046705160 type Work @default.
• W2046705160 sameAs 2046705160 @default.
• W2046705160 citedByCount "49" @default.
• W2046705160 countsByYear W20467051602014 @default.
• W2046705160 countsByYear W20467051602015 @default.
• W2046705160 countsByYear W20467051602016 @default.
• W2046705160 countsByYear W20467051602017 @default.
• W2046705160 countsByYear W20467051602018 @default.
• W2046705160 countsByYear W20467051602019 @default.
• W2046705160 countsByYear W20467051602020 @default.
• W2046705160 countsByYear W20467051602021 @default.
• W2046705160 countsByYear W20467051602022 @default.
• W2046705160 countsByYear W20467051602023 @default.
• W2046705160 crossrefType "journal-article" @default.
• W2046705160 hasAuthorship W2046705160A5016456903 @default.
• W2046705160 hasAuthorship W2046705160A5059280370 @default.
• W2046705160 hasAuthorship W2046705160A5067297104 @default.
• W2046705160 hasAuthorship W2046705160A5080833703 @default.
• W2046705160 hasAuthorship W2046705160A5082260796 @default.
• W2046705160 hasBestOaLocation W20467051601 @default.
• W2046705160 hasConcept C104317684 @default.
• W2046705160 hasConcept C143065580 @default.
• W2046705160 hasConcept C2779548794 @default.
• W2046705160 hasConcept C2780315139 @default.
• W2046705160 hasConcept C2780651595 @default.
• W2046705160 hasConcept C2780917455 @default.
• W2046705160 hasConcept C501593827 @default.
• W2046705160 hasConcept C55493867 @default.
• W2046705160 hasConcept C81396022 @default.
• W2046705160 hasConcept C86803240 @default.
• W2046705160 hasConcept C89423630 @default.
• W2046705160 hasConceptScore W2046705160C104317684 @default.
• W2046705160 hasConceptScore W2046705160C143065580 @default.
• W2046705160 hasConceptScore W2046705160C2779548794 @default.

• next