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- W2046706654 endingPage "52" @default.
- W2046706654 startingPage "44" @default.
- W2046706654 abstract "Neuropeptides act as signaling molecules that regulate a range of aspects of brain function. Gastrin-releasing peptide (GRP) is a 27-amino acid mammalian neuropeptide, homolog of the amphibian peptide bombesin. GRP acts by binding to the GRP receptor (GRPR, also called BB2), a member of the G-protein coupled receptor (GPCR) superfamily. GRP produced by neurons in the central nervous system (CNS) plays a role in synaptic transmission by activating GRPRs located on postsynaptic membranes, influencing several aspects of brain function. Here we review the role of GRP/GRPR as a system mediating both stress responses and the formation and expression of memories for fearful events. GRPR signaling might integrate the processing of stress and fear with synaptic plasticity and memory, serving as an important component of the set of neurobiological systems underlying the enhancement of memory storage by aversive information." @default.
- W2046706654 created "2016-06-24" @default.
- W2046706654 creator A5027246988 @default.
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- W2046706654 creator A5040379352 @default.
- W2046706654 creator A5044040883 @default.
- W2046706654 creator A5079863689 @default.
- W2046706654 date "2014-07-01" @default.
- W2046706654 modified "2023-10-14" @default.
- W2046706654 title "Gastrin-releasing peptide receptor signaling in the integration of stress and memory" @default.
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