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- W2046707977 abstract "In the 1990 s, liver transplantation for hepatitis B and C virus (HBV and HCV) related-liver diseases was a very controversial issue since recurrent infection of the graft was inevitable. Significant progress has been made in the prophylaxis and treatment of recurrent hepatitis B/C (or HBV/HCV infection) after liver transplantation. In this paper, we propose a mathematical model of ordinary differential equations describing the dynamics of the HBV/HCV and its interaction with both liver and blood cells. A single model is used to describe infection of either virus since the dynamics in-host (infected of the liver) are similar. Analyzing the model, we observe that the system shows either a transcritical or a backward bifurcation. Explicit conditions on the model parameters are given for the backward bifurcation to be present. Consequently, we investigate possible factors that are responsible for HBV/HCV infection and assess control strategies to reduce HBV/HCV reinfection and improve graft survival after liver transplantation." @default.
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- W2046707977 date "2010-04-01" @default.
- W2046707977 modified "2023-09-27" @default.
- W2046707977 title "Influence of backward bifurcation in a model of hepatitis B and C viruses" @default.
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- W2046707977 doi "https://doi.org/10.1016/j.mbs.2010.01.002" @default.
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