Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046746407> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2046746407 endingPage "95" @default.
- W2046746407 startingPage "93" @default.
- W2046746407 abstract "Factors involved in “operational” tolerance in animal models induced by recipient pre-treatment with donor-specific blood transfusion (DSBT) need elucidation. This study examined apoptosis, expression of genes of the Bcl-2 family and of TGF-β1 in isografts, rejecting and tolerant allografts. Adult inbred Dark Agouti (DA) kidneys were transplanted, with immediate nephrectomy of recipient kidneys, to (1) ALLO, inbred Albino Surgery (AS) rats; (2) DSBT ALLO, AS rats who received two DA blood transfusions under cover of cyclosporine prior to transplantation; or (3) ISO, DA rats. Grafts were retrieved on day 1, 3, or 5. Apoptosis was assessed by TUNEL. RNA was extracted and reverse transcribed to cDNA for quantification by real-time PCR, relative to the 18s housekeeping gene. Apoptosis was negligible in ISO while it increased in allograft groups from day 1. On day 5, apoptosis in ALLO (114.0 ± 30.6), involved renal tubular cells and leukocytes compared to DSBT ALLO (9.7 ± 4.0) and ISO (0.9 ± 0.3) involving leukocytes only. On day 1, DSBT ALLO had higher expression of Bax than ALLO or ISO. On day 3, DSBT ALLO and ALLO had higher TGF-β1 mRNA than ISO. On day 5, Bcl-2 expression was significantly decreased (P < .001) in ALLO compared to DSBT ALLO and ISO. Bad and Bid were higher in DSBT ALLO than in ALLO. TGF-β1 was higher in DSBT ALLO compared to ISO. Decreased expression of anti-apoptotic Bcl-2 gene may be implicated in increased apoptosis in rejecting allograft while expression of pro-apoptotic genes may be involved in the establishment of operational tolerance." @default.
- W2046746407 created "2016-06-24" @default.
- W2046746407 creator A5009609035 @default.
- W2046746407 creator A5025015211 @default.
- W2046746407 creator A5032414491 @default.
- W2046746407 creator A5036962985 @default.
- W2046746407 creator A5055244688 @default.
- W2046746407 creator A5058463563 @default.
- W2046746407 creator A5080481502 @default.
- W2046746407 date "2005-01-01" @default.
- W2046746407 modified "2023-09-27" @default.
- W2046746407 title "Apoptosis and the expression of genes of the Bcl-2 family and TGF-β1 in rat renal allografts transplanted after donor-specific blood transfusion" @default.
- W2046746407 cites W1968048857 @default.
- W2046746407 cites W1985018666 @default.
- W2046746407 cites W2022140606 @default.
- W2046746407 cites W2023455887 @default.
- W2046746407 cites W2059422769 @default.
- W2046746407 cites W2072391555 @default.
- W2046746407 cites W2090408621 @default.
- W2046746407 doi "https://doi.org/10.1016/j.transproceed.2004.12.182" @default.
- W2046746407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15808558" @default.
- W2046746407 hasPublicationYear "2005" @default.
- W2046746407 type Work @default.
- W2046746407 sameAs 2046746407 @default.
- W2046746407 citedByCount "0" @default.
- W2046746407 crossrefType "journal-article" @default.
- W2046746407 hasAuthorship W2046746407A5009609035 @default.
- W2046746407 hasAuthorship W2046746407A5025015211 @default.
- W2046746407 hasAuthorship W2046746407A5032414491 @default.
- W2046746407 hasAuthorship W2046746407A5036962985 @default.
- W2046746407 hasAuthorship W2046746407A5055244688 @default.
- W2046746407 hasAuthorship W2046746407A5058463563 @default.
- W2046746407 hasAuthorship W2046746407A5080481502 @default.
- W2046746407 hasConcept C104317684 @default.
- W2046746407 hasConcept C118131993 @default.
- W2046746407 hasConcept C126322002 @default.
- W2046746407 hasConcept C134018914 @default.
- W2046746407 hasConcept C150194340 @default.
- W2046746407 hasConcept C16685009 @default.
- W2046746407 hasConcept C190283241 @default.
- W2046746407 hasConcept C196795494 @default.
- W2046746407 hasConcept C203014093 @default.
- W2046746407 hasConcept C2780014101 @default.
- W2046746407 hasConcept C2911091166 @default.
- W2046746407 hasConcept C33922130 @default.
- W2046746407 hasConcept C54355233 @default.
- W2046746407 hasConcept C71924100 @default.
- W2046746407 hasConcept C86803240 @default.
- W2046746407 hasConceptScore W2046746407C104317684 @default.
- W2046746407 hasConceptScore W2046746407C118131993 @default.
- W2046746407 hasConceptScore W2046746407C126322002 @default.
- W2046746407 hasConceptScore W2046746407C134018914 @default.
- W2046746407 hasConceptScore W2046746407C150194340 @default.
- W2046746407 hasConceptScore W2046746407C16685009 @default.
- W2046746407 hasConceptScore W2046746407C190283241 @default.
- W2046746407 hasConceptScore W2046746407C196795494 @default.
- W2046746407 hasConceptScore W2046746407C203014093 @default.
- W2046746407 hasConceptScore W2046746407C2780014101 @default.
- W2046746407 hasConceptScore W2046746407C2911091166 @default.
- W2046746407 hasConceptScore W2046746407C33922130 @default.
- W2046746407 hasConceptScore W2046746407C54355233 @default.
- W2046746407 hasConceptScore W2046746407C71924100 @default.
- W2046746407 hasConceptScore W2046746407C86803240 @default.
- W2046746407 hasIssue "1" @default.
- W2046746407 hasLocation W20467464071 @default.
- W2046746407 hasLocation W20467464072 @default.
- W2046746407 hasOpenAccess W2046746407 @default.
- W2046746407 hasPrimaryLocation W20467464071 @default.
- W2046746407 hasRelatedWork W1976324993 @default.
- W2046746407 hasRelatedWork W2000944914 @default.
- W2046746407 hasRelatedWork W2004632808 @default.
- W2046746407 hasRelatedWork W2015698633 @default.
- W2046746407 hasRelatedWork W2239138664 @default.
- W2046746407 hasRelatedWork W2354452412 @default.
- W2046746407 hasRelatedWork W2371865725 @default.
- W2046746407 hasRelatedWork W2381162594 @default.
- W2046746407 hasRelatedWork W2441902924 @default.
- W2046746407 hasRelatedWork W655110234 @default.
- W2046746407 hasVolume "37" @default.
- W2046746407 isParatext "false" @default.
- W2046746407 isRetracted "false" @default.
- W2046746407 magId "2046746407" @default.
- W2046746407 workType "article" @default.