Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046753338> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2046753338 endingPage "S181" @default.
- W2046753338 startingPage "S181" @default.
- W2046753338 abstract "The induction of heat shock protein (HSP) 72 by mild electrical stimulation with heat shock (MES + HS), which improves visceral adiposity and insulin resistance in mice, may be beneficial in treating metabolic syndrome (MS) or type 2 diabetes mellitus (T2DM).Using open-label crossover trials, 40 subjects with MS or T2DM were randomly assigned using computer-generated random numbers to 12 weeks of therapeutic MES + HS followed by 12 weeks of no treatment, or vice versa. During the intervention period, physical and biochemical markers were measured.Compared to no treatment, MES + HS treatment was associated with a significant decrease in visceral adiposity (− 7.54 cm2 (− 8.61%), 95% CI − 8.55 to − 6.53 (p = 0.037) in MS, − 19.73 cm2 (− 10.89%), 95% CI − 20.97 to − 18.49 (p = 0.003) in T2DM). Fasting plasma glucose levels were decreased by 3.74 mg/dL (− 5.28%: 95% CI − 4.37 to − 3.09 mg/dL, p = 0.029) in MS and by 14.97 mg/dL (10.40%: 95% CI − 15.79 to 14.15 mg/dL, p < 0.001) in T2DM, and insulin levels were also reduced by 10.39% and 25.93%, respectively. HbA1c levels showed a trend toward reduction (− 0.06%) in MS, and was significantly declined by − 0.43% (95% CI − 0.55 to − 0.31%, p = 0.009) in T2DM. HbA1c level of less than 7.0% was achieved in 52.5% of the MES + HS-treated T2DM patients in contrast to 15% of the non-treated period. Several insulin resistance indices, inflammatory cytokines or adipokines, including C-reactive protein, adiponectin, and tumor necrosis factor-α, were all improved in both groups. In isolated monocytes, HSP72 expression was increased and cytokine expression was reduced following MES + HS treatment. Glucose excursions on meal tolerance test were lower after using MES + HS in T2DM.This combination therapy has beneficial impacts on body composition, metabolic abnormalities, and inflammation in subjects with MS or T2DM. Activation of the heat shock response by MES + HS may provide a novel approach for the treatment of lifestyle-related diseases.Funding for this research was provided by MEXT KAKENHI (Grants-in-Aid for Scientific Research from Ministry of Education, Culture, Sports, Science and Technology, Japan)." @default.
- W2046753338 created "2016-06-24" @default.
- W2046753338 creator A5003658603 @default.
- W2046753338 creator A5016459174 @default.
- W2046753338 creator A5057632330 @default.
- W2046753338 creator A5058103958 @default.
- W2046753338 creator A5086676643 @default.
- W2046753338 date "2007-01-01" @default.
- W2046753338 modified "2023-09-23" @default.
- W2046753338 title "Deletion of Schnurri-2 causes multiple behavioral abnormalities related to psychiatric disorders in mice" @default.
- W2046753338 doi "https://doi.org/10.1016/j.neures.2007.06.790" @default.
- W2046753338 hasPublicationYear "2007" @default.
- W2046753338 type Work @default.
- W2046753338 sameAs 2046753338 @default.
- W2046753338 citedByCount "0" @default.
- W2046753338 crossrefType "journal-article" @default.
- W2046753338 hasAuthorship W2046753338A5003658603 @default.
- W2046753338 hasAuthorship W2046753338A5016459174 @default.
- W2046753338 hasAuthorship W2046753338A5057632330 @default.
- W2046753338 hasAuthorship W2046753338A5058103958 @default.
- W2046753338 hasAuthorship W2046753338A5086676643 @default.
- W2046753338 hasConcept C126322002 @default.
- W2046753338 hasConcept C134018914 @default.
- W2046753338 hasConcept C142724271 @default.
- W2046753338 hasConcept C204787440 @default.
- W2046753338 hasConcept C27081682 @default.
- W2046753338 hasConcept C2777180221 @default.
- W2046753338 hasConcept C2777391703 @default.
- W2046753338 hasConcept C2779306644 @default.
- W2046753338 hasConcept C2780578515 @default.
- W2046753338 hasConcept C2910068830 @default.
- W2046753338 hasConcept C511355011 @default.
- W2046753338 hasConcept C555293320 @default.
- W2046753338 hasConcept C71924100 @default.
- W2046753338 hasConcept C87813604 @default.
- W2046753338 hasConcept C90924648 @default.
- W2046753338 hasConceptScore W2046753338C126322002 @default.
- W2046753338 hasConceptScore W2046753338C134018914 @default.
- W2046753338 hasConceptScore W2046753338C142724271 @default.
- W2046753338 hasConceptScore W2046753338C204787440 @default.
- W2046753338 hasConceptScore W2046753338C27081682 @default.
- W2046753338 hasConceptScore W2046753338C2777180221 @default.
- W2046753338 hasConceptScore W2046753338C2777391703 @default.
- W2046753338 hasConceptScore W2046753338C2779306644 @default.
- W2046753338 hasConceptScore W2046753338C2780578515 @default.
- W2046753338 hasConceptScore W2046753338C2910068830 @default.
- W2046753338 hasConceptScore W2046753338C511355011 @default.
- W2046753338 hasConceptScore W2046753338C555293320 @default.
- W2046753338 hasConceptScore W2046753338C71924100 @default.
- W2046753338 hasConceptScore W2046753338C87813604 @default.
- W2046753338 hasConceptScore W2046753338C90924648 @default.
- W2046753338 hasLocation W20467533381 @default.
- W2046753338 hasOpenAccess W2046753338 @default.
- W2046753338 hasPrimaryLocation W20467533381 @default.
- W2046753338 hasRelatedWork W138803513 @default.
- W2046753338 hasRelatedWork W1979252938 @default.
- W2046753338 hasRelatedWork W1983641721 @default.
- W2046753338 hasRelatedWork W1986132654 @default.
- W2046753338 hasRelatedWork W2010140898 @default.
- W2046753338 hasRelatedWork W2026226896 @default.
- W2046753338 hasRelatedWork W2082140668 @default.
- W2046753338 hasRelatedWork W2169206971 @default.
- W2046753338 hasRelatedWork W2584731720 @default.
- W2046753338 hasRelatedWork W4234612679 @default.
- W2046753338 hasVolume "58" @default.
- W2046753338 isParatext "false" @default.
- W2046753338 isRetracted "false" @default.
- W2046753338 magId "2046753338" @default.
- W2046753338 workType "article" @default.