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• W2046753360 abstract "Aims Solid pseudopapillary neoplasm of the pancreas ( SPN ) is a rare low‐grade malignant neoplasm. To our knowledge, SPN with prominent atypical multinucleated giant tumour cells ( MNGTC s) has not yet been reported. Methods and results We identified four cases of SPN with prominent atypical MNGTC s in a cohort of 62 cases of SPN (6.5%). The MNGTC s contained multiple enlarged, hyperchromatic, irregular nuclei with ample eosinophilic cytoplasm, typically present in the solid area of the tumour. The MNGTC s had an immunohistochemical profile typical of the conventional SPN and were positive for vimentin, β‐catenin, CD 10 and progesterone receptor, but negative for pan‐cytokeratin, chromogranin, synaptophysin, trypsin, Ki‐67 and CD 68 in all four cases. Patients of SPN with prominent MNGTC s were older than those with conventional SPN ( P = 0.01); tumours were discovered incidentally by imaging studies for an unrelated disease in all four cases, and with a female to male ratio of 1:1. The proliferation index (Ki‐67) was <1% in all four cases. None of the three patients for whom information was available developed recurrence during follow‐up of 2.7, 3.8 and 5.0 years. Conclusions The presence of MNGTC s in SPN most probably represents degenerative change of the tumour cells and does not seem to affect the prognosis." @default.
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• W2046753360 date "2012-11-08" @default.
• W2046753360 modified "2023-10-17" @default.
• W2046753360 title "Solid pseudopapillary neoplasm of the pancreas with prominent atypical multinucleated giant tumour cells" @default.
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• W2046753360 doi "https://doi.org/10.1111/his.12023" @default.
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