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• W2046753595 abstract "The West Nile (WN) virus strains isolated in Bangui, Central African Republic (CAR), from patients with hepatitis were analysed comparatively with the prototype WN virus strain and 7 WN strains previously isolated from birds (2 strains), mosquitoes (3 strains) and ticks (2 strains) in CAR. The comparison was based on two techniques: an epitopic analysis by indirect immunofluorescence assay using a panel of 9 monoclonal antibodies to WN virus, and an analysis of HaeIII and TaqI restriction digest profiles of cDNA to infected cell RNA. Similar results were obtained with both techniques: the 3 human strains were found to be identical to each other and identical or very close to mosquito and tick strains, whereas prototype WN virus and bird strains were significantly different from the human strains. As “classical” infections due to WN virus without hepatic involvement were also reported during the period of isolation of the arthropod strains, we concluded that the same virus subtype may have been the cause of different infection patterns. A new definition of the disease spectrum of WN virus, including the possibility of liver involvement, should be established. Clearly, the Egyptian prototype WN virus represents a different topotype. Bird strains also appear to be different from human and arthropod strains, raising the question of their transmissibility and pathogenicity for man, and of the role of birds in the natural cycle of WN virus. Trois souches de virus West Nile (WN) isolées à Bangui (République Centrafricaine), à partir de cas d'hépatite, ont été analysées comparativement à la souche de virus WN de référence et à sept souches isolées dans la même région à partir d'oiseaux (2 souches), de moustiques (3 souches) et de tiques (2 souches). Deux techniques sont utilisées: analyse épitopique par immunofluorescence indirecte à l'aide d'anticorps monoclonaux et analyse des profils de restriction HaeIII et TaqI des ADNc obtenus à partir de l'ARN extrait des cellules infectées. Des résultats similaires ont été obtenus avec les deux techniques: les trois souches humaines sont identiques entre elles et identiques ou très proches des souches moustiques et de tiques, alors que la souche de référence et les souches d'oiseaux diffèrent significativement. Plusieurs cas d'infections ⪡classiques⪢ dues au virus WN ayant été également reportés pendant la période où les souches d'arthropodes ont été isolées, nous concluons que les cas d'hépatites doivent être attribuées à des souches de WN non modifiées génétiquement, ce qui doit nous amener à reconsidérer le spectre pathogénique de ce virus. La référence égyptienne du virus WN représente clairement un topotype différent, ainsi sans doute que les souches isolées d'oiseaux. La question de la transmissibilité des souches d'oiseaux à l'homme et du pouvoir pathogène de ces souches est posée." @default.
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• W2046753595 date "1990-09-01" @default.
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• W2046753595 title "Comparative analysis of west nile virus strains isolated from human and animal hosts using monoclonal antibodies and cDNA restriction digest profiles" @default.
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• W2046753595 doi "https://doi.org/10.1016/0923-2516(90)90085-w" @default.
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