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• W2046754608 abstract "177Lu-AMBA (AMBA = DO3A-CH2CO-G-[4-aminobenzoyl]-QWAVGHLM-NH2) is being developed for the radiotherapeutic treatment of tumors that express the gastrin-releasing peptide receptor (GRP-R). In this study we investigated the fate of the 177hafnium (177Hf) that forms upon the decay of 177Lu while the latter is complexed with AMBA. When decayed solutions of 177Lu-AMBA were analyzed, it was found that 177Hf is retained in the DO3A monoamide chelator, forming a pair of interconverting isomers. We report the synthesis and full characterization of natLu-AMBA and the studies performed to demonstrate its correspondence to radioactive 177Lu-AMBA. We also report the synthesis and characterization of Hf-AMBA and, by NMR studies, show structural analogies between Hf-AMBA, its parent compound Lu-AMBA, and the unmetallated AMBA ligand. In the NMR spectra of both the metallated and unmetallated AMBA ligand, a stacking interaction between the amino benzoyl residue in the linker and a tryptophan in the truncated bombesin [BBN(7-14)-NH2] peptide targeting group was found." @default.
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• W2046754608 date "2009-02-25" @default.
• W2046754608 modified "2023-10-14" @default.
• W2046754608 title "Isolation of a ¹⁷⁷Hf Complex Formed by β-Decay of a ¹⁷⁷Lu-Labeled Radiotherapeutic Compound and NMR Structural Elucidation of the Ligand and its Lu and Hf Complexes" @default.
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• W2046754608 doi "https://doi.org/10.1021/ic802328a" @default.
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