Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046755082> ?p ?o ?g. }
- W2046755082 abstract "In the central nervous system inhibitory neurotransmission is primarily achieved through activation of receptors for gamma-aminobutyric acid (GABA). Three types of GABA receptors have been identified on the basis of their pharmacological and electrophysiological properties. The predominant type, termed GABA(A), and a recently identified GABA(C) type, form ligand-gated chloride channels, whereas GABA(B) receptors activate separate cation channels via G proteins. Based on their homology to nicotinic acetylcholine receptors, GABA(C) receptors are believed to be oligomeric protein complexes composed of five subunits in a pentameric arrangement. To date up to five different GABA(C) receptors subunits have been identified in various species. Recent studies have shed new light on the biological characteristics of GABA(C) receptors, including the chromosomal localization of its subunit genes and resulting links to deseases, the cloning of new splice variants, the identification of GABA(C) receptor-associated proteins, the identification of domains involved in subunit assembly, and finally structure/function studies examining functional consequences of introduced mutations. This review summarizes recent data in view of the molecular structure of GABA(C) receptors and presents new insights into the biological function of this protein in the retina." @default.
- W2046755082 created "2016-06-24" @default.
- W2046755082 creator A5043128836 @default.
- W2046755082 date "2001-01-28" @default.
- W2046755082 modified "2023-09-30" @default.
- W2046755082 title "GABAC Receptors: A Molecular View" @default.
- W2046755082 cites W1482915690 @default.
- W2046755082 cites W1503265626 @default.
- W2046755082 cites W1520935000 @default.
- W2046755082 cites W1577822422 @default.
- W2046755082 cites W1668093331 @default.
- W2046755082 cites W1836652085 @default.
- W2046755082 cites W1853085112 @default.
- W2046755082 cites W1854209661 @default.
- W2046755082 cites W1872667629 @default.
- W2046755082 cites W1970824062 @default.
- W2046755082 cites W1971350452 @default.
- W2046755082 cites W1972288324 @default.
- W2046755082 cites W1978508618 @default.
- W2046755082 cites W1979615495 @default.
- W2046755082 cites W1980425767 @default.
- W2046755082 cites W1981030868 @default.
- W2046755082 cites W1983185397 @default.
- W2046755082 cites W1984272093 @default.
- W2046755082 cites W1984537495 @default.
- W2046755082 cites W1984659561 @default.
- W2046755082 cites W1985682723 @default.
- W2046755082 cites W1985871874 @default.
- W2046755082 cites W1985984620 @default.
- W2046755082 cites W1986315354 @default.
- W2046755082 cites W1988702981 @default.
- W2046755082 cites W1988819966 @default.
- W2046755082 cites W1990015532 @default.
- W2046755082 cites W1992021083 @default.
- W2046755082 cites W1992479059 @default.
- W2046755082 cites W1994288348 @default.
- W2046755082 cites W1996928890 @default.
- W2046755082 cites W1997437840 @default.
- W2046755082 cites W1997605361 @default.
- W2046755082 cites W1997715717 @default.
- W2046755082 cites W1999501054 @default.
- W2046755082 cites W2003563071 @default.
- W2046755082 cites W2008259235 @default.
- W2046755082 cites W2008492335 @default.
- W2046755082 cites W2010123061 @default.
- W2046755082 cites W2012163065 @default.
- W2046755082 cites W2012641954 @default.
- W2046755082 cites W2013253007 @default.
- W2046755082 cites W2013688671 @default.
- W2046755082 cites W2013707622 @default.
- W2046755082 cites W2014774246 @default.
- W2046755082 cites W2014846478 @default.
- W2046755082 cites W2017795547 @default.
- W2046755082 cites W2022382515 @default.
- W2046755082 cites W2023359966 @default.
- W2046755082 cites W2023872774 @default.
- W2046755082 cites W2026053311 @default.
- W2046755082 cites W2026332484 @default.
- W2046755082 cites W2026559607 @default.
- W2046755082 cites W2028092195 @default.
- W2046755082 cites W2029381684 @default.
- W2046755082 cites W2030602458 @default.
- W2046755082 cites W2032482854 @default.
- W2046755082 cites W2045237222 @default.
- W2046755082 cites W2051771420 @default.
- W2046755082 cites W2053046400 @default.
- W2046755082 cites W2053502586 @default.
- W2046755082 cites W2056097178 @default.
- W2046755082 cites W2056145172 @default.
- W2046755082 cites W2056186806 @default.
- W2046755082 cites W2056467356 @default.
- W2046755082 cites W2058349477 @default.
- W2046755082 cites W2058883143 @default.
- W2046755082 cites W2058896100 @default.
- W2046755082 cites W2063996780 @default.
- W2046755082 cites W2069181654 @default.
- W2046755082 cites W2074744180 @default.
- W2046755082 cites W2078615673 @default.
- W2046755082 cites W2079158149 @default.
- W2046755082 cites W2081556250 @default.
- W2046755082 cites W2081716375 @default.
- W2046755082 cites W2087034750 @default.
- W2046755082 cites W2089215633 @default.
- W2046755082 cites W2095947640 @default.
- W2046755082 cites W2111369596 @default.
- W2046755082 cites W2114972922 @default.
- W2046755082 cites W2122283371 @default.
- W2046755082 cites W2123307057 @default.
- W2046755082 cites W2127759683 @default.
- W2046755082 cites W2134766199 @default.
- W2046755082 cites W2144965832 @default.
- W2046755082 cites W2151444391 @default.
- W2046755082 cites W2156652246 @default.
- W2046755082 cites W2167767264 @default.
- W2046755082 cites W2171322161 @default.
- W2046755082 cites W2176076159 @default.
- W2046755082 cites W2243153908 @default.
- W2046755082 cites W2279433062 @default.
- W2046755082 cites W2316746025 @default.
- W2046755082 cites W2328734883 @default.