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- W2046755890 abstract "Significance The selective loss of dopaminergic neurons is characteristic of Parkinson disease (PD). Protein folding stress is a salient feature of PD. This study uncovers a previously undefined function of a major unfolded protein response (UPR) transcription factor (XBP1) in supporting the survival of nigral dopaminergic neurons at basal levels and under pathological conditions. Our results reveal an important role for a canonical UPR pathway in the maintenance of dopaminergic neuron proteostasis, which also could be relevant to understand the selective neuronal vulnerability observed in Parkinson disease." @default.
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- W2046755890 date "2014-04-21" @default.
- W2046755890 modified "2023-10-01" @default.
- W2046755890 title "Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1" @default.
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- W2046755890 doi "https://doi.org/10.1073/pnas.1321845111" @default.
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