Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046758506> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2046758506 endingPage "9" @default.
- W2046758506 startingPage "1" @default.
- W2046758506 abstract "FUT-175 is a synthetic protease inhibitor and an inhibitor of the classical and alternate pathways of complement activation. In human serum, FUT-175 inhibited C3a, C4a and C5a generation induced by heat aggregated IgG, zymosan and Cobra venom factor with IC50 values in the range of 3–43 μM depending on the stimulus and the fragments. To assess in vivo anti-inflammatory activity, inflammatory reactions induced in the skin of rabbits were quantitated by using 125I-albumin extravasation, 51Cr-labelled leukocyte accumulation and 86RbCl accumulation as a measure of hyperemia. Infusion of FUT-175 at 2 mg/kg/h inhibited all three parameters by 50–80% in dermal reactions induced by killed E. coli, zymosan, immune complexes, the reversed Arthus reaction, zymosan activated plasma (ZAP), f-norleu-leu-phe (FNLP) and LTB4. In contrast, the response to endotoxin (0.1 μg) was not effected by FUT-175 treatment. The effect of FUT-175 was comparable to that of local or systemic therapy with indomethacin, but unlike indomethacin, the effect of FUT-175 was not reversed by local PGE2 administration. Furthermore, indomethacin and FUT-175 had additive anti-inflammatory effects. These results suggest that although FUT-175 is a potent inhibitor of C3a, C4a and C5a generation, it has novel and broad anti-inflammatory effects, possibly through actions in addition to complement inhibition as indicated by inhibition of FNLP-, LTB4- and ZAP-induced reactions." @default.
- W2046758506 created "2016-06-24" @default.
- W2046758506 creator A5037489270 @default.
- W2046758506 creator A5041142136 @default.
- W2046758506 creator A5069941343 @default.
- W2046758506 date "1990-01-01" @default.
- W2046758506 modified "2023-09-26" @default.
- W2046758506 title "The effect of FUT-175 (nafamstat mesilate) on C3a, C4a and C5a generation in vitro and inflammatory reactions in vivo" @default.
- W2046758506 cites W1811909808 @default.
- W2046758506 cites W1976791527 @default.
- W2046758506 cites W1983750441 @default.
- W2046758506 cites W2001897468 @default.
- W2046758506 cites W2005015911 @default.
- W2046758506 cites W2006466302 @default.
- W2046758506 cites W2034769239 @default.
- W2046758506 cites W2052333415 @default.
- W2046758506 cites W2058310630 @default.
- W2046758506 cites W2131547680 @default.
- W2046758506 cites W2344995500 @default.
- W2046758506 cites W3035322935 @default.
- W2046758506 cites W4236649809 @default.
- W2046758506 doi "https://doi.org/10.1016/0192-0561(90)90062-r" @default.
- W2046758506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2303313" @default.
- W2046758506 hasPublicationYear "1990" @default.
- W2046758506 type Work @default.
- W2046758506 sameAs 2046758506 @default.
- W2046758506 citedByCount "42" @default.
- W2046758506 countsByYear W20467585062014 @default.
- W2046758506 countsByYear W20467585062018 @default.
- W2046758506 countsByYear W20467585062019 @default.
- W2046758506 crossrefType "journal-article" @default.
- W2046758506 hasAuthorship W2046758506A5037489270 @default.
- W2046758506 hasAuthorship W2046758506A5041142136 @default.
- W2046758506 hasAuthorship W2046758506A5069941343 @default.
- W2046758506 hasConcept C104317684 @default.
- W2046758506 hasConcept C111684460 @default.
- W2046758506 hasConcept C150903083 @default.
- W2046758506 hasConcept C185592680 @default.
- W2046758506 hasConcept C202751555 @default.
- W2046758506 hasConcept C203014093 @default.
- W2046758506 hasConcept C207001950 @default.
- W2046758506 hasConcept C2778870864 @default.
- W2046758506 hasConcept C2779540182 @default.
- W2046758506 hasConcept C55493867 @default.
- W2046758506 hasConcept C71924100 @default.
- W2046758506 hasConcept C86803240 @default.
- W2046758506 hasConcept C8891405 @default.
- W2046758506 hasConcept C90582226 @default.
- W2046758506 hasConcept C90630246 @default.
- W2046758506 hasConcept C98274493 @default.
- W2046758506 hasConceptScore W2046758506C104317684 @default.
- W2046758506 hasConceptScore W2046758506C111684460 @default.
- W2046758506 hasConceptScore W2046758506C150903083 @default.
- W2046758506 hasConceptScore W2046758506C185592680 @default.
- W2046758506 hasConceptScore W2046758506C202751555 @default.
- W2046758506 hasConceptScore W2046758506C203014093 @default.
- W2046758506 hasConceptScore W2046758506C207001950 @default.
- W2046758506 hasConceptScore W2046758506C2778870864 @default.
- W2046758506 hasConceptScore W2046758506C2779540182 @default.
- W2046758506 hasConceptScore W2046758506C55493867 @default.
- W2046758506 hasConceptScore W2046758506C71924100 @default.
- W2046758506 hasConceptScore W2046758506C86803240 @default.
- W2046758506 hasConceptScore W2046758506C8891405 @default.
- W2046758506 hasConceptScore W2046758506C90582226 @default.
- W2046758506 hasConceptScore W2046758506C90630246 @default.
- W2046758506 hasConceptScore W2046758506C98274493 @default.
- W2046758506 hasIssue "1" @default.
- W2046758506 hasLocation W20467585061 @default.
- W2046758506 hasLocation W20467585062 @default.
- W2046758506 hasOpenAccess W2046758506 @default.
- W2046758506 hasPrimaryLocation W20467585061 @default.
- W2046758506 hasRelatedWork W1965032370 @default.
- W2046758506 hasRelatedWork W2010701203 @default.
- W2046758506 hasRelatedWork W2034201329 @default.
- W2046758506 hasRelatedWork W2046758506 @default.
- W2046758506 hasRelatedWork W2057058442 @default.
- W2046758506 hasRelatedWork W2077506189 @default.
- W2046758506 hasRelatedWork W2093621960 @default.
- W2046758506 hasRelatedWork W2394851937 @default.
- W2046758506 hasRelatedWork W2418576129 @default.
- W2046758506 hasRelatedWork W2793625335 @default.
- W2046758506 hasVolume "12" @default.
- W2046758506 isParatext "false" @default.
- W2046758506 isRetracted "false" @default.
- W2046758506 magId "2046758506" @default.
- W2046758506 workType "article" @default.