Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046768162> ?p ?o ?g. }
- W2046768162 endingPage "1588" @default.
- W2046768162 startingPage "1574" @default.
- W2046768162 abstract "Here we develop an integrative computational framework to model biophysical processes involved in viral gene delivery. The model combines reaction-diffusion-advection equations that describe intracellular trafficking with kinetic equations that describe transcription and translation of the exogenous DNA. It relates molecular-level trafficking events to whole-cell distribution of viruses. The approach makes use of the current understanding of cellular processes and data from single-particle single-cell imaging experiments. The model reveals two important parameters that characterize viral transport at the population level, namely, the effective velocity, Veff, and the effective diffusion coefficient, Deff. Veff measures virus’s net movement rate and Deff represents the total dispersion rate. We employ the model to study the influence of microtubule-mediated movements on nuclear targeting and gene expression of adenoviruses of type 2 and type 5 in HeLa and A549 cells. Effects of microtubule organization and the presence of microtubule-destabilizing drugs on viral transport were analyzed and quantified. Model predictions agree well with experimental data available in literature. The paper serves as a guide for future theoretical and experimental efforts to understand viral gene delivery." @default.
- W2046768162 created "2016-06-24" @default.
- W2046768162 creator A5032657131 @default.
- W2046768162 creator A5087180621 @default.
- W2046768162 creator A5091382830 @default.
- W2046768162 date "2005-09-01" @default.
- W2046768162 modified "2023-10-11" @default.
- W2046768162 title "A Model for Intracellular Trafficking of Adenoviral Vectors" @default.
- W2046768162 cites W1480912438 @default.
- W2046768162 cites W1574007450 @default.
- W2046768162 cites W1616824889 @default.
- W2046768162 cites W1967624865 @default.
- W2046768162 cites W1985151525 @default.
- W2046768162 cites W1985675681 @default.
- W2046768162 cites W1985748313 @default.
- W2046768162 cites W1990457708 @default.
- W2046768162 cites W1992322422 @default.
- W2046768162 cites W2000217017 @default.
- W2046768162 cites W2002475826 @default.
- W2046768162 cites W2002652733 @default.
- W2046768162 cites W2010225822 @default.
- W2046768162 cites W2012279551 @default.
- W2046768162 cites W2015171213 @default.
- W2046768162 cites W2019067040 @default.
- W2046768162 cites W2020341083 @default.
- W2046768162 cites W2024450209 @default.
- W2046768162 cites W2027980197 @default.
- W2046768162 cites W2030955277 @default.
- W2046768162 cites W2036105845 @default.
- W2046768162 cites W2040238933 @default.
- W2046768162 cites W2041179764 @default.
- W2046768162 cites W2042145670 @default.
- W2046768162 cites W2066383202 @default.
- W2046768162 cites W2071056869 @default.
- W2046768162 cites W2073273867 @default.
- W2046768162 cites W2077541686 @default.
- W2046768162 cites W2084296558 @default.
- W2046768162 cites W2085434191 @default.
- W2046768162 cites W2111754083 @default.
- W2046768162 cites W2115445026 @default.
- W2046768162 cites W2116422958 @default.
- W2046768162 cites W2118511790 @default.
- W2046768162 cites W2118623016 @default.
- W2046768162 cites W2122806729 @default.
- W2046768162 cites W2135358447 @default.
- W2046768162 cites W2135682000 @default.
- W2046768162 cites W2136303496 @default.
- W2046768162 cites W2145479669 @default.
- W2046768162 cites W2147559180 @default.
- W2046768162 cites W2147890616 @default.
- W2046768162 cites W2151613351 @default.
- W2046768162 cites W2157319245 @default.
- W2046768162 cites W2157815652 @default.
- W2046768162 cites W2158247854 @default.
- W2046768162 cites W2162530599 @default.
- W2046768162 cites W2167746224 @default.
- W2046768162 cites W2168736735 @default.
- W2046768162 cites W2170576230 @default.
- W2046768162 cites W2173136445 @default.
- W2046768162 cites W2177381833 @default.
- W2046768162 cites W4211203651 @default.
- W2046768162 cites W4211216531 @default.
- W2046768162 doi "https://doi.org/10.1529/biophysj.105.059477" @default.
- W2046768162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1366662" @default.
- W2046768162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15980163" @default.
- W2046768162 hasPublicationYear "2005" @default.
- W2046768162 type Work @default.
- W2046768162 sameAs 2046768162 @default.
- W2046768162 citedByCount "66" @default.
- W2046768162 countsByYear W20467681622012 @default.
- W2046768162 countsByYear W20467681622013 @default.
- W2046768162 countsByYear W20467681622014 @default.
- W2046768162 countsByYear W20467681622015 @default.
- W2046768162 countsByYear W20467681622016 @default.
- W2046768162 countsByYear W20467681622017 @default.
- W2046768162 countsByYear W20467681622018 @default.
- W2046768162 countsByYear W20467681622019 @default.
- W2046768162 countsByYear W20467681622021 @default.
- W2046768162 countsByYear W20467681622022 @default.
- W2046768162 crossrefType "journal-article" @default.
- W2046768162 hasAuthorship W2046768162A5032657131 @default.
- W2046768162 hasAuthorship W2046768162A5087180621 @default.
- W2046768162 hasAuthorship W2046768162A5091382830 @default.
- W2046768162 hasBestOaLocation W20467681621 @default.
- W2046768162 hasConcept C104317684 @default.
- W2046768162 hasConcept C105580179 @default.
- W2046768162 hasConcept C121332964 @default.
- W2046768162 hasConcept C12554922 @default.
- W2046768162 hasConcept C135983454 @default.
- W2046768162 hasConcept C144024400 @default.
- W2046768162 hasConcept C149364088 @default.
- W2046768162 hasConcept C149923435 @default.
- W2046768162 hasConcept C20418707 @default.
- W2046768162 hasConcept C2780212709 @default.
- W2046768162 hasConcept C2908647359 @default.
- W2046768162 hasConcept C54009773 @default.
- W2046768162 hasConcept C54355233 @default.
- W2046768162 hasConcept C70721500 @default.