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- W2046768800 abstract "The physiological mechanism of clearance of the mononuclear phagocyte growth factor, colony-stimulating factor 1 (CSF-1), from the circulation of normal mice was investigated by following the fate of a trace amount of i.v. injected 125I-labeled CSF-1. Macrophages selectively cleared CSF-1 by CSF-1 receptor-mediated endocytosis and degraded the growth factor intracellularly. This manner of clearance provides a feedback control mechanism whereby the rate of macrophage production is determined by the number of mature macrophages." @default.
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- W2046768800 date "1987-09-01" @default.
- W2046768800 modified "2023-10-11" @default.
- W2046768800 title "Macrophages specifically regulate the concentration of their own growth factor in the circulation." @default.
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- W2046768800 doi "https://doi.org/10.1073/pnas.84.17.6179" @default.
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