FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046772334> ?p ?o ?g. }

• W2046772334 endingPage "323" @default.
• W2046772334 startingPage "295" @default.
• W2046772334 abstract "Immunoliposomes able to bind specifically to target cells and to release their encapsulated contents upon brief heating were prepared. Monoclonal anti-H2Kk was covalently derivatized with palmitic acid by the method of Huang, A. et al. (Huang, A., Tsao, Y.S., Kennel, S.J. and Huang, L. (1982) Biochim. Biophys. Acta 716, 140–150). The palmitoyl antibody was injected at a controlled rate into a suspension of fused unilamellar dipalmitoylphosphatidylcholine liposomes maintained at a constant temperature. The final protein-to-lipid ratio of the resultant liposomes with incorporated antibody (immunoliposomes) was dependent upon the rate of antibody injection and the lipid concentration. Injection of palmitoyl antibody into a liposome suspension containing 50 mM carboxyfluorescein at 41°C resulted in simultaneous antibody incorporation and entrapment of dye. Immunoliposomes were able to release the entrapped carboxyfluorescein upon heating. The release of dye at temperatures between the pre- and main-transition temperatures of DPPC was abolished by the addition of calf serum (5%). Furthermore, the presence of serum resulted in an increase in the temperature of the maximal release rate and also in the rate of release at that temperature. Retention of antigen-binding capacity was demonstrated by the ability of the immunoliposomes to bind specifically to the target cells. Rapid release of entrapped carboxyfluorescein from immunoliposomes bound to target cells at 4°C was achieved upon brief exposure (less than 3 min) at 41°C. These heat-sensitive immunoliposomes may be useful in enhancing drug delivery to target cells." @default.
• W2046772334 created "2016-06-24" @default.
• W2046772334 creator A5031408853 @default.
• W2046772334 creator A5063672862 @default.
• W2046772334 date "1983-01-01" @default.
• W2046772334 modified "2023-09-23" @default.
• W2046772334 title "Targeting to lymphoid cells of the immune network" @default.
• W2046772334 cites W102933687 @default.
• W2046772334 cites W112859519 @default.
• W2046772334 cites W116736076 @default.
• W2046772334 cites W126114442 @default.
• W2046772334 cites W127444910 @default.
• W2046772334 cites W1426879062 @default.
• W2046772334 cites W143077864 @default.
• W2046772334 cites W1439380746 @default.
• W2046772334 cites W1451272174 @default.
• W2046772334 cites W1481185539 @default.
• W2046772334 cites W1481719524 @default.
• W2046772334 cites W1482371624 @default.
• W2046772334 cites W1482543006 @default.
• W2046772334 cites W1484287322 @default.
• W2046772334 cites W1484629663 @default.
• W2046772334 cites W1485773777 @default.
• W2046772334 cites W1487974349 @default.
• W2046772334 cites W1488332563 @default.
• W2046772334 cites W1490381735 @default.
• W2046772334 cites W1490809158 @default.
• W2046772334 cites W1490954201 @default.
• W2046772334 cites W1495237724 @default.
• W2046772334 cites W1497255946 @default.
• W2046772334 cites W1502366909 @default.
• W2046772334 cites W1504672165 @default.
• W2046772334 cites W1505684651 @default.
• W2046772334 cites W1507938174 @default.
• W2046772334 cites W1508238572 @default.
• W2046772334 cites W1509030499 @default.
• W2046772334 cites W1510788027 @default.
• W2046772334 cites W1517070558 @default.
• W2046772334 cites W1518019316 @default.
• W2046772334 cites W1531835372 @default.
• W2046772334 cites W1535594612 @default.
• W2046772334 cites W1535725176 @default.
• W2046772334 cites W1537562549 @default.
• W2046772334 cites W1537997750 @default.
• W2046772334 cites W1539504944 @default.
• W2046772334 cites W1549359839 @default.
• W2046772334 cites W1549726646 @default.
• W2046772334 cites W1553509057 @default.
• W2046772334 cites W1562895443 @default.
• W2046772334 cites W1563876360 @default.
• W2046772334 cites W1564432735 @default.
• W2046772334 cites W1566766802 @default.
• W2046772334 cites W1569844599 @default.
• W2046772334 cites W1570628434 @default.
• W2046772334 cites W1571722736 @default.
• W2046772334 cites W1573397544 @default.
• W2046772334 cites W1579798455 @default.
• W2046772334 cites W1583883816 @default.
• W2046772334 cites W1584567513 @default.
• W2046772334 cites W1589350140 @default.
• W2046772334 cites W1592141089 @default.
• W2046772334 cites W1604437749 @default.
• W2046772334 cites W1604689671 @default.
• W2046772334 cites W1606271150 @default.
• W2046772334 cites W1637823542 @default.
• W2046772334 cites W1642844412 @default.
• W2046772334 cites W1643282235 @default.
• W2046772334 cites W1663364610 @default.
• W2046772334 cites W1674212647 @default.
• W2046772334 cites W1748467151 @default.
• W2046772334 cites W1803359669 @default.
• W2046772334 cites W1836878077 @default.
• W2046772334 cites W1840837207 @default.
• W2046772334 cites W1855957540 @default.
• W2046772334 cites W1896049145 @default.
• W2046772334 cites W1896110604 @default.
• W2046772334 cites W1900552022 @default.
• W2046772334 cites W1916065677 @default.
• W2046772334 cites W1921301801 @default.
• W2046772334 cites W1938803792 @default.
• W2046772334 cites W1950154886 @default.
• W2046772334 cites W1950166256 @default.
• W2046772334 cites W1963914660 @default.
• W2046772334 cites W1964149427 @default.
• W2046772334 cites W1964453753 @default.
• W2046772334 cites W1965461790 @default.
• W2046772334 cites W1966181511 @default.
• W2046772334 cites W1966263719 @default.
• W2046772334 cites W1968082000 @default.
• W2046772334 cites W1970059208 @default.
• W2046772334 cites W1970695164 @default.
• W2046772334 cites W1971363037 @default.
• W2046772334 cites W1972541960 @default.
• W2046772334 cites W1978575034 @default.
• W2046772334 cites W1980095603 @default.
• W2046772334 cites W1981403541 @default.
• W2046772334 cites W1983256549 @default.
• W2046772334 cites W1984012835 @default.

• next