FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046776008> ?p ?o ?g. }

• W2046776008 endingPage "991" @default.
• W2046776008 startingPage "975" @default.
• W2046776008 abstract "A series of 47, 4-arylthieno[3, 2-d] pyrimidine derivatives was subjected to quantitative structure-antiparkinson activity relationships (QSAR) studies to evaluate the antagonist activity towards both adenosine A1 and adenosine A2A targets in Parkinson's drug discovery. QSAR models were derived with the aid of genetic function approximation (GFA) technique using descriptors to make connections between structural parameters and antiparkinson's activity followed by ADMET analysis and pharmacophore model generation. QSAR model was assessed using a test set of 12 compounds for A1 (r2 pred = 0.961), (q2 = 0.912) and 12 compounds for A2a (r 2 pred = 0.914), (q 2 = 0.781) receptor. The results revealed the significant role of DIPOLE MAG, CHI-V-3-P, WIENER, AREA, SC-2 and PHI-MAG descriptors in the antiparkinson activity of the studied compounds against adenosine A1 and adenosine A2A receptors. Subsequent, ADMET analysis shows 28 compounds can be the better candidates of drug and execution of pharmacophore model, explores the hydrogen bond donor, aromatic ring and hydrophobic groups are the key structural features for the antagonist activity." @default.
• W2046776008 created "2016-06-24" @default.
• W2046776008 creator A5043326298 @default.
• W2046776008 creator A5050425252 @default.
• W2046776008 creator A5062769039 @default.
• W2046776008 date "2010-12-01" @default.
• W2046776008 modified "2023-09-26" @default.
• W2046776008 title "QSAR AND PHARMACOPHORE MODELING OF 4-ARYLTHIENO [3, 2-d] PYRIMIDINE DERIVATIVES AGAINST ADENOSINE RECEPTOR OF PARKINSON'S DISEASE" @default.
• W2046776008 cites W1487233798 @default.
• W2046776008 cites W1500797869 @default.
• W2046776008 cites W1972420008 @default.
• W2046776008 cites W1975740938 @default.
• W2046776008 cites W1977567629 @default.
• W2046776008 cites W1985004315 @default.
• W2046776008 cites W1988824288 @default.
• W2046776008 cites W1992611413 @default.
• W2046776008 cites W1992812982 @default.
• W2046776008 cites W2004350671 @default.
• W2046776008 cites W2016619479 @default.
• W2046776008 cites W2016873483 @default.
• W2046776008 cites W2033108784 @default.
• W2046776008 cites W2033495141 @default.
• W2046776008 cites W2034588648 @default.
• W2046776008 cites W2039736447 @default.
• W2046776008 cites W2040410772 @default.
• W2046776008 cites W2065648608 @default.
• W2046776008 cites W2067643341 @default.
• W2046776008 cites W2073561633 @default.
• W2046776008 cites W2077961825 @default.
• W2046776008 cites W2078799505 @default.
• W2046776008 cites W2083868750 @default.
• W2046776008 cites W2086071289 @default.
• W2046776008 cites W2087661061 @default.
• W2046776008 cites W2096289739 @default.
• W2046776008 cites W2105649494 @default.
• W2046776008 cites W2117360242 @default.
• W2046776008 cites W2118053864 @default.
• W2046776008 cites W2120349335 @default.
• W2046776008 cites W2130343586 @default.
• W2046776008 cites W2136306454 @default.
• W2046776008 cites W2174028107 @default.
• W2046776008 cites W62603772 @default.
• W2046776008 doi "https://doi.org/10.1142/s0219633610006146" @default.
• W2046776008 hasPublicationYear "2010" @default.
• W2046776008 type Work @default.
• W2046776008 sameAs 2046776008 @default.
• W2046776008 citedByCount "10" @default.
• W2046776008 countsByYear W20467760082012 @default.
• W2046776008 countsByYear W20467760082013 @default.
• W2046776008 countsByYear W20467760082016 @default.
• W2046776008 countsByYear W20467760082019 @default.
• W2046776008 countsByYear W20467760082020 @default.
• W2046776008 countsByYear W20467760082021 @default.
• W2046776008 crossrefType "journal-article" @default.
• W2046776008 hasAuthorship W2046776008A5043326298 @default.
• W2046776008 hasAuthorship W2046776008A5050425252 @default.
• W2046776008 hasAuthorship W2046776008A5062769039 @default.
• W2046776008 hasConcept C116569031 @default.
• W2046776008 hasConcept C164126121 @default.
• W2046776008 hasConcept C170493617 @default.
• W2046776008 hasConcept C185592680 @default.
• W2046776008 hasConcept C2776885963 @default.
• W2046776008 hasConcept C2776991684 @default.
• W2046776008 hasConcept C2778938600 @default.
• W2046776008 hasConcept C2779321679 @default.
• W2046776008 hasConcept C55493867 @default.
• W2046776008 hasConcept C56173144 @default.
• W2046776008 hasConcept C67907053 @default.
• W2046776008 hasConcept C71240020 @default.
• W2046776008 hasConceptScore W2046776008C116569031 @default.
• W2046776008 hasConceptScore W2046776008C164126121 @default.
• W2046776008 hasConceptScore W2046776008C170493617 @default.
• W2046776008 hasConceptScore W2046776008C185592680 @default.
• W2046776008 hasConceptScore W2046776008C2776885963 @default.
• W2046776008 hasConceptScore W2046776008C2776991684 @default.
• W2046776008 hasConceptScore W2046776008C2778938600 @default.
• W2046776008 hasConceptScore W2046776008C2779321679 @default.
• W2046776008 hasConceptScore W2046776008C55493867 @default.
• W2046776008 hasConceptScore W2046776008C56173144 @default.
• W2046776008 hasConceptScore W2046776008C67907053 @default.
• W2046776008 hasConceptScore W2046776008C71240020 @default.
• W2046776008 hasIssue "06" @default.
• W2046776008 hasLocation W20467760081 @default.
• W2046776008 hasOpenAccess W2046776008 @default.
• W2046776008 hasPrimaryLocation W20467760081 @default.
• W2046776008 hasRelatedWork W1964407556 @default.
• W2046776008 hasRelatedWork W2013150218 @default.
• W2046776008 hasRelatedWork W2020128067 @default.
• W2046776008 hasRelatedWork W2026082936 @default.
• W2046776008 hasRelatedWork W2046776008 @default.
• W2046776008 hasRelatedWork W2064280680 @default.
• W2046776008 hasRelatedWork W2064487101 @default.
• W2046776008 hasRelatedWork W2285901211 @default.
• W2046776008 hasRelatedWork W2888047260 @default.
• W2046776008 hasRelatedWork W2085813174 @default.
• W2046776008 hasVolume "09" @default.
• W2046776008 isParatext "false" @default.
• W2046776008 isRetracted "false" @default.

• next