FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046787429> ?p ?o ?g. }

• W2046787429 abstract "In this study, we assessed the effects of the acute (a single injection) and repeated (once daily injections for 21 days) administration of the atypical antipsychotic drug clozapine (1.5, 5, or 15 mg/kg i.p.) and the typical antipsychotic drug haloperidol (0.15, 0.5, and 1.5 mg/kg, i.p.) on hippocampal partial seizures generated by low-frequency electrical stimulation in male Wistar rats. The seizure threshold and severity were determined by measuring the pulse number threshold (PNT) and the primary afterdischarge duration (ADD), respectively. A single injection of either 5 or 15 mg/kg of clozapine significantly decreased the PNT and significantly increased the primary ADD, indicating a proconvulsant action. The repeated administration of clozapine (1.5, 5, or 15 mg/kg, i.p.) produced dose-dependent, proconvulsant effects by significantly decreasing the PNT and by significantly increasing the primary ADD. In contrast to clozapine, the acute administration of haloperidol did not significantly alter the PNT or the primary ADD. The repeated administration of haloperidol (0.5 and 1.5 mg/kg, i.p.), unlike clozapine, significantly decreased the primary ADD, but did not alter the PNT. Overall, clozapine produces a greater proconvulsant action than haloperidol in an animal model of hippocampal seizures." @default.
• W2046787429 created "2016-06-24" @default.
• W2046787429 creator A5011209888 @default.
• W2046787429 creator A5024651931 @default.
• W2046787429 creator A5030390485 @default.
• W2046787429 creator A5053805669 @default.
• W2046787429 date "1998-07-01" @default.
• W2046787429 modified "2023-09-26" @default.
• W2046787429 title "Acute and chronic administration of clozapine produces greater proconvulsant actions than haloperidol on focal hippocampal seizures in freely moving rats" @default.
• W2046787429 cites W1967466077 @default.
• W2046787429 cites W1973825043 @default.
• W2046787429 cites W1981199626 @default.
• W2046787429 cites W1987405898 @default.
• W2046787429 cites W1992744313 @default.
• W2046787429 cites W1994617447 @default.
• W2046787429 cites W1996340934 @default.
• W2046787429 cites W1997153721 @default.
• W2046787429 cites W2004534434 @default.
• W2046787429 cites W2005088930 @default.
• W2046787429 cites W2008586442 @default.
• W2046787429 cites W2012012802 @default.
• W2046787429 cites W2019233381 @default.
• W2046787429 cites W2021189652 @default.
• W2046787429 cites W2025348471 @default.
• W2046787429 cites W2031786430 @default.
• W2046787429 cites W2034957480 @default.
• W2046787429 cites W2035375883 @default.
• W2046787429 cites W2037483796 @default.
• W2046787429 cites W2041482818 @default.
• W2046787429 cites W2046346017 @default.
• W2046787429 cites W2047154863 @default.
• W2046787429 cites W2049594669 @default.
• W2046787429 cites W2050985632 @default.
• W2046787429 cites W2052235325 @default.
• W2046787429 cites W2055083785 @default.
• W2046787429 cites W2057216398 @default.
• W2046787429 cites W2058980289 @default.
• W2046787429 cites W2060167838 @default.
• W2046787429 cites W2062272731 @default.
• W2046787429 cites W2063783661 @default.
• W2046787429 cites W2072281981 @default.
• W2046787429 cites W2074753317 @default.
• W2046787429 cites W2077038577 @default.
• W2046787429 cites W2080591188 @default.
• W2046787429 cites W2081478166 @default.
• W2046787429 cites W2082490117 @default.
• W2046787429 cites W2083109085 @default.
• W2046787429 cites W2083596046 @default.
• W2046787429 cites W2085360366 @default.
• W2046787429 cites W2086504486 @default.
• W2046787429 cites W2087154822 @default.
• W2046787429 cites W2088187643 @default.
• W2046787429 cites W2092341955 @default.
• W2046787429 cites W2103946141 @default.
• W2046787429 cites W2115737094 @default.
• W2046787429 cites W2150117416 @default.
• W2046787429 cites W2162905199 @default.
• W2046787429 cites W2213034002 @default.
• W2046787429 cites W2418302419 @default.
• W2046787429 cites W245699743 @default.
• W2046787429 doi "https://doi.org/10.1002/(sici)1098-2396(199807)29:3<272::aid-syn10>3.0.co;2-v" @default.
• W2046787429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9635898" @default.
• W2046787429 hasPublicationYear "1998" @default.
• W2046787429 type Work @default.
• W2046787429 sameAs 2046787429 @default.
• W2046787429 citedByCount "13" @default.
• W2046787429 countsByYear W20467874292014 @default.
• W2046787429 countsByYear W20467874292015 @default.
• W2046787429 countsByYear W20467874292018 @default.
• W2046787429 countsByYear W20467874292021 @default.
• W2046787429 crossrefType "journal-article" @default.
• W2046787429 hasAuthorship W2046787429A5011209888 @default.
• W2046787429 hasAuthorship W2046787429A5024651931 @default.
• W2046787429 hasAuthorship W2046787429A5030390485 @default.
• W2046787429 hasAuthorship W2046787429A5053805669 @default.
• W2046787429 hasConcept C118552586 @default.
• W2046787429 hasConcept C126322002 @default.
• W2046787429 hasConcept C148762608 @default.
• W2046787429 hasConcept C24998067 @default.
• W2046787429 hasConcept C2775858608 @default.
• W2046787429 hasConcept C2775870346 @default.
• W2046787429 hasConcept C2776412080 @default.
• W2046787429 hasConcept C2776921671 @default.
• W2046787429 hasConcept C2778186239 @default.
• W2046787429 hasConcept C2778460930 @default.
• W2046787429 hasConcept C2780494398 @default.
• W2046787429 hasConcept C2780864610 @default.
• W2046787429 hasConcept C2780948584 @default.
• W2046787429 hasConcept C42219234 @default.
• W2046787429 hasConcept C513476851 @default.
• W2046787429 hasConcept C71924100 @default.
• W2046787429 hasConcept C98274493 @default.
• W2046787429 hasConceptScore W2046787429C118552586 @default.
• W2046787429 hasConceptScore W2046787429C126322002 @default.
• W2046787429 hasConceptScore W2046787429C148762608 @default.
• W2046787429 hasConceptScore W2046787429C24998067 @default.
• W2046787429 hasConceptScore W2046787429C2775858608 @default.
• W2046787429 hasConceptScore W2046787429C2775870346 @default.
• W2046787429 hasConceptScore W2046787429C2776412080 @default.
• W2046787429 hasConceptScore W2046787429C2776921671 @default.

• next