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- W2046802040 abstract "SYNOPSIS. A comparison of the effects upon trypsin‐dispersed chick liver cell cultures of a virulent (Jones' Barn) and a non‐pathogenic (Lahore) strain of Trichomonas gallinae revealed significant differences in behavior of the parasites in cell cultures and in the response of such cultures. The virulent strain multiplies faster in nutrient medium in the presence of cell cultures; stimulates great activity of the macrophages; is not handled effectively by these phagocytes in which it can multiply causing their ultimate destruction; is found significantly more often within the cytoplasm of the liver epithelial and fibroblast‐like cells; causes very much more profound degenerative changes in all the cells, both invaded and non‐invaded; and suppresses effectively the division rate of the fibroblast‐like cells. On the other hand, the nonpathogenic strain multiplies at a lower rate in the presence of cell cultures; stimulates less activity of the macrophages; is handled readily by these phagocytes in which it multiplies only very rarely, if ever; is found seldom within the liver epithelial and fibroblast‐like cells; causes far less degeneration of all the cell culture elements; and suppresses significantly less the dlvision rate of the fibroblast‐like cells. At the end of a 20–24 hour period typically only a few living cells are left in cultures exposed even to attenuated isolates of the virulent strain, whereas those inoculated with the mild one do not show much degeneration even after 28 hours. The effects upon the cell cultures of cell‐free filtrates of actively growing trichomonad cultures are relatively minor, but the changes caused by the filtrates of cultures of Jones' Barn strain appear to be more extensive than those caused by similar filtrates of Lahore strain." @default.
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- W2046802040 date "1964-11-01" @default.
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- W2046802040 title "The Behavior and Pathogenicity of Two Strains of<i>Trichomonas gallinae</i>in Cell Cultures*" @default.
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- W2046802040 doi "https://doi.org/10.1111/j.1550-7408.1964.tb01779.x" @default.
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