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• W2046804510 abstract "RationaleClara cell 10-kd protein (CC10), a member of the secretoglobin family, is secreted constitutively at high levels by Clara cells in the bronchi and nasal epithelial cells. It exhibits several anti-inflammatory and immunomodulatory effects. We have shown CC10 expression was significantly down-regulated in nasal polyp (NP) tissues. However, its expression in chronic rhinosinusitis (CRS) without NPs and it regulation in CRS is unclear.MethodsSurgical samples were investigated by means of quantitative RT-PCR for evaluation of CC10 mRNA expression, and the presence and location of CC10 positive cells were analyzed by means of immunohistochemistry. Furthermore, nasal explant culture and quantitative RT-PCR techniques were used to investigate the effect of various cytokines on CC10 mRNA production in sinonasal mucosa.ResultsCompared with control inferior turbinate tissues, CC10 mRNA and protein expression was significantly down-regulated not only in NP tissues but also in sinus mucosal tissues from CRS without NPs. When comparing polyp tissues and nonpolyp sinus tissues, no significant difference was found. Dexamethasone, TNF-α, IL-4, and IL-13 could inhibit CC10 mRNA expression, while the INF-γ could up-regulate CC10 mRNA expression.ConclusionsCC10 expression is similarly inhibited in CRS with and without NPs and regulated by the local cytokine-milieu. RationaleClara cell 10-kd protein (CC10), a member of the secretoglobin family, is secreted constitutively at high levels by Clara cells in the bronchi and nasal epithelial cells. It exhibits several anti-inflammatory and immunomodulatory effects. We have shown CC10 expression was significantly down-regulated in nasal polyp (NP) tissues. However, its expression in chronic rhinosinusitis (CRS) without NPs and it regulation in CRS is unclear. Clara cell 10-kd protein (CC10), a member of the secretoglobin family, is secreted constitutively at high levels by Clara cells in the bronchi and nasal epithelial cells. It exhibits several anti-inflammatory and immunomodulatory effects. We have shown CC10 expression was significantly down-regulated in nasal polyp (NP) tissues. However, its expression in chronic rhinosinusitis (CRS) without NPs and it regulation in CRS is unclear. MethodsSurgical samples were investigated by means of quantitative RT-PCR for evaluation of CC10 mRNA expression, and the presence and location of CC10 positive cells were analyzed by means of immunohistochemistry. Furthermore, nasal explant culture and quantitative RT-PCR techniques were used to investigate the effect of various cytokines on CC10 mRNA production in sinonasal mucosa. Surgical samples were investigated by means of quantitative RT-PCR for evaluation of CC10 mRNA expression, and the presence and location of CC10 positive cells were analyzed by means of immunohistochemistry. Furthermore, nasal explant culture and quantitative RT-PCR techniques were used to investigate the effect of various cytokines on CC10 mRNA production in sinonasal mucosa. ResultsCompared with control inferior turbinate tissues, CC10 mRNA and protein expression was significantly down-regulated not only in NP tissues but also in sinus mucosal tissues from CRS without NPs. When comparing polyp tissues and nonpolyp sinus tissues, no significant difference was found. Dexamethasone, TNF-α, IL-4, and IL-13 could inhibit CC10 mRNA expression, while the INF-γ could up-regulate CC10 mRNA expression. Compared with control inferior turbinate tissues, CC10 mRNA and protein expression was significantly down-regulated not only in NP tissues but also in sinus mucosal tissues from CRS without NPs. When comparing polyp tissues and nonpolyp sinus tissues, no significant difference was found. Dexamethasone, TNF-α, IL-4, and IL-13 could inhibit CC10 mRNA expression, while the INF-γ could up-regulate CC10 mRNA expression. ConclusionsCC10 expression is similarly inhibited in CRS with and without NPs and regulated by the local cytokine-milieu. CC10 expression is similarly inhibited in CRS with and without NPs and regulated by the local cytokine-milieu." @default.
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• W2046804510 date "2008-02-01" @default.
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• W2046804510 title "CC10 Expression and its Cytokine-driven Regulation in Chronic Rhinosinusitis" @default.
• W2046804510 doi "https://doi.org/10.1016/j.jaci.2007.12.287" @default.
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