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- W2046806571 abstract "Novel influenza A (H1N1) is a flu virus of swine origin that first caused human illness in Mexico and the United States in March and April of 2009. By June of 2009, all 50 states had reported cases of novel H1N1 infection.1 On June 11, 2009, the World Health Organization (WHO) elevated the worldwide pandemic alert to Phase 6, indicating wide spread human to human transmission and recognition that H1N1 spread had reached pandemic proportions.2 The WHO has recommended that antiviral agents, including oseltamivir, be used in the treatment of suspected or confirmed cases of H1N1 influenza in at risk patients, such as the very young, elderly, pregnant woman, immunosuppressed patients, and those with co-morbid conditions.Oseltamivir is the preferred therapy for those who present with severe or progressive illness.3 With increased utilization of antivirals, including oseltamivir, previously undescribed drug-drug interactions and adverse events may emerge. We describe two recent cases of patients tolerating long-term sotalol who developed marked QT interval prolongation and required resuscitation from polymorphic ventricular tachycardia (torsades de pointes, TdP) during oseltamivir treatment for H1N1 influenza." @default.
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- W2046806571 date "2010-10-01" @default.
- W2046806571 modified "2023-09-24" @default.
- W2046806571 title "Sotalol-induced torsades de pointes precipitated during treatment with oseltamivir for H1N1 influenza" @default.
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- W2046806571 doi "https://doi.org/10.1016/j.hrthm.2010.07.025" @default.
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