Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046807890> ?p ?o ?g. }
- W2046807890 abstract "Abstract Background With the development of experimental techniques and bioinformatics, the quantity of data available from protein-protein interactions (PPIs) is increasing exponentially. Functional modules can be identified from protein interaction networks. It follows that the investigation of functional modules will generate a better understanding of cellular organization, processes, and functions. However, experimental PPI data are still limited, and no modularity analysis of PPIs in pathogens has been published to date. Results In this study, we predict and analyze the functional modules of E. coli O157:H7 systemically by integrating several bioinformatics methods. After evaluation, most of the predicted modules are found to be biologically significant and functionally homogeneous. Six pathogenicity-related modules were discovered and analyzed, including novel modules. These modules provided new information on the pathogenicity of O157:H7. The modularity of cellular function and cooperativity between modules are also discussed. Moreover, modularity analysis of O157:H7 can provide possible candidates for biological pathway extension and clues for discovering new pathways of cross-talk. Conclusions This article provides the first modularity analysis of a pathogen and sheds new light on the study of pathogens and cellular processes. Our study also provides a strategy for applying modularity analysis to any sequenced organism." @default.
- W2046807890 created "2016-06-24" @default.
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- W2046807890 date "2011-12-01" @default.
- W2046807890 modified "2023-10-17" @default.
- W2046807890 title "Modularity analysis based on predicted protein-protein interactions provides new insights into pathogenicity and cellular process of Escherichia coli O157:H7" @default.
- W2046807890 cites W1514916393 @default.
- W2046807890 cites W1626287517 @default.
- W2046807890 cites W1644749979 @default.
- W2046807890 cites W1783384641 @default.
- W2046807890 cites W1908782445 @default.
- W2046807890 cites W1953884398 @default.
- W2046807890 cites W1964601681 @default.
- W2046807890 cites W1966597734 @default.
- W2046807890 cites W1968196536 @default.
- W2046807890 cites W1969381663 @default.
- W2046807890 cites W1970350442 @default.
- W2046807890 cites W1979814868 @default.
- W2046807890 cites W1980762570 @default.
- W2046807890 cites W1982267716 @default.
- W2046807890 cites W1982888190 @default.
- W2046807890 cites W1991071802 @default.
- W2046807890 cites W1994801829 @default.
- W2046807890 cites W1995932087 @default.
- W2046807890 cites W1998777645 @default.
- W2046807890 cites W1999234724 @default.
- W2046807890 cites W1999640107 @default.
- W2046807890 cites W2003436933 @default.
- W2046807890 cites W2003915689 @default.
- W2046807890 cites W2006495385 @default.
- W2046807890 cites W2008620264 @default.
- W2046807890 cites W2010372231 @default.
- W2046807890 cites W2011997699 @default.
- W2046807890 cites W2018045523 @default.
- W2046807890 cites W2018696676 @default.
- W2046807890 cites W2026362078 @default.
- W2046807890 cites W2036058988 @default.
- W2046807890 cites W2040117880 @default.
- W2046807890 cites W2040676542 @default.
- W2046807890 cites W2042613054 @default.
- W2046807890 cites W2045131140 @default.
- W2046807890 cites W2045765967 @default.
- W2046807890 cites W2047693963 @default.
- W2046807890 cites W2050721857 @default.
- W2046807890 cites W2051119646 @default.
- W2046807890 cites W2061615066 @default.
- W2046807890 cites W2070067221 @default.
- W2046807890 cites W2075046123 @default.
- W2046807890 cites W2080922074 @default.
- W2046807890 cites W2081208119 @default.
- W2046807890 cites W2081743225 @default.
- W2046807890 cites W2091448229 @default.
- W2046807890 cites W2099836442 @default.
- W2046807890 cites W2102319161 @default.
- W2046807890 cites W2102957091 @default.
- W2046807890 cites W2103017472 @default.
- W2046807890 cites W2106119591 @default.
- W2046807890 cites W2107340752 @default.
- W2046807890 cites W2109793735 @default.
- W2046807890 cites W2112820661 @default.
- W2046807890 cites W2113654464 @default.
- W2046807890 cites W2116117181 @default.
- W2046807890 cites W2119566573 @default.
- W2046807890 cites W2124166542 @default.
- W2046807890 cites W2127146104 @default.
- W2046807890 cites W2128276810 @default.
- W2046807890 cites W2130832525 @default.
- W2046807890 cites W2130900937 @default.
- W2046807890 cites W2133290100 @default.
- W2046807890 cites W2140000393 @default.
- W2046807890 cites W2146538795 @default.
- W2046807890 cites W2151296292 @default.
- W2046807890 cites W2157116022 @default.
- W2046807890 cites W2157346087 @default.
- W2046807890 cites W2158430061 @default.
- W2046807890 cites W2159386862 @default.
- W2046807890 cites W2161746138 @default.
- W2046807890 cites W2162749433 @default.
- W2046807890 cites W2168753903 @default.
- W2046807890 cites W4256647194 @default.
- W2046807890 cites W4300852524 @default.
- W2046807890 doi "https://doi.org/10.1186/1742-4682-8-47" @default.
- W2046807890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3275473" @default.
- W2046807890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22188601" @default.
- W2046807890 hasPublicationYear "2011" @default.
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