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• W2046808384 abstract "The induction of sarcomas following the subcutaneous implantation of cured methyl methacrylate in mice (Laskin, Robinson, and Weinmann, Proc. Soc. Exptl. Biol. Med., 87:329, 1954) has aroused considerable interest in its carcinogenic potential. The palate of the hamster offered a suitable site to study the effects of long-term exposure of an oral mucous membrane to this material in the form of an acrylic resin appliance. Twenty-two male Golden Syrian hamsters, approximately 4 months of age, were used. Appliances were-constructed for 12 animals, while 10 were retained as controls. The appliances were underextended, to enable the animals to tolerate them for a long period. Alginate impressions were obtained in adapted, small-gauge, steel-mesh impression trays and were poured in stone. The impressions included the areas to be covered by the appliance-namely, the hard palate anterior to the first molars and the triangles of soft tissue between the molars and' the central incisors. The finished appliance consisted of a self-cured acrylic resin base and a pair of imbedded wires and silk sutures (3-0 black silk) to be used for retention in the posterior and anterior areas, respectively. One of the posterior ligatures (0.014-inch, 18-8 stainless-steel wire) was passed palato-buccally through the interproximal space between the maxillary first and second molars and was secured to the other wire. The anterior sutures were passedthrough the upper lip as high in the mucobuccal fold as possible and tied lightly on the surface of the skin. The animals adjusted' quickly to the appliances, and all animals survived the experimental period. Although the anterior ligatures ruptured in six of the animals, the retention of the appliances was not impaired. No discernible weight loss occurred, as compared with normal controls. Half the animals were sacrificed after 3 months, while the remainder were retained for 9 months from the beginning of the experiment. Clinical and microscopic examination revealed no abnormal changes in the palate of the experimental animals. The absence of tissue changes for 9 months indicates the unlikelihood that self-cured acrylic resin possesses carcinogenic properties for this mucous membrane. Since the animals maintained their normal weights, it appears that no interference with mastication occurred and that an underextended control appliance could be worn by the animal indefinitely. Modifications, such as extension of the various flanges, could be employed to produce traumatic occlusion or chronic ulceration of soft tissue and other trauma. Such techniques may be of value in the study of experimental periodontal disease and of the role of chronic irritation in carcinogenesis. The potential of this appliance as a vehicle for the testing of drugs against oral mucosa might also be explored." @default.
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• W2046808384 date "1962-03-01" @default.
• W2046808384 modified "2023-09-25" @default.
• W2046808384 title "Effects of an Acrylic Resin Appliance on the Hamster Palate" @default.
• W2046808384 doi "https://doi.org/10.1177/00220345620410022501" @default.
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