Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046809265> ?p ?o ?g. }
- W2046809265 endingPage "221" @default.
- W2046809265 startingPage "211" @default.
- W2046809265 abstract "The aim of the present study is to investigate the potential therapeutic action of RvCSd, an oriental herbal mixture, in an experimental model of rheumatoid arthritis (RA). DBA/1J mice were immunized with type II collagen. After a second collagen immunization, mice were treated with RvCSd or methotrexate (MTX) orally once a day for 35 days, and the incidence, clinical score, and joint histopathology were evaluated. The inflammatory response cytokines and cartilage protection effect were determined by measuring the levels in the joints and sera. The Th1/Th2-mediated auto-reactive response was evaluated by determining the proliferative response and cytokines of drained spleen cells stimulated with type II collagen. RvCSd treatment significantly reduced the incidence and severity of CIA, markedly abrogating joint swelling, synovial hyperplasia, and cartilage destruction. RvCSd significantly inhibited the production of interleukin (IL)-1β, tumor necrosis factor (TNF)-α and IL-6, IL-2, interferon (IFN)-γ, and matrix metalloproteinases (MMP)-1 and up-regulated anti-inflammatory cytokines IL-4, IL-10, and metalloproteinase (TIMP)-1 in mice with CIA. In conclusion, RvCSd has therapeutic effects exerted through inhibition of inflammatory and Th1 responses, regulation of MMP/TIMP, and induction of regulatory T cells in CIA; these effects make RvCSd an outstanding candidate for use as an immune suppressive and cartilage protective medicine in RA patients." @default.
- W2046809265 created "2016-06-24" @default.
- W2046809265 creator A5003019223 @default.
- W2046809265 creator A5008734316 @default.
- W2046809265 creator A5022852733 @default.
- W2046809265 creator A5071444571 @default.
- W2046809265 creator A5077421037 @default.
- W2046809265 creator A5091643338 @default.
- W2046809265 date "2009-01-01" @default.
- W2046809265 modified "2023-10-16" @default.
- W2046809265 title "The Efficacy and Mechanism Action of RvCSd, a New Herbal Agent, on Immune Suppression and Cartilage Protection in a Mouse Model of Rheumatoid Arthritis" @default.
- W2046809265 cites W1555634619 @default.
- W2046809265 cites W1661347229 @default.
- W2046809265 cites W1967297296 @default.
- W2046809265 cites W1967315269 @default.
- W2046809265 cites W1967727186 @default.
- W2046809265 cites W1969498482 @default.
- W2046809265 cites W1977040840 @default.
- W2046809265 cites W1980480613 @default.
- W2046809265 cites W1983081844 @default.
- W2046809265 cites W1988721729 @default.
- W2046809265 cites W2006474879 @default.
- W2046809265 cites W2017770388 @default.
- W2046809265 cites W2031092466 @default.
- W2046809265 cites W2035862262 @default.
- W2046809265 cites W2038172095 @default.
- W2046809265 cites W2038377232 @default.
- W2046809265 cites W2041562979 @default.
- W2046809265 cites W2041831186 @default.
- W2046809265 cites W2052596695 @default.
- W2046809265 cites W2072037483 @default.
- W2046809265 cites W2083748640 @default.
- W2046809265 cites W2108364576 @default.
- W2046809265 cites W2108611253 @default.
- W2046809265 cites W2109658199 @default.
- W2046809265 cites W2132017943 @default.
- W2046809265 cites W2140669143 @default.
- W2046809265 cites W2142497985 @default.
- W2046809265 cites W2147316411 @default.
- W2046809265 cites W2149026148 @default.
- W2046809265 cites W2158433114 @default.
- W2046809265 cites W2158811477 @default.
- W2046809265 cites W2160578379 @default.
- W2046809265 cites W2330496155 @default.
- W2046809265 cites W2974627606 @default.
- W2046809265 cites W4232537459 @default.
- W2046809265 cites W4236183098 @default.
- W2046809265 cites W4244216823 @default.
- W2046809265 cites W4377247951 @default.
- W2046809265 cites W2462132580 @default.
- W2046809265 doi "https://doi.org/10.1254/jphs.08256fp" @default.
- W2046809265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19234364" @default.
- W2046809265 hasPublicationYear "2009" @default.
- W2046809265 type Work @default.
- W2046809265 sameAs 2046809265 @default.
- W2046809265 citedByCount "16" @default.
- W2046809265 countsByYear W20468092652012 @default.
- W2046809265 countsByYear W20468092652013 @default.
- W2046809265 countsByYear W20468092652014 @default.
- W2046809265 countsByYear W20468092652015 @default.
- W2046809265 countsByYear W20468092652016 @default.
- W2046809265 countsByYear W20468092652017 @default.
- W2046809265 countsByYear W20468092652018 @default.
- W2046809265 countsByYear W20468092652021 @default.
- W2046809265 countsByYear W20468092652023 @default.
- W2046809265 crossrefType "journal-article" @default.
- W2046809265 hasAuthorship W2046809265A5003019223 @default.
- W2046809265 hasAuthorship W2046809265A5008734316 @default.
- W2046809265 hasAuthorship W2046809265A5022852733 @default.
- W2046809265 hasAuthorship W2046809265A5071444571 @default.
- W2046809265 hasAuthorship W2046809265A5077421037 @default.
- W2046809265 hasAuthorship W2046809265A5091643338 @default.
- W2046809265 hasBestOaLocation W20468092651 @default.
- W2046809265 hasConcept C105702510 @default.
- W2046809265 hasConcept C109523444 @default.
- W2046809265 hasConcept C126322002 @default.
- W2046809265 hasConcept C142724271 @default.
- W2046809265 hasConcept C164027704 @default.
- W2046809265 hasConcept C17991360 @default.
- W2046809265 hasConcept C203014093 @default.
- W2046809265 hasConcept C204787440 @default.
- W2046809265 hasConcept C2776164576 @default.
- W2046809265 hasConcept C2776914184 @default.
- W2046809265 hasConcept C2777077863 @default.
- W2046809265 hasConcept C2777575956 @default.
- W2046809265 hasConcept C2778690821 @default.
- W2046809265 hasConcept C2780550940 @default.
- W2046809265 hasConcept C2780931953 @default.
- W2046809265 hasConcept C2781013607 @default.
- W2046809265 hasConcept C2781059491 @default.
- W2046809265 hasConcept C71924100 @default.
- W2046809265 hasConcept C74172505 @default.
- W2046809265 hasConcept C8891405 @default.
- W2046809265 hasConcept C98274493 @default.
- W2046809265 hasConceptScore W2046809265C105702510 @default.
- W2046809265 hasConceptScore W2046809265C109523444 @default.
- W2046809265 hasConceptScore W2046809265C126322002 @default.
- W2046809265 hasConceptScore W2046809265C142724271 @default.