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- W2046809382 endingPage "e32264" @default.
- W2046809382 startingPage "e32264" @default.
- W2046809382 abstract "K+ channels play a vital homeostatic role in cells and abnormal activity of these channels can dramatically alter cell function and survival, suggesting that they might be attractive drug targets in pathogenic organisms. Pathogenic protozoa lead to diseases such as malaria, leishmaniasis, trypanosomiasis and dysentery that are responsible for millions of deaths each year worldwide. The genomes of many protozoan parasites have recently been sequenced, allowing rational design of targeted therapies. We analyzed the genomes of pathogenic protozoa and show the existence within them of genes encoding putative homologues of K+ channels. These protozoan K+ channel homologues represent novel targets for anti-parasitic drugs. Differences in the sequences and diversity of human and parasite proteins may allow pathogen-specific targeting of these K+ channel homologues." @default.
- W2046809382 created "2016-06-24" @default.
- W2046809382 creator A5019399622 @default.
- W2046809382 creator A5083648229 @default.
- W2046809382 date "2012-02-21" @default.
- W2046809382 modified "2023-10-11" @default.
- W2046809382 title "Identification of Putative Potassium Channel Homologues in Pathogenic Protozoa" @default.
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