Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046809488> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2046809488 abstract "Based on studies presented here and other published experiments performed with surviving tissue preparations, with transfected cells and with cells that constitutively express the human angiotensin I converting enzyme ACE and B2 receptors, we concluded the following: ACE inhibitors and other endogenous peptides that react with the active site of ACE potentiate the effect of bradykinin and its ACE resistant peptide congeners on the B2 receptor. They also resensitize receptors which had been desensitized by the agonist. ACE and bradykinin receptors have to be sterically close, possibly forming a heterodimer, for the ACE inhibitors to induce an allosteric modification on the receptor. When ACE inhibitors augment bradykinin effects, they reduce the phosphorylation of the B2 receptor. The primary actions of bradykinin on the receptor are not affected by protein kinase C or phosphatase inhibitors, but the potentiation of bradykinin or the resensitization of the receptor by ACE inhibitors are abolished by the same inhibitors. The results with protein kinase C and phosphatase inhibitors indicate that another intermediate protein may be involved in the processes of signaling induced by ACE inhibitors, and that ACE inhibitors affect the signal transduction pathway triggered by bradykinin on the B2 receptor." @default.
- W2046809488 created "2016-06-24" @default.
- W2046809488 creator A5043911586 @default.
- W2046809488 creator A5079743521 @default.
- W2046809488 date "2001-01-06" @default.
- W2046809488 modified "2023-10-10" @default.
- W2046809488 title "Kinins, Receptors, Kininases and Inhibitors Where Did They Lead Us?" @default.
- W2046809488 cites W1502335790 @default.
- W2046809488 cites W180946569 @default.
- W2046809488 cites W1968425665 @default.
- W2046809488 cites W1982771615 @default.
- W2046809488 cites W1983924502 @default.
- W2046809488 cites W1986284688 @default.
- W2046809488 cites W1991234816 @default.
- W2046809488 cites W2003024065 @default.
- W2046809488 cites W2041747627 @default.
- W2046809488 cites W2042789374 @default.
- W2046809488 cites W2044055632 @default.
- W2046809488 cites W2052751062 @default.
- W2046809488 cites W2053758372 @default.
- W2046809488 cites W2062131389 @default.
- W2046809488 cites W2067744221 @default.
- W2046809488 cites W2072639812 @default.
- W2046809488 cites W2077301263 @default.
- W2046809488 cites W2094387426 @default.
- W2046809488 cites W2101314260 @default.
- W2046809488 cites W2105695083 @default.
- W2046809488 cites W2134593344 @default.
- W2046809488 cites W2136792665 @default.
- W2046809488 cites W943225328 @default.
- W2046809488 doi "https://doi.org/10.1515/bc.2001.007" @default.
- W2046809488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11258670" @default.
- W2046809488 hasPublicationYear "2001" @default.
- W2046809488 type Work @default.
- W2046809488 sameAs 2046809488 @default.
- W2046809488 citedByCount "46" @default.
- W2046809488 countsByYear W20468094882012 @default.
- W2046809488 countsByYear W20468094882015 @default.
- W2046809488 countsByYear W20468094882017 @default.
- W2046809488 countsByYear W20468094882018 @default.
- W2046809488 countsByYear W20468094882019 @default.
- W2046809488 countsByYear W20468094882021 @default.
- W2046809488 crossrefType "journal-article" @default.
- W2046809488 hasAuthorship W2046809488A5043911586 @default.
- W2046809488 hasAuthorship W2046809488A5079743521 @default.
- W2046809488 hasConcept C11960822 @default.
- W2046809488 hasConcept C153939273 @default.
- W2046809488 hasConcept C166342909 @default.
- W2046809488 hasConcept C170493617 @default.
- W2046809488 hasConcept C178666793 @default.
- W2046809488 hasConcept C185592680 @default.
- W2046809488 hasConcept C2778938600 @default.
- W2046809488 hasConcept C2779591629 @default.
- W2046809488 hasConcept C55493867 @default.
- W2046809488 hasConcept C62478195 @default.
- W2046809488 hasConcept C86803240 @default.
- W2046809488 hasConcept C98274493 @default.
- W2046809488 hasConceptScore W2046809488C11960822 @default.
- W2046809488 hasConceptScore W2046809488C153939273 @default.
- W2046809488 hasConceptScore W2046809488C166342909 @default.
- W2046809488 hasConceptScore W2046809488C170493617 @default.
- W2046809488 hasConceptScore W2046809488C178666793 @default.
- W2046809488 hasConceptScore W2046809488C185592680 @default.
- W2046809488 hasConceptScore W2046809488C2778938600 @default.
- W2046809488 hasConceptScore W2046809488C2779591629 @default.
- W2046809488 hasConceptScore W2046809488C55493867 @default.
- W2046809488 hasConceptScore W2046809488C62478195 @default.
- W2046809488 hasConceptScore W2046809488C86803240 @default.
- W2046809488 hasConceptScore W2046809488C98274493 @default.
- W2046809488 hasLocation W20468094881 @default.
- W2046809488 hasLocation W20468094882 @default.
- W2046809488 hasOpenAccess W2046809488 @default.
- W2046809488 hasPrimaryLocation W20468094881 @default.
- W2046809488 hasRelatedWork W1505408758 @default.
- W2046809488 hasRelatedWork W1559798894 @default.
- W2046809488 hasRelatedWork W1764686129 @default.
- W2046809488 hasRelatedWork W1923208982 @default.
- W2046809488 hasRelatedWork W1971501265 @default.
- W2046809488 hasRelatedWork W1982771615 @default.
- W2046809488 hasRelatedWork W1983924502 @default.
- W2046809488 hasRelatedWork W2028145191 @default.
- W2046809488 hasRelatedWork W2030547459 @default.
- W2046809488 hasRelatedWork W2041747627 @default.
- W2046809488 hasRelatedWork W2049579566 @default.
- W2046809488 hasRelatedWork W2094387426 @default.
- W2046809488 hasRelatedWork W2101314260 @default.
- W2046809488 hasRelatedWork W2123696429 @default.
- W2046809488 hasRelatedWork W2134593344 @default.
- W2046809488 hasRelatedWork W2161399617 @default.
- W2046809488 hasRelatedWork W2161832913 @default.
- W2046809488 hasRelatedWork W2262763314 @default.
- W2046809488 hasRelatedWork W2039842308 @default.
- W2046809488 hasRelatedWork W2154322752 @default.
- W2046809488 isParatext "false" @default.
- W2046809488 isRetracted "false" @default.
- W2046809488 magId "2046809488" @default.
- W2046809488 workType "article" @default.