FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046832010> ?p ?o ?g. }

• W2046832010 endingPage "911" @default.
• W2046832010 startingPage "901" @default.
• W2046832010 abstract "SUMMARY Mutants of norpA, encoding phospholipase Cβ (PLCβ), and itpr, encoding inositol (1,4,5)-trisphosphate receptor(IP3R), both attenuate response to diuretic peptides of Drosophila melanogaster renal (Malpighian) tubules. Intact tubules from norpA mutants severely reduced diuresis stimulated by the principal cell- and stellate cell-specific neuropeptides, CAP2b and Drosophila leucokinin (Drosokinin), respectively, suggesting a role for PLCβ in both these cell types. Measurement of IP3production in wild-type tubules and in Drosokinin-receptor-transfected S2 cells stimulated with CAP2b and Drosokinin, respectively, confirmed that both neuropeptides elevate IP3 levels. In itpr hypomorphs, basal IP3 levels are lower,although CAP2b-stimulated IP3 levels are not significantly reduced compared with wild type. However,CAP2b-stimulated fluid transport is significantly reduced in itpr alleles. Rescue of the itpr90B.0 allele with wild-type itpr restores CAP2b-stimulated fluid transport levels to wild type. Drosokinin-stimulated fluid transport is also reduced in homozygous and heteroallelic itpr mutants. Measurements of cytosolic calcium levels in intact tubules of wild-type and itpr mutants using targeted expression of the calcium reporter,aequorin, show that mutations in itpr attenuated both CAP2b- and Drosokinin-stimulated calcium responses. The reductions in calcium signals are associated with corresponding reductions in fluid transport rates. Thus, we describe a role for norpA and itpr in renal epithelia and show that both CAP2b and Drosokinin are PLCβ-dependent, IP3-mobilising neuropeptides in Drosophila. IP3R contributes to the calcium signalling cascades initiated by these peptides in both principal and stellate cells." @default.
• W2046832010 created "2016-06-24" @default.
• W2046832010 creator A5023834954 @default.
• W2046832010 creator A5031614544 @default.
• W2046832010 creator A5054509738 @default.
• W2046832010 creator A5072772917 @default.
• W2046832010 creator A5081615109 @default.
• W2046832010 creator A5082419301 @default.
• W2046832010 date "2003-03-01" @default.
• W2046832010 modified "2023-10-03" @default.
• W2046832010 title "<i>norpA</i>and<i>itpr</i>mutants reveal roles for phospholipase C and inositol (1,4,5)- trisphosphate receptor in<i>Drosophila melanogaster</i>renal function" @default.
• W2046832010 cites W1490293082 @default.
• W2046832010 cites W1537970310 @default.
• W2046832010 cites W1543899213 @default.
• W2046832010 cites W1584196799 @default.
• W2046832010 cites W1828818916 @default.
• W2046832010 cites W1844539864 @default.
• W2046832010 cites W1861977700 @default.
• W2046832010 cites W1900367239 @default.
• W2046832010 cites W1902896093 @default.
• W2046832010 cites W1974528573 @default.
• W2046832010 cites W1975421593 @default.
• W2046832010 cites W1986037404 @default.
• W2046832010 cites W1994251246 @default.
• W2046832010 cites W1997508709 @default.
• W2046832010 cites W2002971054 @default.
• W2046832010 cites W2007354719 @default.
• W2046832010 cites W2018554801 @default.
• W2046832010 cites W2020699084 @default.
• W2046832010 cites W2034517366 @default.
• W2046832010 cites W2044222466 @default.
• W2046832010 cites W2081169868 @default.
• W2046832010 cites W2108364746 @default.
• W2046832010 cites W2149673819 @default.
• W2046832010 cites W2150691484 @default.
• W2046832010 cites W2161194691 @default.
• W2046832010 cites W2162253314 @default.
• W2046832010 cites W2240467006 @default.
• W2046832010 cites W2240723666 @default.
• W2046832010 cites W2268896030 @default.
• W2046832010 doi "https://doi.org/10.1242/jeb.00189" @default.
• W2046832010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12547945" @default.
• W2046832010 hasPublicationYear "2003" @default.
• W2046832010 type Work @default.
• W2046832010 sameAs 2046832010 @default.
• W2046832010 citedByCount "50" @default.
• W2046832010 countsByYear W20468320102012 @default.
• W2046832010 countsByYear W20468320102013 @default.
• W2046832010 countsByYear W20468320102014 @default.
• W2046832010 countsByYear W20468320102017 @default.
• W2046832010 countsByYear W20468320102018 @default.
• W2046832010 countsByYear W20468320102019 @default.
• W2046832010 countsByYear W20468320102021 @default.
• W2046832010 countsByYear W20468320102022 @default.
• W2046832010 crossrefType "journal-article" @default.
• W2046832010 hasAuthorship W2046832010A5023834954 @default.
• W2046832010 hasAuthorship W2046832010A5031614544 @default.
• W2046832010 hasAuthorship W2046832010A5054509738 @default.
• W2046832010 hasAuthorship W2046832010A5072772917 @default.
• W2046832010 hasAuthorship W2046832010A5081615109 @default.
• W2046832010 hasAuthorship W2046832010A5082419301 @default.
• W2046832010 hasBestOaLocation W20468320101 @default.
• W2046832010 hasConcept C104317684 @default.
• W2046832010 hasConcept C126322002 @default.
• W2046832010 hasConcept C134018914 @default.
• W2046832010 hasConcept C143065580 @default.
• W2046832010 hasConcept C150149183 @default.
• W2046832010 hasConcept C152624196 @default.
• W2046832010 hasConcept C170493617 @default.
• W2046832010 hasConcept C173758957 @default.
• W2046832010 hasConcept C207583985 @default.
• W2046832010 hasConcept C22145727 @default.
• W2046832010 hasConcept C2777427919 @default.
• W2046832010 hasConcept C2778597717 @default.
• W2046832010 hasConcept C2780104201 @default.
• W2046832010 hasConcept C519063684 @default.
• W2046832010 hasConcept C55493867 @default.
• W2046832010 hasConcept C59822182 @default.
• W2046832010 hasConcept C62478195 @default.
• W2046832010 hasConcept C71924100 @default.
• W2046832010 hasConcept C79879829 @default.
• W2046832010 hasConcept C80933277 @default.
• W2046832010 hasConcept C86803240 @default.
• W2046832010 hasConcept C95444343 @default.
• W2046832010 hasConceptScore W2046832010C104317684 @default.
• W2046832010 hasConceptScore W2046832010C126322002 @default.
• W2046832010 hasConceptScore W2046832010C134018914 @default.
• W2046832010 hasConceptScore W2046832010C143065580 @default.
• W2046832010 hasConceptScore W2046832010C150149183 @default.
• W2046832010 hasConceptScore W2046832010C152624196 @default.
• W2046832010 hasConceptScore W2046832010C170493617 @default.
• W2046832010 hasConceptScore W2046832010C173758957 @default.
• W2046832010 hasConceptScore W2046832010C207583985 @default.
• W2046832010 hasConceptScore W2046832010C22145727 @default.
• W2046832010 hasConceptScore W2046832010C2777427919 @default.
• W2046832010 hasConceptScore W2046832010C2778597717 @default.
• W2046832010 hasConceptScore W2046832010C2780104201 @default.
• W2046832010 hasConceptScore W2046832010C519063684 @default.

• next