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• W2046834643 abstract "A promising strategy for cancer immunotherapy is to disrupt key pathways regulating immune tolerance, such as cytotoxic T lymphocyte-associated protein 4 (CTLA-4). However, the determinants of response to anti-CTLA-4 mAb treatment remain incompletely understood. In murine models, anti-CTLA-4 mAbs alone fail to induce effective immune responses to poorly immunogenic tumors but are successful when combined with additional interventions, including local ionizing radiation (IR) therapy. We employed an established model based on control of a mouse carcinoma cell line to study endogenous tumor-infiltrating CD8+ T lymphocytes (TILs) following treatment with the anti-CTLA-4 mAb 9H10. Alone, 9H10 monotherapy reversed the arrest of TILs with carcinoma cells in vivo. In contrast, the combination of 9H10 and IR restored MHC class I-dependent arrest. After implantation, the carcinoma cells had reduced expression of retinoic acid early inducible-1 (RAE-1), a ligand for natural killer cell group 2D (NKG2D) receptor. We found that RAE-1 expression was induced by IR in vivo and that anti-NKG2D mAb blocked the TIL arrest induced by IR/9H10 combination therapy. These results demonstrate that anti-CTLA-4 mAb therapy induces motility of TIL and that NKG2D ligation offsets this effect to enhance TILs arrest and antitumor activity." @default.
• W2046834643 created "2016-06-24" @default.
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• W2046834643 date "2012-10-01" @default.
• W2046834643 modified "2023-10-12" @default.
• W2046834643 title "Suppressing T cell motility induced by anti–CTLA-4 monotherapy improves antitumor effects" @default.
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• W2046834643 cites W1513449775 @default.
• W2046834643 cites W1524125877 @default.
• W2046834643 cites W1583925965 @default.
• W2046834643 cites W1595098530 @default.
• W2046834643 cites W1603913234 @default.
• W2046834643 cites W1775761483 @default.
• W2046834643 cites W1825402033 @default.
• W2046834643 cites W1964934179 @default.
• W2046834643 cites W1966577330 @default.
• W2046834643 cites W1967889234 @default.
• W2046834643 cites W1969003615 @default.
• W2046834643 cites W1969464492 @default.
• W2046834643 cites W1971422121 @default.
• W2046834643 cites W1972406353 @default.
• W2046834643 cites W1979878166 @default.
• W2046834643 cites W1982889687 @default.
• W2046834643 cites W1984072908 @default.
• W2046834643 cites W1985092313 @default.
• W2046834643 cites W1985322739 @default.
• W2046834643 cites W1987240796 @default.
• W2046834643 cites W1995935389 @default.
• W2046834643 cites W1999341606 @default.
• W2046834643 cites W2009487870 @default.
• W2046834643 cites W2022609922 @default.
• W2046834643 cites W2024957425 @default.
• W2046834643 cites W2025167652 @default.
• W2046834643 cites W2044451873 @default.
• W2046834643 cites W2047488334 @default.
• W2046834643 cites W2052859476 @default.
• W2046834643 cites W2055175265 @default.
• W2046834643 cites W2057801890 @default.
• W2046834643 cites W2061071534 @default.
• W2046834643 cites W2062188387 @default.
• W2046834643 cites W2067301876 @default.
• W2046834643 cites W2073343574 @default.
• W2046834643 cites W2076706365 @default.
• W2046834643 cites W2080442133 @default.
• W2046834643 cites W2082983645 @default.
• W2046834643 cites W2085332498 @default.
• W2046834643 cites W2085991037 @default.
• W2046834643 cites W2087482409 @default.
• W2046834643 cites W2093424661 @default.
• W2046834643 cites W2094366129 @default.
• W2046834643 cites W2096269010 @default.
• W2046834643 cites W2097593754 @default.
• W2046834643 cites W2107393704 @default.
• W2046834643 cites W2108604103 @default.
• W2046834643 cites W2113173540 @default.
• W2046834643 cites W2116141068 @default.
• W2046834643 cites W2116169737 @default.
• W2046834643 cites W2116813877 @default.
• W2046834643 cites W2117878645 @default.
• W2046834643 cites W2119088830 @default.
• W2046834643 cites W2120338564 @default.
• W2046834643 cites W2122715090 @default.
• W2046834643 cites W2124836729 @default.
• W2046834643 cites W2125395855 @default.
• W2046834643 cites W2125891998 @default.
• W2046834643 cites W2127733313 @default.
• W2046834643 cites W2130211103 @default.
• W2046834643 cites W2131874142 @default.
• W2046834643 cites W2133739473 @default.
• W2046834643 cites W2134362149 @default.
• W2046834643 cites W2134738680 @default.
• W2046834643 cites W2137240305 @default.
• W2046834643 cites W2137869737 @default.
• W2046834643 cites W2138853264 @default.
• W2046834643 cites W2141102490 @default.
• W2046834643 cites W2142300779 @default.
• W2046834643 cites W2143645620 @default.
• W2046834643 cites W2149244682 @default.
• W2046834643 cites W2149928606 @default.
• W2046834643 cites W21553284 @default.
• W2046834643 cites W2160613616 @default.
• W2046834643 cites W2162540156 @default.
• W2046834643 cites W2162744515 @default.
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• W2046834643 doi "https://doi.org/10.1172/jci61931" @default.
• W2046834643 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3461908" @default.
• W2046834643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22945631" @default.
• W2046834643 hasPublicationYear "2012" @default.

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