FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046838199> ?p ?o ?g. }

• W2046838199 endingPage "11" @default.
• W2046838199 startingPage "1" @default.
• W2046838199 abstract "Trinucleotide repeat expansion disorders (TREDs) are a group of dominantly inherited neurological diseases caused by the expansion of unstable repeats in specific regions of the associated genes. Expansion of CAG repeat tracts in translated regions of the respective genes results in polyglutamine- (polyQ-) rich proteins that form intracellular aggregates that affect numerous cellular activities. Recent evidence suggests the involvement of an RNA toxicity component in polyQ expansion disorders, thus increasing the complexity of the pathogenic processes. Neurodegeneration, accompanied by reactive gliosis and astrocytosis is the common feature of most TREDs, which may suggest involvement of inflammation in pathogenesis. Indeed, a number of immune response markers have been observed in the blood and CNS of patients and mouse models, and the activation of these markers was even observed in the premanifest stage of the disease. Although inflammation is not an initiating factor of TREDs, growing evidence indicates that inflammatory responses involving astrocytes, microglia, and the peripheral immune system may contribute to disease progression. Herein, we review the involvement of the immune system in the pathogenesis of triplet repeat expansion diseases, with particular emphasis on polyglutamine disorders. We also present various therapeutic approaches targeting the dysregulated inflammation pathways in these diseases." @default.
• W2046838199 created "2016-06-24" @default.
• W2046838199 creator A5023779562 @default.
• W2046838199 creator A5039950251 @default.
• W2046838199 creator A5067430256 @default.
• W2046838199 date "2015-01-01" @default.
• W2046838199 modified "2023-10-14" @default.
• W2046838199 title "The Role of the Immune System in Triplet Repeat Expansion Diseases" @default.
• W2046838199 cites W1480365384 @default.
• W2046838199 cites W1485896673 @default.
• W2046838199 cites W1519690546 @default.
• W2046838199 cites W1531415074 @default.
• W2046838199 cites W1565788467 @default.
• W2046838199 cites W1604791477 @default.
• W2046838199 cites W1722844298 @default.
• W2046838199 cites W1965341424 @default.
• W2046838199 cites W1966151464 @default.
• W2046838199 cites W1968440938 @default.
• W2046838199 cites W1969072247 @default.
• W2046838199 cites W1969947853 @default.
• W2046838199 cites W1975464681 @default.
• W2046838199 cites W1977381117 @default.
• W2046838199 cites W1977724573 @default.
• W2046838199 cites W1978262065 @default.
• W2046838199 cites W1979140326 @default.
• W2046838199 cites W1982170400 @default.
• W2046838199 cites W1984434130 @default.
• W2046838199 cites W1988110501 @default.
• W2046838199 cites W1990286385 @default.
• W2046838199 cites W1992898455 @default.
• W2046838199 cites W1994285647 @default.
• W2046838199 cites W1994630501 @default.
• W2046838199 cites W1997626531 @default.
• W2046838199 cites W1998855617 @default.
• W2046838199 cites W2001683794 @default.
• W2046838199 cites W2003551942 @default.
• W2046838199 cites W2007024808 @default.
• W2046838199 cites W2009110155 @default.
• W2046838199 cites W2013029120 @default.
• W2046838199 cites W2014586239 @default.
• W2046838199 cites W2015925750 @default.
• W2046838199 cites W2016281944 @default.
• W2046838199 cites W2016721233 @default.
• W2046838199 cites W2018013642 @default.
• W2046838199 cites W2019444314 @default.
• W2046838199 cites W2020117714 @default.
• W2046838199 cites W2021549542 @default.
• W2046838199 cites W2023541056 @default.
• W2046838199 cites W2025009643 @default.
• W2046838199 cites W2025681964 @default.
• W2046838199 cites W2026775975 @default.
• W2046838199 cites W2029440153 @default.
• W2046838199 cites W2030307679 @default.
• W2046838199 cites W2039436205 @default.
• W2046838199 cites W2040271470 @default.
• W2046838199 cites W2041513855 @default.
• W2046838199 cites W2043339602 @default.
• W2046838199 cites W2044030703 @default.
• W2046838199 cites W2046984168 @default.
• W2046838199 cites W2051666368 @default.
• W2046838199 cites W2054588014 @default.
• W2046838199 cites W2055467844 @default.
• W2046838199 cites W2057739264 @default.
• W2046838199 cites W2061932385 @default.
• W2046838199 cites W2062528826 @default.
• W2046838199 cites W2063858768 @default.
• W2046838199 cites W2063874562 @default.
• W2046838199 cites W2064492312 @default.
• W2046838199 cites W2066639470 @default.
• W2046838199 cites W2072262246 @default.
• W2046838199 cites W2072396956 @default.
• W2046838199 cites W2073012734 @default.
• W2046838199 cites W2074172901 @default.
• W2046838199 cites W2076361525 @default.
• W2046838199 cites W2077164928 @default.
• W2046838199 cites W2079172704 @default.
• W2046838199 cites W2079250951 @default.
• W2046838199 cites W2080160135 @default.
• W2046838199 cites W2081635886 @default.
• W2046838199 cites W2082277808 @default.
• W2046838199 cites W2082313673 @default.
• W2046838199 cites W2083076780 @default.
• W2046838199 cites W2086364629 @default.
• W2046838199 cites W2087161646 @default.
• W2046838199 cites W2090804892 @default.
• W2046838199 cites W2092480387 @default.
• W2046838199 cites W2097704427 @default.
• W2046838199 cites W2099040590 @default.
• W2046838199 cites W2099673459 @default.
• W2046838199 cites W2100275934 @default.
• W2046838199 cites W2102671926 @default.
• W2046838199 cites W2105291133 @default.
• W2046838199 cites W2107369774 @default.
• W2046838199 cites W2108092527 @default.
• W2046838199 cites W2108570063 @default.
• W2046838199 cites W2109299139 @default.
• W2046838199 cites W2111464898 @default.
• W2046838199 cites W2113242124 @default.

• next