FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046870180> ?p ?o ?g. }

• W2046870180 endingPage "676" @default.
• W2046870180 startingPage "669" @default.
• W2046870180 abstract "Abstract Objective Insulin resistance (IR) and obesity are common features of the polycystic ovary syndrome (PCOS). Insulin-sensitizing agents have been shown to improve both reproductive and metabolic aspects of PCOS, but it remains unclear whether it is also beneficial in lean patients without pre-treatment IR. The aim of this study was to determine the influence of metformin on the clinical and biochemical parameters of PCOS irrespective of the presence of basal obesity and IR. Design The effect of 6 months of metformin treatment was prospectively assessed in 188 PCOS patients, divided into three groups according to body mass index (BMI; lean: BMI<25 kg/m 2 , overweight: BMI 25–29 kg/m 2 , and obese: BMI≥30 kg/m 2 ). Outcome parameters, which were also assessed in 102 healthy controls, included body weight, homeostasis model assessment for IR (HOMA-IR), fasting glucose and insulin levels, area under the curve of insulin response (AUCI), hyperandrogenism, and menstrual irregularities. Results In comparison with the respective BMI-appropriate control groups, only obese but not lean and overweight PCOS patients showed differences in fasting insulin and HOMA-IR. Metformin therapy significantly improved all outcome parameters except fasting glucose levels. Subgroup analyses revealed that in the group of lean PCOS patients without pre-treatment IR, metformin significantly improved HOMA-IR (1.7±1.0 vs 1.1±0.7 μmol/l×mmol/l 2 ) and fasting insulin levels (7.7±4.2 vs 5.4±3.9 mU/l), in addition to testosterone levels (2.6±0.9 vs 1.8±0.7 nmol/l), anovulation rate (2.3 vs 59.5%), and acne (31.8 vs 11.6%; all P <0.017). In the overweight and obese PCOS groups, metformin also showed the expected beneficial effects. Conclusion Metformin improves parameters of IR, hyperandrogenemia, anovulation, and acne in PCOS irrespective of pre-treatment IR or obesity." @default.
• W2046870180 created "2016-06-24" @default.
• W2046870180 creator A5003021652 @default.
• W2046870180 creator A5009448137 @default.
• W2046870180 creator A5013643593 @default.
• W2046870180 creator A5016706958 @default.
• W2046870180 creator A5026996845 @default.
• W2046870180 creator A5029264958 @default.
• W2046870180 creator A5048053034 @default.
• W2046870180 creator A5051007333 @default.
• W2046870180 creator A5052434013 @default.
• W2046870180 creator A5062682729 @default.
• W2046870180 creator A5069932110 @default.
• W2046870180 date "2007-11-01" @default.
• W2046870180 modified "2023-10-15" @default.
• W2046870180 title "Metformin improves polycystic ovary syndrome symptoms irrespective of pre-treatment insulin resistance" @default.
• W2046870180 cites W1970467884 @default.
• W2046870180 cites W1973722085 @default.
• W2046870180 cites W1994494139 @default.
• W2046870180 cites W1996806039 @default.
• W2046870180 cites W2016671924 @default.
• W2046870180 cites W2017738726 @default.
• W2046870180 cites W2029538247 @default.
• W2046870180 cites W2033667814 @default.
• W2046870180 cites W2037628009 @default.
• W2046870180 cites W2043939998 @default.
• W2046870180 cites W2044970382 @default.
• W2046870180 cites W2055744696 @default.
• W2046870180 cites W2076169228 @default.
• W2046870180 cites W2096887626 @default.
• W2046870180 cites W2098558143 @default.
• W2046870180 cites W2113943040 @default.
• W2046870180 cites W2123436272 @default.
• W2046870180 cites W2123925343 @default.
• W2046870180 cites W2126438731 @default.
• W2046870180 cites W2133184757 @default.
• W2046870180 cites W2141438722 @default.
• W2046870180 cites W2158017547 @default.
• W2046870180 cites W2170954272 @default.
• W2046870180 cites W2171439516 @default.
• W2046870180 cites W2406682105 @default.
• W2046870180 cites W4233393676 @default.
• W2046870180 cites W4244659853 @default.
• W2046870180 cites W4247364756 @default.
• W2046870180 cites W4248497310 @default.
• W2046870180 cites W4249124461 @default.
• W2046870180 cites W4255865234 @default.
• W2046870180 cites W4256605237 @default.
• W2046870180 doi "https://doi.org/10.1530/eje-07-0294" @default.
• W2046870180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17984248" @default.
• W2046870180 hasPublicationYear "2007" @default.
• W2046870180 type Work @default.
• W2046870180 sameAs 2046870180 @default.
• W2046870180 citedByCount "90" @default.
• W2046870180 countsByYear W20468701802012 @default.
• W2046870180 countsByYear W20468701802013 @default.
• W2046870180 countsByYear W20468701802014 @default.
• W2046870180 countsByYear W20468701802015 @default.
• W2046870180 countsByYear W20468701802016 @default.
• W2046870180 countsByYear W20468701802017 @default.
• W2046870180 countsByYear W20468701802018 @default.
• W2046870180 countsByYear W20468701802019 @default.
• W2046870180 countsByYear W20468701802020 @default.
• W2046870180 countsByYear W20468701802021 @default.
• W2046870180 countsByYear W20468701802022 @default.
• W2046870180 countsByYear W20468701802023 @default.
• W2046870180 crossrefType "journal-article" @default.
• W2046870180 hasAuthorship W2046870180A5003021652 @default.
• W2046870180 hasAuthorship W2046870180A5009448137 @default.
• W2046870180 hasAuthorship W2046870180A5013643593 @default.
• W2046870180 hasAuthorship W2046870180A5016706958 @default.
• W2046870180 hasAuthorship W2046870180A5026996845 @default.
• W2046870180 hasAuthorship W2046870180A5029264958 @default.
• W2046870180 hasAuthorship W2046870180A5048053034 @default.
• W2046870180 hasAuthorship W2046870180A5051007333 @default.
• W2046870180 hasAuthorship W2046870180A5052434013 @default.
• W2046870180 hasAuthorship W2046870180A5062682729 @default.
• W2046870180 hasAuthorship W2046870180A5069932110 @default.
• W2046870180 hasBestOaLocation W20468701801 @default.
• W2046870180 hasConcept C126322002 @default.
• W2046870180 hasConcept C134018914 @default.
• W2046870180 hasConcept C2777391703 @default.
• W2046870180 hasConcept C2778024521 @default.
• W2046870180 hasConcept C2779306644 @default.
• W2046870180 hasConcept C2780186808 @default.
• W2046870180 hasConcept C2780221984 @default.
• W2046870180 hasConcept C2780323712 @default.
• W2046870180 hasConcept C2780586474 @default.
• W2046870180 hasConcept C3018442814 @default.
• W2046870180 hasConcept C511355011 @default.
• W2046870180 hasConcept C71924100 @default.
• W2046870180 hasConceptScore W2046870180C126322002 @default.
• W2046870180 hasConceptScore W2046870180C134018914 @default.
• W2046870180 hasConceptScore W2046870180C2777391703 @default.
• W2046870180 hasConceptScore W2046870180C2778024521 @default.
• W2046870180 hasConceptScore W2046870180C2779306644 @default.
• W2046870180 hasConceptScore W2046870180C2780186808 @default.
• W2046870180 hasConceptScore W2046870180C2780221984 @default.

• next