FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046871776> ?p ?o ?g. }

• W2046871776 endingPage "1668" @default.
• W2046871776 startingPage "1662" @default.
• W2046871776 abstract "Introduction Radiation recall (RR) is an acute inflammatory reaction confined to previously irradiated areas after the administration of various pharmacological agents. A diverse range of chemotherapies has been associated with RR but no case series with targeted therapies (TT) has been reported. Patients and methods From a database of 346,933 cancer patients ⩾18 years treated at Institut Gustave Roussy between June 1986 and August 2012, clinical data and the pattern of treatment of TT-induced RR were collected. Results were compared with those of prior TT-induced RR publications. Results Sixteen patients with different tumour types were diagnosed with RR observed in the heart, bladder, salivary glands, skin and gastrointestinal tract. The median duration of RR was 1.7 weeks (range: 0.1–13.7) and median time to onset from TT to RR was 16.9 weeks (range: 1–86.9). TT consisted of inhibitors of the mammalian target of rapamycin (mTOR) (n = 5), endothelial growth factor receptor (EGFR) (n = 2), integrin (n = 2), histone deacetylase (HDAC) (n = 2), cell division cycle 7 (CDC7) (n = 1), insulin-like growth factor 1 receptor (IGFR1) (n = 1), cyclin-dependent kinase (CDK) (n = 1), BRAF (n = 1) and a vascular disrupting agent (VDA) (n = 1). Thirteen incriminated TT (81%) were evaluated during early clinical trials and RR led to discontinuation of TT in six patients. All patients had previously received radiotherapy at a median biologically effective dose (BED) of 47 Gy (range: 20–70). The median interval from radiation to TT was 30 months (range: 0.3–363). Immunohistochemical analysis of skin biopsy specimens did not show any transforming growth factor-beta (TGF-β) activation. TT-induced RR characteristics in our population were comparable to those of the nine other cases previously reported in the literature. Conclusion This is the largest case series ever reported on TT-induced RR. RR could be a potential dose-limiting toxicity in early clinical trials. Research is warranted to further understand the exact pathophysiology of this rare but clinically relevant phenomenon." @default.
• W2046871776 created "2016-06-24" @default.
• W2046871776 creator A5008235770 @default.
• W2046871776 creator A5013942703 @default.
• W2046871776 creator A5014829112 @default.
• W2046871776 creator A5021624793 @default.
• W2046871776 creator A5027991868 @default.
• W2046871776 creator A5045670207 @default.
• W2046871776 creator A5056132643 @default.
• W2046871776 creator A5076536874 @default.
• W2046871776 creator A5083142899 @default.
• W2046871776 creator A5086593040 @default.
• W2046871776 creator A5090082356 @default.
• W2046871776 date "2013-05-01" @default.
• W2046871776 modified "2023-10-02" @default.
• W2046871776 title "Targeted therapy-induced radiation recall" @default.
• W2046871776 cites W1966997846 @default.
• W2046871776 cites W1975493627 @default.
• W2046871776 cites W1978058095 @default.
• W2046871776 cites W1989932167 @default.
• W2046871776 cites W1996256916 @default.
• W2046871776 cites W2009730345 @default.
• W2046871776 cites W2019607817 @default.
• W2046871776 cites W2021642794 @default.
• W2046871776 cites W2024333394 @default.
• W2046871776 cites W2038433660 @default.
• W2046871776 cites W2039030227 @default.
• W2046871776 cites W2041457158 @default.
• W2046871776 cites W2045275008 @default.
• W2046871776 cites W2046882520 @default.
• W2046871776 cites W2064054230 @default.
• W2046871776 cites W2067542784 @default.
• W2046871776 cites W2073418794 @default.
• W2046871776 cites W2077187782 @default.
• W2046871776 cites W2078228579 @default.
• W2046871776 cites W2090622818 @default.
• W2046871776 cites W2102737545 @default.
• W2046871776 cites W2116869509 @default.
• W2046871776 cites W2117483391 @default.
• W2046871776 cites W2127738382 @default.
• W2046871776 cites W2136049133 @default.
• W2046871776 cites W2136672090 @default.
• W2046871776 cites W2143634620 @default.
• W2046871776 cites W2155187465 @default.
• W2046871776 cites W2164110803 @default.
• W2046871776 cites W2164956805 @default.
• W2046871776 cites W2546791203 @default.
• W2046871776 doi "https://doi.org/10.1016/j.ejca.2012.12.009" @default.
• W2046871776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23312391" @default.
• W2046871776 hasPublicationYear "2013" @default.
• W2046871776 type Work @default.
• W2046871776 sameAs 2046871776 @default.
• W2046871776 citedByCount "53" @default.
• W2046871776 countsByYear W20468717762013 @default.
• W2046871776 countsByYear W20468717762014 @default.
• W2046871776 countsByYear W20468717762015 @default.
• W2046871776 countsByYear W20468717762016 @default.
• W2046871776 countsByYear W20468717762017 @default.
• W2046871776 countsByYear W20468717762018 @default.
• W2046871776 countsByYear W20468717762019 @default.
• W2046871776 countsByYear W20468717762020 @default.
• W2046871776 countsByYear W20468717762021 @default.
• W2046871776 countsByYear W20468717762022 @default.
• W2046871776 countsByYear W20468717762023 @default.
• W2046871776 crossrefType "journal-article" @default.
• W2046871776 hasAuthorship W2046871776A5008235770 @default.
• W2046871776 hasAuthorship W2046871776A5013942703 @default.
• W2046871776 hasAuthorship W2046871776A5014829112 @default.
• W2046871776 hasAuthorship W2046871776A5021624793 @default.
• W2046871776 hasAuthorship W2046871776A5027991868 @default.
• W2046871776 hasAuthorship W2046871776A5045670207 @default.
• W2046871776 hasAuthorship W2046871776A5056132643 @default.
• W2046871776 hasAuthorship W2046871776A5076536874 @default.
• W2046871776 hasAuthorship W2046871776A5083142899 @default.
• W2046871776 hasAuthorship W2046871776A5086593040 @default.
• W2046871776 hasAuthorship W2046871776A5090082356 @default.
• W2046871776 hasConcept C126322002 @default.
• W2046871776 hasConcept C143998085 @default.
• W2046871776 hasConcept C2778715236 @default.
• W2046871776 hasConcept C509974204 @default.
• W2046871776 hasConcept C71924100 @default.
• W2046871776 hasConcept C90924648 @default.
• W2046871776 hasConceptScore W2046871776C126322002 @default.
• W2046871776 hasConceptScore W2046871776C143998085 @default.
• W2046871776 hasConceptScore W2046871776C2778715236 @default.
• W2046871776 hasConceptScore W2046871776C509974204 @default.
• W2046871776 hasConceptScore W2046871776C71924100 @default.
• W2046871776 hasConceptScore W2046871776C90924648 @default.
• W2046871776 hasIssue "7" @default.
• W2046871776 hasLocation W20468717761 @default.
• W2046871776 hasLocation W20468717762 @default.
• W2046871776 hasOpenAccess W2046871776 @default.
• W2046871776 hasPrimaryLocation W20468717761 @default.
• W2046871776 hasRelatedWork W1968618193 @default.
• W2046871776 hasRelatedWork W2111719509 @default.
• W2046871776 hasRelatedWork W2155262910 @default.
• W2046871776 hasRelatedWork W2160667835 @default.
• W2046871776 hasRelatedWork W2384708512 @default.

• next