FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046872472> ?p ?o ?g. }

• W2046872472 endingPage "336" @default.
• W2046872472 startingPage "325" @default.
• W2046872472 abstract "The Wnt pathway is a key regulator of embryonic development and stem cells, and its aberrant activation is associated with human malignancies, most notably hepatocellular carcinoma (HCC). Epigenetic deregulation of the genes encoding the secreted frizzled-related proteins (sFRPs), the Wnt signalling antagonists, has been linked with aberrant hyperactivation of the Wnt signalling in HCC cells; however, the precise underlying mechanism remains elusive. We investigated the methylation profiles of Wnt antagonists in liver samples of different stages of HCC development and liver cancer cell lines and studied the functional impact of aberrant epigenetic silencing of sFRPs on the canonical Wnt pathway and cell viability. We found that the sFRP1 gene encoding the subunit is a frequent target of aberrant DNA hypermethylation and silencing in HCC tumours, whereas other extracellular Wnt antagonists, WIF1 and Dkk3, exhibited no methylation in tumour cells, consistent with the notion that aberrant methylation events in cancer cells are non-randomly distributed among the genes and that there is a strong preference for hypermethylation of specific genes in HCC. In addition, by comparing sFRP1 methylation status in HCC tumours with normal, cirrhotic and chronic hepatitis liver tissues, we identified sFRP1 gene as a potential early marker of HCC. The restoration of sFRP1 expression in cancer cells by ectopic expression inhibited Wnt activity accompanied with destabilization of β-catenin and downregulation of c-Myc and cyclin D1, the known downstream targets of Wnt pathway. Importantly, restoring sFRP1 levels in cancer cells inhibited cell growth and induced apoptotic cell death. This study supports the critical role for sFRP1 silencing in hepatocellular carcinoma and reinforces the importance of the Wnt antagonists in preventing oncogenic stabilization of β-catenin and chronic activation of the canonical Wnt pathway, suggesting that sFRP1 may be an attractive target for early cancer detection and therapeutic intervention." @default.
• W2046872472 created "2016-06-24" @default.
• W2046872472 creator A5006697510 @default.
• W2046872472 creator A5017633142 @default.
• W2046872472 creator A5033814981 @default.
• W2046872472 creator A5042575799 @default.
• W2046872472 creator A5059231630 @default.
• W2046872472 creator A5070367652 @default.
• W2046872472 creator A5083815533 @default.
• W2046872472 date "2012-02-15" @default.
• W2046872472 modified "2023-10-17" @default.
• W2046872472 title "Epigenetic silencing of sFRP1 activates the canonical Wnt pathway and contributes to increased cell growth and proliferation in hepatocellular carcinoma" @default.
• W2046872472 cites W1975660840 @default.
• W2046872472 cites W1975920726 @default.
• W2046872472 cites W1985146880 @default.
• W2046872472 cites W1990563353 @default.
• W2046872472 cites W2016849135 @default.
• W2046872472 cites W2029868343 @default.
• W2046872472 cites W2038131544 @default.
• W2046872472 cites W2050414776 @default.
• W2046872472 cites W2053278429 @default.
• W2046872472 cites W2054964848 @default.
• W2046872472 cites W2057872902 @default.
• W2046872472 cites W2059857664 @default.
• W2046872472 cites W2064945386 @default.
• W2046872472 cites W2067973442 @default.
• W2046872472 cites W2076334656 @default.
• W2046872472 cites W2079038017 @default.
• W2046872472 cites W2081528617 @default.
• W2046872472 cites W2081985759 @default.
• W2046872472 cites W2082676215 @default.
• W2046872472 cites W2093015940 @default.
• W2046872472 cites W2099292393 @default.
• W2046872472 cites W2102999788 @default.
• W2046872472 cites W2110486307 @default.
• W2046872472 cites W2122669251 @default.
• W2046872472 cites W2137146162 @default.
• W2046872472 cites W2141410747 @default.
• W2046872472 cites W2146167376 @default.
• W2046872472 cites W2155790711 @default.
• W2046872472 cites W2162447344 @default.
• W2046872472 cites W2163638510 @default.
• W2046872472 cites W2239090104 @default.
• W2046872472 cites W83864767 @default.
• W2046872472 doi "https://doi.org/10.1007/s13277-012-0331-5" @default.
• W2046872472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22351518" @default.
• W2046872472 hasPublicationYear "2012" @default.
• W2046872472 type Work @default.
• W2046872472 sameAs 2046872472 @default.
• W2046872472 citedByCount "44" @default.
• W2046872472 countsByYear W20468724722012 @default.
• W2046872472 countsByYear W20468724722013 @default.
• W2046872472 countsByYear W20468724722014 @default.
• W2046872472 countsByYear W20468724722015 @default.
• W2046872472 countsByYear W20468724722016 @default.
• W2046872472 countsByYear W20468724722017 @default.
• W2046872472 countsByYear W20468724722018 @default.
• W2046872472 countsByYear W20468724722019 @default.
• W2046872472 countsByYear W20468724722020 @default.
• W2046872472 countsByYear W20468724722022 @default.
• W2046872472 countsByYear W20468724722023 @default.
• W2046872472 crossrefType "journal-article" @default.
• W2046872472 hasAuthorship W2046872472A5006697510 @default.
• W2046872472 hasAuthorship W2046872472A5017633142 @default.
• W2046872472 hasAuthorship W2046872472A5033814981 @default.
• W2046872472 hasAuthorship W2046872472A5042575799 @default.
• W2046872472 hasAuthorship W2046872472A5059231630 @default.
• W2046872472 hasAuthorship W2046872472A5070367652 @default.
• W2046872472 hasAuthorship W2046872472A5083815533 @default.
• W2046872472 hasConcept C104317684 @default.
• W2046872472 hasConcept C119056186 @default.
• W2046872472 hasConcept C121608353 @default.
• W2046872472 hasConcept C137620995 @default.
• W2046872472 hasConcept C150194340 @default.
• W2046872472 hasConcept C170320316 @default.
• W2046872472 hasConcept C182819311 @default.
• W2046872472 hasConcept C190727270 @default.
• W2046872472 hasConcept C199835354 @default.
• W2046872472 hasConcept C29537977 @default.
• W2046872472 hasConcept C41091548 @default.
• W2046872472 hasConcept C502942594 @default.
• W2046872472 hasConcept C54355233 @default.
• W2046872472 hasConcept C62112901 @default.
• W2046872472 hasConcept C62478195 @default.
• W2046872472 hasConcept C81885089 @default.
• W2046872472 hasConcept C86803240 @default.
• W2046872472 hasConcept C95444343 @default.
• W2046872472 hasConcept C97037327 @default.
• W2046872472 hasConceptScore W2046872472C104317684 @default.
• W2046872472 hasConceptScore W2046872472C119056186 @default.
• W2046872472 hasConceptScore W2046872472C121608353 @default.
• W2046872472 hasConceptScore W2046872472C137620995 @default.
• W2046872472 hasConceptScore W2046872472C150194340 @default.
• W2046872472 hasConceptScore W2046872472C170320316 @default.
• W2046872472 hasConceptScore W2046872472C182819311 @default.
• W2046872472 hasConceptScore W2046872472C190727270 @default.
• W2046872472 hasConceptScore W2046872472C199835354 @default.
• W2046872472 hasConceptScore W2046872472C29537977 @default.

• next