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- W2046875318 abstract "Substantial advances in the past three decades, including risk-factor modification, use of anticoagulants and antiplatelet agents, β blockers, angiotensin-converting-enzyme inhibitors, and effective percutaneous and surgical revascularisation, have reduced the mortality and morbidity of ischaemic heart disease and resulting left ventricular dysfunction. However, heart disease remains the leading cause of death in the west. Furthermore, the progressive nature of ischaemic heart disease, late failures of venous bypass grafts, and restenosis after percutaneous intervention have resulted in an increasing number of patients who are no longer candidates for standard percutaneous or surgical revascularisation yet remain symptomatic on maximum medical therapy. Therapeutic angiogenesis or myogenesis may have a role in these patients who have exhausted all available treatment options, the former aimed at restoring blood flow to ischaemic myocardium and the latter at repopulating contractile elements of the myocardium. 1 Laham RJ Simons M Sellke F Gene transfer for angiogenesis in coronary artery disease. Annu Rev Med. 2001; 52: 485-502 Crossref PubMed Scopus (41) Google Scholar Autologous bone-marrow stem-cell transplantation for myocardial regenerationImplantation of bone-marrow stem cells in the heart might be a new method to restore tissue viability after myocardial infarction. We injected up to 1.5×106 autologous AC133+ bone-marrow cells into the infarct border zone in six patients who had had a myocardial infarction and undergone coronary artery bypass grafting. 3–9 months after surgery, all patients were alive and well, global left-ventricular function was enhanced in four patients, and infarct tissue perfusion had improved strikingly in five patients. Full-Text PDF Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantationResults of experimental studies have shown that intramyocardial implantation of bone marrow cells induces neovascularisation and improves heart function after myocardial infarction. Our aim was to test this notion in people. We implanted autologous mononuclear bone marrow cells into the ischaemic myocardium of eight patients with severe ischaemic heart disease as guided by electromechanical mapping with a percutaneous catheter procedure. After 3 months of follow-up, there was improvement in symptoms, myocardial perfusion, and function at the ischaemic region on MRI. Full-Text PDF" @default.
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- W2046875318 date "2003-01-01" @default.
- W2046875318 modified "2023-10-15" @default.
- W2046875318 title "Bone marrow transplantation for the heart: fact or fiction?" @default.
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- W2046875318 doi "https://doi.org/10.1016/s0140-6736(03)12186-1" @default.
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