FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046875410> ?p ?o ?g. }

• W2046875410 endingPage "424" @default.
• W2046875410 startingPage "418" @default.
• W2046875410 abstract "Background and Objective: A dramatic difference in the frequencies of the Lys/Arg single nucleotide polymorphism in the lactoferrin genotype between a small population of patients with localized juvenile periodontitis and healthy subjects has been reported. As the single nucleotide polymorphism could be associated with ethnicity, the present study aimed to investigate the association between polymorphisms of the lactoferrin gene and periodontitis. Material and Methods: Sixty-five patients with aggressive periodontitis, 278 with chronic periodontitis and 88 healthy controls were genotyped for the Lys/Arg polymorphism of the lactoferrin gene at position 29 [reference sequence (rs) 1126478] in the N-terminal alpha-helical region. Results: The frequencies of the GG genotype and the G allele were highest in the aggressive periodontitis group, followed by the chronic periodontitis group and then the healthy controls. The frequency of the G allele was significantly higher in aggressive periodontitis and chronic periodontitis groups than in healthy controls (p = 0.0037 and 0.0212). Although the difference of the GG genotype distribution between subjects with chronic periodontitis and healthy controls did not reach significance, the distribution of genotypes between aggressive periodontitis and healthy controls was significantly different. The association of the gene polymorphism and aggressive periodontitis still existed, even after adjusting for age, gender and smoking status by logistic regression analysis (GG/AG+AA: odds ratio = 2.16, 95% confidence interval = 1.09–4.35, p = 0.0287). After the study, subjects were further stratified by their smoking status; the GG genotype was still significantly associated with the risk of aggressive periodontitis in the nonsmoking group (odds ratio = 2.69, p = 0.018). However, there were no statistical differences between chronic periodontitis vs. healthy controls and aggressive periodontitis vs. healthy controls in the smoking group. Conclusion: The present study revealed that the A/G polymorphism in the lactoferrin gene might be associated with aggressive periodontitis. The A allele might reduce the risk of development of aggressive periodontitis in a Taiwanese population. Our results also support the hypothesis that lactoferrin genetic polymorphisms could play a role in the risk for periodontitis separate from the smoking factor. The functionality of this gene’s polymorphisms has to be further elucidated." @default.
• W2046875410 created "2016-06-24" @default.
• W2046875410 creator A5005652853 @default.
• W2046875410 creator A5008994470 @default.
• W2046875410 creator A5014071069 @default.
• W2046875410 creator A5015650046 @default.
• W2046875410 creator A5058319449 @default.
• W2046875410 creator A5091443977 @default.
• W2046875410 date "2009-06-01" @default.
• W2046875410 modified "2023-10-12" @default.
• W2046875410 title "Association between lactoferrin gene polymorphisms and aggressive periodontitis among Taiwanese patients" @default.
• W2046875410 cites W1923571095 @default.
• W2046875410 cites W1954443227 @default.
• W2046875410 cites W1967481626 @default.
• W2046875410 cites W1978943755 @default.
• W2046875410 cites W1979278926 @default.
• W2046875410 cites W1985146167 @default.
• W2046875410 cites W1994960026 @default.
• W2046875410 cites W1997357193 @default.
• W2046875410 cites W2001492139 @default.
• W2046875410 cites W2010710109 @default.
• W2046875410 cites W2017817710 @default.
• W2046875410 cites W2020785125 @default.
• W2046875410 cites W2030227308 @default.
• W2046875410 cites W2037315239 @default.
• W2046875410 cites W2056056637 @default.
• W2046875410 cites W2057121756 @default.
• W2046875410 cites W2058712377 @default.
• W2046875410 cites W2063000280 @default.
• W2046875410 cites W2069423686 @default.
• W2046875410 cites W2071086823 @default.
• W2046875410 cites W2078825909 @default.
• W2046875410 cites W2086033902 @default.
• W2046875410 cites W2103038929 @default.
• W2046875410 cites W2111971471 @default.
• W2046875410 cites W2116850635 @default.
• W2046875410 cites W2122385641 @default.
• W2046875410 cites W2141948326 @default.
• W2046875410 cites W2150094471 @default.
• W2046875410 cites W2155008443 @default.
• W2046875410 cites W2165298247 @default.
• W2046875410 cites W2168666458 @default.
• W2046875410 cites W2176563609 @default.
• W2046875410 cites W2177594905 @default.
• W2046875410 doi "https://doi.org/10.1111/j.1600-0765.2008.01120.x" @default.
• W2046875410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18973542" @default.
• W2046875410 hasPublicationYear "2009" @default.
• W2046875410 type Work @default.
• W2046875410 sameAs 2046875410 @default.
• W2046875410 citedByCount "34" @default.
• W2046875410 countsByYear W20468754102012 @default.
• W2046875410 countsByYear W20468754102013 @default.
• W2046875410 countsByYear W20468754102014 @default.
• W2046875410 countsByYear W20468754102015 @default.
• W2046875410 countsByYear W20468754102016 @default.
• W2046875410 countsByYear W20468754102017 @default.
• W2046875410 countsByYear W20468754102018 @default.
• W2046875410 countsByYear W20468754102020 @default.
• W2046875410 countsByYear W20468754102022 @default.
• W2046875410 countsByYear W20468754102023 @default.
• W2046875410 crossrefType "journal-article" @default.
• W2046875410 hasAuthorship W2046875410A5005652853 @default.
• W2046875410 hasAuthorship W2046875410A5008994470 @default.
• W2046875410 hasAuthorship W2046875410A5014071069 @default.
• W2046875410 hasAuthorship W2046875410A5015650046 @default.
• W2046875410 hasAuthorship W2046875410A5058319449 @default.
• W2046875410 hasAuthorship W2046875410A5091443977 @default.
• W2046875410 hasConcept C104317684 @default.
• W2046875410 hasConcept C126322002 @default.
• W2046875410 hasConcept C135763542 @default.
• W2046875410 hasConcept C149737253 @default.
• W2046875410 hasConcept C153209595 @default.
• W2046875410 hasConcept C156957248 @default.
• W2046875410 hasConcept C180754005 @default.
• W2046875410 hasConcept C203014093 @default.
• W2046875410 hasConcept C2778883934 @default.
• W2046875410 hasConcept C2779170986 @default.
• W2046875410 hasConcept C2779337755 @default.
• W2046875410 hasConcept C2780385504 @default.
• W2046875410 hasConcept C44249647 @default.
• W2046875410 hasConcept C54355233 @default.
• W2046875410 hasConcept C71924100 @default.
• W2046875410 hasConcept C76252995 @default.
• W2046875410 hasConcept C86803240 @default.
• W2046875410 hasConcept C90924648 @default.
• W2046875410 hasConceptScore W2046875410C104317684 @default.
• W2046875410 hasConceptScore W2046875410C126322002 @default.
• W2046875410 hasConceptScore W2046875410C135763542 @default.
• W2046875410 hasConceptScore W2046875410C149737253 @default.
• W2046875410 hasConceptScore W2046875410C153209595 @default.
• W2046875410 hasConceptScore W2046875410C156957248 @default.
• W2046875410 hasConceptScore W2046875410C180754005 @default.
• W2046875410 hasConceptScore W2046875410C203014093 @default.
• W2046875410 hasConceptScore W2046875410C2778883934 @default.
• W2046875410 hasConceptScore W2046875410C2779170986 @default.
• W2046875410 hasConceptScore W2046875410C2779337755 @default.
• W2046875410 hasConceptScore W2046875410C2780385504 @default.
• W2046875410 hasConceptScore W2046875410C44249647 @default.

• next