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- W2046887654 abstract "To compare the cost-effectiveness of Follitropin Alpha (Gonal-F®), which is a recombinant FSH, with a urinary highly purified hp-FSH (Menopur®) used in assisted reproduction in Greece. A decision tree in combination with a Markov model was constructed to assess the clinical and economical impact of comparators for three consecutives cycles. Transition probabilities for all stages of a treatment cycle (i.e, cancelled ovum retrieval, successful recovery of oocytes etc) were derived from literature and validated by clinical experts. Cost components such as “initial treatment cost”, cost of “oocytes”, “oocyte pick-up”, “fertilization”, “transfer”, “cryo preservation” and “frozen- thawed embryo transfer (FET)” were derived from the electronic databases of selected private and public clinics. The average number of units used per IVF and the rate of adverse events were based on the literature. Drug prices and reimbursement tariffs, were obtained from the “Government Gazette” and valued at 2011 prices. A probabilistic sensitivity analysis was performed to deal with uncertainty and to construct variability measures. There was a statistically significant difference in favor of the r-FSH arm compared to hp-HMG, which is associated with 52 more life births (95%CI: 26-78, p-value<0.001) per 1,000 patients. The cost per life birth was estimated at €16,906 (95%CI: €16,347 – €17,516) and €17,286 (95%CI: €16,740 – €17,845) in the r-FSH and hp-HMG arms, respectively. The cost per IVF was estimated at €4,365 (95%CI: €4,205 – €4,506) in the r-FSH and €3,815 (95%CI: €3,661 – €3,953) in hp-HMG arm, indicating a difference at €550 (95%CI: €365 – €730, p-value<0.001). The incremental cost per life birth (ICER) for r-FSH versus hp-HMG was estimated at €14,540 (95%CI: €10,509 – €21,868), while the incremental cost per life year was estimated at €4,153 (95%CI: €2,038 – €6,233). r-FSH may represent a cost-effective choice compared with a urinary hp-FSH (Menopur®) used for ovarian stimulation in the Greek setting." @default.
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- W2046887654 date "2011-11-01" @default.
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- W2046887654 title "PDB42 Economic Evaluation of Recombinant Human FSH in Comparison with Urinary HMG in Assisted Reproduction in the Greek Setting" @default.
- W2046887654 doi "https://doi.org/10.1016/j.jval.2011.08.1345" @default.
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