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• W2046898715 abstract "Because naïve T cells are unable to import cystine due to the absence of cystine transporters, it has been suggested that T cell activation is dependent on cysteine generated by antigen presenting cells. The aim of this study was to determine at which phases during T cell activation exogenous cystine/cysteine is required and how T cells meet this requirement. We found that early activation of T cells is independent of exogenous cystine/cysteine, whereas T cell proliferation is strictly dependent of uptake of exogenous cystine/cysteine. Naïve T cells express no or very low levels of both cystine and cysteine transporters. However, we found that these transporters become strongly up-regulated during T cell activation and provide activated T cells with the required amount of cystine/cysteine needed for T cell proliferation. Thus, T cells are equipped with mechanisms that allow T cell activation and proliferation independently of cysteine generated by antigen presenting cells." @default.
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• W2046898715 date "2012-02-14" @default.
• W2046898715 modified "2023-10-06" @default.
• W2046898715 title "Activated human CD4+ T cells express transporters for both cysteine and cystine" @default.
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• W2046898715 doi "https://doi.org/10.1038/srep00266" @default.
• W2046898715 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3278673" @default.
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