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- W2046918108 abstract "We have investigated the correlation between urinary isatin concentration and MAO-B inhibitory activity. A sensitive enzyme-linked immunosorbent assay (ELISA) for the measurement of isatin in urine was developed. There was a strong correlation between isatin concentrations determined by this method and the established GC/MS technique. In two sets of urine samples from healthy individuals (N = 63 and N = 21), we have shown that there is no significant correlation between isatin concentration and MAO-B inhibitory activity (r = − 0.1013 and − 0.1597, respectively). Based upon IC50 measures, the concentration of isatin in normal urine (N = 10) was 3– 5 times less than that which could account for the detected MAO-B inhibitory activity. Furthermore, Lineweaver-Burk plots from urine samples (N = 12) compared with isatin showed that the inhibition by isatin was competitive whereas urine samples could elicit either mixed or non-competitive inhibition. We conclude that the MAO-B inhibitory activity in urine cannot be attributed to isatin alone and another inhibitor(s) appears to be present." @default.
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- W2046918108 date "1996-01-01" @default.
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- W2046918108 title "The relationship between isatin and monoamine oxidase-B inhibitory activity in urine" @default.
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- W2046918108 doi "https://doi.org/10.1002/(sici)1099-1700(199601)12:1<35::aid-smi676>3.0.co;2-2" @default.
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